Molecular epidemiology, pathogenesis, and genetics of the dimorphic fungus

Retallack, Diane M.; Woods, Jon P.

doi:10.1016/s1286-4579(99)80084-7

Cited by 46 publications

(28 citation statements)

References 68 publications

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“…2 Humans and other mammals are infected through inhaled fungal fragments or spores. Infections are often undiagnosed in healthy hosts, but exposure to large doses of fungi leads to lethal, disseminated infections.…”

Section: Introductionmentioning

confidence: 99%

The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse

Mayfield

Rine

2007

Genes Immun

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The pathogenic fungus Histoplasma capsulatum causes disease ranging from mild to fatal in healthy and immunocompromised humans. Infection rates reach 80% in endemic areas, including the Midwestern United States. We used inbred mice to identify a 300-fold difference in fungal burden. A/J mice showed lower fungal burden and morbidity than C57BL/6J mice, a reversal of the trend observed for many bacterial pathogens. We mapped the differences in fungal burden to discrete locations on chromosomes 1, 6, 15 and 17 with high significance. Substitution of a single resistant chromosome 17 onto the susceptible background was sufficient to lower fungal burden. These loci will allow dissection of the fungal-specific immune program.

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Section: Introductionmentioning

confidence: 99%

The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse

Mayfield

Rine

2007

Genes Immun

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“…capsulatum (Hc) is the most prevalent cause of fungal respiratory disease, infecting approximately 500,000 individuals in the US each year (1)(2)(3). Infection usually results in a mild, often asymptomatic respiratory illness but may progress to life-threatening systemic disease, particularly in individuals with AIDS (4,5).…”

Section: Introductionmentioning

confidence: 99%

Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum

Nosanchuk¹,

Steenbergen²,

Li³

et al. 2003

J. Clin. Invest.

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A protective role for antibodies has not previously been described for host defense against the pathogenic fungus Histoplasma capsulatum (Hc). Mouse mAb's were generated from mice immunized with Hc yeast that binds the cell surface of Hc. Administration of mAb's before Hc infection reduced fungal burden, decreased pulmonary inflammation, and prolonged survival in a murine infection model. Protection mediated by mAb's was associated with enhanced levels of IL-4, IL-6, and IFN-γ in the lungs of infected mice. The mAb's increased phagocytosis of yeast by J774.16 cells through a CR3-dependent process. Ingestion of mAb-opsonized Hc by J774.16 macrophage-like cells was associated with yeast cell growth inhibition and killing. The mAb's bound to a 17-kDa antigen expressed on the surface of Hc. The antigen was identified as a histone H2B-like protein. This study establishes that mAb's to a cell surface protein of Hc alter the intracellular fate of the fungus and mediate protection in a murine model of lethal histoplasmosis, and it suggests a new candidate antigen for vaccine development.

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“…capsulatum is a pathogenic dimorphic fungus with a worldwide distribution. H. capsulatum is the leading cause of fungal respiratory disease, infecting approximately 500,000 individuals in the United States annually (6,10,43). Infection is frequently asymptomatic or results in a mild pulmonary illness, but it may progress to life-threatening systemic disease, particularly in individuals with AIDS (24,58).…”

mentioning

confidence: 99%

A Monoclonal Antibody toHistoplasma capsulatumAlters the Intracellular Fate of the Fungus in Murine Macrophages

Shi¹,

Albuquerque²,

Lázár‐Molnár

et al. 2008

Eukaryot Cell

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Molecular epidemiology, pathogenesis, and genetics of the dimorphic fungus

Cited by 46 publications

References 68 publications

The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse

The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse

Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum

A Monoclonal Antibody toHistoplasma capsulatumAlters the Intracellular Fate of the Fungus in Murine Macrophages

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