Molecular epidemiology of human cases of tuberculosis by Mycobacterium bovis in Mexico

Milián-Suazo, Feliciano; Pérez-Guerrero, Laura; Arriaga-Díaz, Camila; Escartín-Chávez, Minerva

doi:10.1016/j.prevetmed.2010.06.015

Cited by 20 publications

(22 citation statements)

References 30 publications

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“…The spoligotype pattern of one of the M. bovis isolates was identified as SB0673, which is one of the most frequent spoligotypes in cattle in Mexico. This spoligotype has been identified previously in other cases of human tuberculosis, in Mexico [26], as well as in the United States in patients of Mexican origin [27,28]. The spoligotype from the second isolate was SB0971, which is the fifth most common spoligotype in Mexico, and it has also been identified in humans from previous studies in Mexico, as well as in the United States in patients of Mexican origin.…”

Section: Resultssupporting

confidence: 66%

“…In humans, M. bovis is an opportunistic pathogen that takes advantage of vulnerable populations, such as those with acquired immunodeficiency syndrome (AIDS) [12][13][14], diabetes mellitus, the presence of lymphomas, leukemia, chronic renal insufficiency, immunosuppressant treatments, disorders associated to gastrectomy and jejunoileal surgery, malnutrition, overpopulation, smoking and drug addiction [15][16][17][18][19][20][21]. The presence of M. bovis in human cases is relevant since it is resistant to pyrazinamide, a first-line antibiotic used in the treatment of tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

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Whole Genome Sequencing for Detection of Zoonotic Tuberculosis in Queretaro, Mexico

Perea¹,

Suazo²,

Reyes³

et al. 2017

J Infect Dis Preve Med

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A total of 2,736 samples, sputum, urine, and other fluids, collected from 1,154 tuberculosis suspicious patients in Queretaro, Mexico were included in the study. Acid-fast staining and culture in selective mediums, Stonebrink and Lowenstein-Jensen, were performed in all samples. Genotyping of isolates was performed by spoligotyping and single nucleotide polimorfism (SNP) whole genome sequencing. Mycobacterium bovis spoligotypes and SNP-types obtained were compared to those of cattle found in a database. Twenty-one (1.8%) isolates of Mycobacterium were obtained by culture, all from sputum; two (13%) were identified as M. bovis by spoligotyping, SB0673 and SB0971, which are frequently found in cattle in Mexico. From the isolates´ total, 15 were whole genome sequenced, confirming two as M. bovis. The SNP patterns of the two M. bovis isolates from human were similar to those found in cattle in different parts of Mexico.

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Section: Resultssupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Whole Genome Sequencing for Detection of Zoonotic Tuberculosis in Queretaro, Mexico

Perea¹,

Suazo²,

Reyes³

et al. 2017

J Infect Dis Preve Med

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“…restriction fragment length polymorphism probes IS6110, variable-number tandem-repeat loci) for both species, with small modifications. This has promoted the generation of international databanks of genotypes as well as trace-back and trace-forward investigations in human and animal, including wildlife, populations across countries and continents (12,36,37,38,39,40,41,42,43,44,45,46 …”

Section: Molecular Epidemiology As a One Health Toolmentioning

confidence: 99%

Improving specific disease outcomes through a One Health approach – tuberculosis

Michel¹

2014

Rev. Sci. Tech. OIE

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SummaryEarly discoveries in the field of tuberculosis more than a century ago indicated that the success of disease control in human populations would depend on the success of control measures in animals, and vice versa. Recognising the zoonotic importance of a cattle-derived pathogen was the beginning of the eradication of bovine tuberculosis from most of the cattle population in Europe. It was a costly and resource-intensive process, but a successful one. The resulting near disappearance of zoonotic tuberculosis from the human population exemplifies probably one of the largest One Health successes in medical history. Since that time many advances in tuberculosis diagnosis, vaccinology, molecular epidemiology and immunopathogenetic studies have been made within the disciplinary divides of human and animal health research. More recently, the discovery of similarities in the interactions between the natural hosts and the causative agents of tuberculosis, as well as similarities in the resulting disease consequences, have led to a renewed appraisal of the benefits of collaborative approaches. It is to be hoped that, in the future, the combined body of scientific knowledge will also provide the basis for practical One Health initiatives at community level.

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“…Ésta es una de las enfermedades más importantes en la industria pecuaria al ocasionar graves pérdidas económicas, y representar una barrera para la comercialización del ganado y sus subproductos; además de constituir un riesgo para la salud humana (2) . La incidencia actual de la infección por M. bovis en humanos es subestimada (3) , pero se cree que el número de casos de tuberculosis en humanos asociada a M. bovis es del 3 al 13 % (4) . No obstante, algunos reportes muestran porcentajes mayores; por ejemplo, en un análisis retrospectivo de casos de tuberculosis en una comunidad binacional en San Diego California de 1994 a 2005, se identificó a M. bovis en 45 % de los casos en niños y 6 % de adultos, lo que demuestra que M. bovis puede representar un gran riesgo para la salud pública (5) .…”

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“…Estos se infectaron con la cepa M. bovis BCG Danesa durante 4 h a una multiplicidad de infección (MOI) de 10 bacterias por macrófago y se centrifugaron a 200 xg durante 10 min. El ensayo bactericida de macrófagos se realizó con 1x10 4 células por pocillo en placas Nunc Mini (Nalge Nunc International, Rochester, NY, EE.UU.). Los macrófagos obtenidos de cada animal se colocaron por triplicado, como control negativo se incluyeron tres pocillos con macrófagos no infectados.…”

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Mycobacterium bovis induce una respuesta inmune celular heterogénea en bovinos infectados naturalmente

López¹,

Flores-Villalva

Pabello³

2017

Rev. Mex. Cienc. Pecu.

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la hipótesis de que las limitaciones en el funcionamiento de los macrófagos y los linfocitos T desempeñan un papel muy importante en la diseminación de la enfermedad.Palabras clave: IFN-γ, Macrófagos, Mycobacterium bovis, PPDB, Coctel proteico. Abstract:Macrophages are considered one of the main immune mechanisms of resistance to mycobacterial infections. In addition, experimental and clinical data indicate that IFN-γ is essential for host defence against M. tuberculosis. The aim of this study was to identify macrophage capacity on controlling Mycobacterium bovis infection and lymphocyte IFN-γ production from cattle naturally exposed to M. bovis. Peripheral blood monocyte-derive macrophages from naturally infected cattle were evaluated for their ability to control the intracellular growth of M. bovis BCG. Besides, whole blood cells were stimulated with PPDB and ESAT-6+CFP-10 protein cocktail. Results show a disparity in host susceptibility to Mycobacterium bovis. A M. bovis BCG survival rate of 80 to 150 % in macrophages from naturally infected cattle was observed. While the IFN-γ production towards Purified protein derivative bovine (PPDB) and the protein cocktail was 2.5 and 2.0 optic density index, respectively. Though our data do not support a correlation between the host susceptibility to M. bovis and the production of IFN-γ in naturally infected cattle, the hypothesis that the limitations in the functioning of macrophages and T lymphocytes play a very important role in the spread of the disease cannot be discarded.

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Molecular epidemiology of human cases of tuberculosis by Mycobacterium bovis in Mexico

Cited by 20 publications

References 30 publications

Whole Genome Sequencing for Detection of Zoonotic Tuberculosis in Queretaro, Mexico

Whole Genome Sequencing for Detection of Zoonotic Tuberculosis in Queretaro, Mexico

Improving specific disease outcomes through a One Health approach – tuberculosis

Mycobacterium bovis induce una respuesta inmune celular heterogénea en bovinos infectados naturalmente

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