Molecular epidemiology of human Herpesviruses types 1–6 and 8 among Greek blood donors

Rouka, Erasmia; Kyriakou, Despoina

doi:10.1111/tme.12202

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…In turn, immune activation may stimulate subclinical reactivations of CMV. Accordingly, prevalence of CMV DNA in studies of HIV patients (15.8-42.2%) was high [56][57][58][59] when compared to studies of CMV DNA in healthy controls [60][61][62], though we find no studies where patients and controls were assessed in parallel. This could increase the prevalence and severity of inflammatory disorders linked with CMV.…”

Section: And Inflammagingcontrasting

confidence: 57%

HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV

Waters

Brook

Lee

et al. 2018

Clinical Immunology

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Cytomegalovirus (CMV) is a β-herpesvirus. Latent infections are common in all populations. However age-associated increases in levels of CMV-reactive antibody are testament to repeated reactivations and periods of viral replication. CMV has been associated with several diseases of aging, including vasculopathy and neurocognitive impairment. These conditions occur at a younger age in persons with particularly high burdens of CMV - transplant recipients and people living with HIV. Here we define the "clinical footprints" as immunopathologies triggered by CMV that develop over many years. A high burden of CMV also drives accumulation of multifunctional terminally-differentiated αβ T-cells, a novel population of Vδ2 γδ T-cells, and a population of CD56 NK cells lacking a key regulatory molecule. An understanding of these "immunological footprints" of CMV may reveal how they collectively promote the "clinical footprints" of the virus. This is explored here in transplant recipients, HIV patients and healthy aging.

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Section: And Inflammagingcontrasting

confidence: 57%

HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV

Waters

Brook

Lee

et al. 2018

Clinical Immunology

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“…Among 176 Japanese pediatric patients visiting medical facilities for various reasons, HHV-6 DNA was detected in four (2.2%) whole-blood samples (55). The prevalence of HHV-6 DNA detection among blood donors was estimated to be 3.5% in a Greek cohort of 401 subjects and 6.1% in a cohort of 198 subjects from Burkina Faso (56,57). Metagenomic analysis of whole-blood samples of more than 8,000 individuals considered healthy revealed the identification of HHV-6A and HHV-6B in 1.5% and 5% of individuals, respectively (30).…”

Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

2020

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SUMMARY Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with high morbidity and mortality. Among these patients, viral infections are frequently associated with viremia. Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral signatures or genomes can be identified in the blood of these patients. The identification of novel viral species and variants by metagenomic next-generation sequencing has opened up a new field of investigation and new paradigms. Thus, there is a need to thoroughly describe the state of knowledge in this field with a review of all viral infections that should be scrutinized in high-risk populations. Here, we review the eukaryotic DNA and RNA viruses identified in blood, plasma, or serum samples of pediatric and adult SOT/HSCT recipients and the prevalence of their detection, with a particular focus on recently identified viruses and those for which their potential association with disease remains to be investigated, such as members of the Polyomaviridae, Anelloviridae, Flaviviridae, and Astroviridae families. Current knowledge of the clinical significance of these viral infections with associated viremia among transplant recipients is also discussed. To ensure a comprehensive description in these two populations, individuals described as healthy (mostly blood donors) are considered for comparative purposes. The list of viruses that should be on the clinicians’ radar is certainly incomplete and will expand, but the challenge is to identify those of possible clinical significance.

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“…The prevalence of iciHHV-6 appears to vary by country and region (Tanaka-Taya et al, 2004;Leong et al, 2007;Hudnall et al, 2008;Bell et al, 2014). In a previous study we have suggested that the prevalence in Greece is 1 of 401 or 0.25% (Rouka & Kyriakou, 2015). Immunocompetent individuals with iciHHV-6 have high levels of HHV-6 DNA both in cellular and non-cellular samples (Leong et al, 2007).…”

Section: Dear Sirmentioning

confidence: 96%

“…In a previous study we have suggested that the prevalence in Greece is 1 of 401 or 0.25% (Rouka & Kyriakou, 2015). Immunocompetent individuals with iciHHV-6 have high levels of HHV-6 DNA both in cellular and non-cellular samples (Leong et al, 2007).…”

Section: Dear Sirmentioning

confidence: 98%

Diagnosis of Chromosomally Integrated HHV‐6: Comment on the ‘Molecular prevalence of human Herpesviruses types 1‐6 and 8 in Greek blood donors’

Rouka¹,

Kyriakou²

2016

Transfusion Medicine

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Molecular epidemiology of human Herpesviruses types 1–6 and 8 among Greek blood donors

Cited by 6 publications

References 24 publications

HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV

HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

Diagnosis of Chromosomally Integrated HHV‐6: Comment on the ‘Molecular prevalence of human Herpesviruses types 1‐6 and 8 in Greek blood donors’

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