Molecular Epidemiology of Human Astrovirus Infection in Hospitalized Children with Acute Gastroenteritis

Chung, Jin-Gyun; Huh, Kyung Rim; Kim, Sang Woo; Shin, Bo Mun; Han, Tae Hee; Lee, Jae-In; Song, Mi Ok

doi:10.5223/kjpgn.2006.9.2.139

Cited by 9 publications

(13 citation statements)

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“…This is consistent with studies in Nigeria and Spain [ 13 , 21 ]. This, however, did not agree with the reports of Chung et al [ 12 ] and Koh et al [ 22 ], who had rotavirus-norovirus mixed infection as the most prevalent.…”

Section: Resultscontrasting

confidence: 90%

“…It is higher than 6.7% in Nigeria [ 7 ], 3.0% in South Africa [ 15 ], and 7.8% in Botswana [ 11 ]. The 3.6% of norovirus in this study is lower than 37.3% in Nigeria [ 16 ], 16.4% in Ghana [ 17 ], 39% in Brazil [ 18 ], 11.6% in Korea [ 12 ], and 15% in Ghana [ 19 ]. The differences among studies reporting viral infections in different countries might be explained by the different age group, seasonal variations, and viral detection methods used.…”

Section: Resultsmentioning

confidence: 69%

“…The 28.3% of rotavirus in this study is lower than 55.9% in Ilorin, Nigeria [ 5 ], 35% in Jos, Nigeria [ 6 ], 33.3% in two districts in Nigeria [ 7 ], and 39% in Ghana [ 8 ]. It is higher than 27% in Zaria, Nigeria [ 9 ], 28.1% in Edo State, Nigeria [ 10 ], 9.2% in Botswana [ 11 ], and 16.9% in Korea [ 12 ]. The 19.3% of adenovirus in this study is lower than 22.3% in northwestern Nigeria [ 13 ] and 23.0% in Tanzania [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

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Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria

Imade

Eghafona

2015

International Journal of Microbiology

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Enteric viruses have been shown to be responsible for diarrhea among children during their early childhood. This study was carried out to determine the prevalence of rotavirus, adenovirus, and norovirus infection in young children with diarrhea in two primary health centers in Edo State, Nigeria. A total of 223 stool specimens were collected from children aged 0–36 months with clinical signs of diarrhea and 59 apparently healthy age-matched children as control. These specimens were investigated for three viral agents using immunochromatographic technique (ICT). The overall results showed that at least one viral agent was detected in 95/223 (42.6%) of the children with diarrhea while the control had none. The prevalence of rotavirus was 28.3%, adenovirus 19.3%, and norovirus 3.6%. There was a significant association between age group and infection (P < 0.0001). Seasonal pattern of enteric viruses was not statistically significant (P = 0.17). The overall coinfection rate was 7.6% and rotavirus-adenovirus coinfection had the highest with 5.4%. Rotavirus was the most prevalent viral agent. Coinfections are not uncommon among the population studied. The most commonly associated clinical symptom of viral diarrhea in this study was vomiting. Viral diagnostic tests are advocated for primary health care facilities in this locality.

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Section: Resultscontrasting

confidence: 90%

Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria

Imade

Eghafona

2015

International Journal of Microbiology

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“…The fact that PCR was used for detection of norovirus and that the less-sensitive ELISA was used for detection of adenovirus and rotavirus may have affected the results. In the present study, the prevalence of astrovirus was lower than that found by previous studies [13], which may be due not to the sensitivity of primers used but, rather, to the low-prevalence season encompassed by the study period, because we detected astrovirus in 4.1% (33/812) of children hospitalized with gastroenteritis during 2004 [14].…”

Section: Discussioncontrasting

confidence: 84%

Detection of Human Bocavirus in Children Hospitalized because of Acute Gastroenteritis

Lee¹,

et al. 2007

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The idea that human bocavirus (hBoV) infection possibly plays a role in gastroenteritis has been suggested because of the frequent manifestation of gastrointestinal symptoms. The purpose of this study was to investigate the prevalence of hBoV in children with gastroenteritis. We studied the etiologic agents in 962 children hospitalized with gastroenteritis. Viral etiologic agents were detected by enzyme-linked immunosorbent assay or reverse-transcriptase polymerase chain reaction. A viral agent was found in 44.4% of the study population: rotavirus, norovirus, adenovirus, and astrovirus were detected in 25.7%, 13.7%, 3.0%, and 1.1% of the study population, respectively; hBoV was detected in 0.8%, which suggests that it might play a minor role in gastroenteritis.Acute gastroenteritis is one of the most common diseases requiring hospitalization of children. Group A rotavirus, norovirus, enteric adenovirus, and astrovirus are known to be important viral etiologic agents of gastroenteritis in children, and their detection is due to the use of improved diagnostic methods [1]. However, the etiologic agents are still undiagnosed in more than half of the patients with gastroenteritis, despite improvements in diagnostic technology.In 2005, human bocavirus (hBoV) was identified in children with acute respiratory-tract infections [2]. Although hBoV has been detected frequently in children with upper-respiratory-tract infection, lower-respiratory-tract infection (LRTI), and asthma exacerbation, the clinical spectrum of hBoV and the role that it plays in these infections is not certain [3][4][5][6]. In previous studies, hBoV has been reported to be associated with gastrointestinal symptoms in 11%-29% of patients [7-

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“…Our results were comparable to those from the above two studies as well as to results from a tertiary hospital (Seoul National University hospital) where the average age of astrovirus-positive children was 20.6±15.4 months [9]. From the above analyses, it can be concluded that astroviruses are important pathogens associated with acute gastroenteritis in infants, especially below 2 yr [3-5]. All feces and rectal swabs were obtained from outpatients at six hospitals, of which one was a primary hospital (AM center), three were secondary hospitals (SW hospital, NP hospital, and NM center), and two were tertiary hospitals (SG and EJ hospitals).…”

supporting

confidence: 88%

Prevalence of Human Astrovirus in Patients with Acute Gastroenteritis

Ham

Jang

et al. 2014

Ann Lab Med

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The prevalence of human astroviruses was tested in patients with acute gastroenteritis by using conventional duplex reverse transcription (RT)-PCR and electrophoresis. Diarrheal fecal samples were collected from 9,597 patients at local hospitals in Seoul. The prevalence of astroviruses was 1.0% (94/9,597 patients; mostly infants), and that of sapoviruses was 0.1% (14/9,597 patients). Age- and gender-wise analyses were carried out on 29 astrovirus-positive patients having complete information on file regarding their age, gender, and other particulars. The results were higher in patients of ages 0 to 14 yr, and 69.0% of the astrovirus-positive patients were females, of which 69.2% were infants (0 to 12 months), and 61.5% were 1-4 yr old. Notably, in the case of 5 to 78-yr-old acute gastroenteritis patients, 100% were females.

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Molecular Epidemiology of Human Astrovirus Infection in Hospitalized Children with Acute Gastroenteritis

Cited by 9 publications

References 0 publications

Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria

Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria

Detection of Human Bocavirus in Children Hospitalized because of Acute Gastroenteritis

Prevalence of Human Astrovirus in Patients with Acute Gastroenteritis

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