Molecular epidemiology of rabies in northern Colombia 1994–2003. Evidence for human and fox rabies associated with dogs

Páez, Andrés; Saad, Cecilia; Núñez, Constanza; Bóshell, Jorge

doi:10.1017/s0950268805003699

Cited by 32 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…La población colombiana se ha visto afectada históricamente por brotes urbanos y de origen silvestre (6)(7)(8)(9)(10)(11)(12). El brote urbano más reciente ocurrió en los años 2006-2008 en el Distrito Turístico de Santa Marta, departamento del Magdalena, el cual cobró la vida de cuatro humanos y de decenas de perros (10).…”

unclassified

Evaluación de la seroconversión como respuesta a la vacunación antirrábica en perros en el departamento del Valle del Cauca, Colombia, 2009

Páez

Hernández²,

Escobar

et al. 2011

biomedica

View full text Add to dashboard Cite

Resultados. El 9,1 % de los perros de la muestra fueron seronegativos y el 25,1 % no evidenciaron respuesta inmunitaria humoral adecuada a la vacunación. La concentración de anticuerpos disminuyó gradualmente desde la aplicación de la vacuna, y estuvo asociada a edad y calidad de las vacunas, aunque no estuvo asociada a sexo ni a raza. Conclusiones. Con el fin de aumentar los porcentajes de perros seropositivos y con respuesta inmunitaria humoral adecuada, se hacen las siguientes recomendaciones: 1) utilizar vacunas antirrábicas viables; 2) aplicar dos dosis de vacuna durante los primeros seis meses de vida de los cachorros; 3) aplicar refuerzos de vacuna, por lo menos, una vez al año; 4) que las autoridades vigilen las actividades y los procesos programáticos relacionados con la vacunación antirrábica por particulares.Palabras clave: vacunas antirrábicas, virus de la rabia, Lyssavirus, zoonosis, vigilancia epidemiológica, inmunidad, Colombia. Evaluation of the seroconversion as a response to rabies vaccination in dogs, Valle del Cauca, Colombia, 2009Introduction. The province of Valle del Cauca has been free of dog rabies for more than 20 years. However, sylvatic rabies foci remain which are threats to the health of the populace and its pets. Rabies vaccination campaigns are carried out annually in all 42 counties of the province. Objectives. The impact of dog vaccination was evaluated on the basis of humoral immunoresponse, population parameters and correlation with variables inherent to the vaccination process and logistics. Materials and methods. Sera and associated data were obtained from each of the 42 counties for a total sample of 569 rabies-vaccinated dogs. Rabies neutralizing antibodies were measured by quantitative ELISA. The data were analyzed with the statistical programs in Epi-Info 6.0.Results. Nearly 10% of dogs were seronegative (9.1%) and an additional 25.1% did not elicit an adequate humoral immune response to vaccination. Concentration of rabies neutralizing antibodies diminished gradually with the time after vaccination and was correlated with dog age and vaccine quality. No associations were noted between dog gender or breed. Conclusions. These data permit the following recommendations: (1) only viable, non expired rabies vaccines must be used to immunize animals, (2) two doses of rabies vaccine must be applied during the first six months of dog life, (3) booster immunizations must be administered every year, (4) practices

show abstract

unclassified

Evaluación de la seroconversión como respuesta a la vacunación antirrábica en perros en el departamento del Valle del Cauca, Colombia, 2009

Páez

Hernández²,

Escobar

et al. 2011

biomedica

View full text Add to dashboard Cite

show abstract

“…Nucleotide sequence analysis permits the most precise definition of virus type and helps in understanding the transmission of rabies virus from the reservoir host to other hosts, including humans and domestic animals. To date, molecular epidemiological studies of rabies viruses have been performed by sequencing different regions of RV genomes (4,5,8,13,14,15,24,26,27,28,29,30,32,33,36,42). This report describes the genetic characterization of Indian RV isolates through nucleotide sequencing of the G-CD region and of the noncoding G-L intergenic region (Psi) and the L region (Psi-L region).…”

mentioning

confidence: 99%

Molecular Epidemiology of Rabies Virus Isolates in India

et al. 2006

View full text Add to dashboard Cite

In India, rabies is enzootic and is a serious public health and economic problem. India has a large population of stray dogs which, together with a lack of effective control strategies, might have led to the persistence of rabies virus (RV) in the canine population. Our objective was to study the molecular epidemiology of RV isolates in India based on nucleotide sequence analysis of 29 RV isolates originating from different species of animals in four states. Here we have analyzed two sets of sequence data based upon a 132-nucleotide region of the cytoplasmic domain (CD) of the G gene (G-CD) and a 549-nucleotide region (Psi-L) that combines the noncoding G-L intergenic region (Psi) and a fragment of the polymerase gene (L). Phylogenetic analysis revealed that the RV isolates belong to genotype 1 and that they were related geographically but were not related according to host species. Five different genetic clusters distributed among three geographical regions were identified. Comparison of the deduced amino acid sequences of G-CD between RV isolates revealed three amino acid changes (amino acid 462G [aa462G], aa465H, and aa468K) that distinguished the Indian RVs from RV isolates in other parts of the world. Analysis of the data indicated that the dog rabies virus variants are the major circulating viruses in India that transmit the disease to other domestic animals and humans as well.

show abstract

“…RV transmissions among dogs and wild canids has been reported in Africa, Europe, Colombia, Mexico, and Turkey, and infection of wildlife species contributes to the difficulties associated with controlling and eradicating rabies in wildlife [3,16,19,20,25]. Fox RV isolates from northeastern Brazil have been reported to form specific clades that group independently of dog RV isolates despite evidence suggesting that dog and fox rabies are derived from a common ancestor [2,4,22,23].…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic Characterization of Rabies Virus Isolates from Carnivora in Brazil

Kobayashi

Inoue

Sato

et al. 2007

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. The incidence of canine rabies has been widely reported in Brazil, and new rabies virus (RV) variants, genetically similar to canine RV, have recently been isolated from foxes. In order to derive the epidemiological characteristics of Brazilian Carnivora RV, Brazilian RVs isolated from dogs, cats, and foxes were genetically analyzed. Brazilian Carnivora RV isolates were divided into 2 main lineages. The predominant lineage was found in dogs and cats, which included the Argentinean and Bolivian Carnivora RV isolates, and was extensively distributed throughout Brazil and surrounding countries. The other lineage consisted of three sublineages containing Brazilian dog and fox RV isolates, with the dog sublineages located on an internal branch of 2 fox sublineages, suggesting that RV transmission events might have occurred between foxes and dogs in the past. These results suggest that contact between dogs and wildlife has the potential to generate new rabies variants and that it is important to control RV infection cycles in both dogs and wildlife to prevent spread of rabies infection.

show abstract

Molecular epidemiology of rabies in northern Colombia 1994–2003. Evidence for human and fox rabies associated with dogs

Cited by 32 publications

References 21 publications

Evaluación de la seroconversión como respuesta a la vacunación antirrábica en perros en el departamento del Valle del Cauca, Colombia, 2009

Evaluación de la seroconversión como respuesta a la vacunación antirrábica en perros en el departamento del Valle del Cauca, Colombia, 2009

Molecular Epidemiology of Rabies Virus Isolates in India

Phylogenetic Characterization of Rabies Virus Isolates from Carnivora in Brazil

Contact Info

Product

Resources

About