Molecular Epidemiology of Recurrent Cutaneous Methicillin-Resistant Staphylococcus aureus Infections in Children

Abstract

We assessed the relatedness by repetitive-sequence polymerase chain reaction of isolates obtained from children with recurrent methicillin-resistant Staphylococcus aureus cutaneous infections over 6 years. Ninety percent of the cases could be attributed to recurrence of the same strain type, suggesting that optimized decolonization methods in children might effectively prevent recurrent infection.

Molecular Epidemiology of Methicillin-resistant Staphylococcus aureus Isolated in Serial Cultures From the Respiratory Tract of Children with Cystic Fibrosis

“…We demonstrated in a previous analysis (18) that the majority of recurrent MRSA skin infections in healthy children are caused by identical strain types. In the present study, we analyzed isolates of MRSA recovered from serial respiratory cultures from CF patients, using repetitive-sequence polymerase chain reaction (repPCR) to interrogate strain relatedness.…”

Osteoarticular Infections Following Open or Penetrating Trauma in Children in the Post-Community-Acquired Methicillin-resistant Staphylococcus aureus Era: The Impact of Enterobacter cloacae

“…While the prevalence of invasive CA-MRSA is declining in some centers, 5 it still contributes substantially to hematogenous OAI in children. Furthermore, many regions have experienced an increase in the proportion of CA-MRSA isolates that are resistant to clindamycin, 6 limiting options for treatment.…”

Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis

“…In a recent study from St Louis, the prevalence of clindamycin resistance among MRSA causing soft tissue infections was 13%. 4 Deep cultures obtained from bone, subperiosteal abscesses, or adjacent purulent collections in children with osteomyelitis can provide both microbiologic diagnosis and therapeutic benefit. Cultures obtained from bone yield a pathogen in ≤67% of children with osteomyelitis.…”