Molecular epidemiology of dengue fever cases imported into Romania between 2008 and 2013

Dinu, Sorin; Pănculescu-Gătej, Ioana R.; Florescu, Simin Aysel; Popescu, Corneliu Petru; Sîrbu, Anca; Oprişan, Gabriela; Bădescu, Daniela; Franco, Leticia; Ceianu, Cornelia Svetlana

doi:10.1016/j.tmaid.2014.11.001

Cited by 11 publications

(11 citation statements)

References 28 publications

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“…Between 2008 and 2012, however, DENV‐1 become the dominant serotype in most Indonesian regions (Table ). Data of traveller‐associated dengue from Australia, Taiwan, Germany, and Romania support this finding. A comprehensive study conducted in Surabaya found that the serotype shift from DENV‐2 to DENV‐1 occurred in late 2008 .…”

Section: Resultsmentioning

confidence: 55%

“…A full assessment of the 120 references resulted in the exclusion of 53 references due to the following: full texts were unavailable, and the available abstracts did not include adequate information to satisfy our outcome, the full text did not include adequate or complete serotype data, and nonstandard methods were used for serotyping. This resulted in 67 eligible studies, of which 13 references were from national journals . An additional 11 studies were included from reference list .…”

Section: Resultsmentioning

confidence: 99%

“…In total, 78 eligible studies were included for DENV serotype analysis . Of all the eligible studies, four studies were conducted based on mosquito isolates while the remaining studies assessed DENV isolates from human samples . Sixty two studies investigated dengue cases among local inhabitants of Indonesia,…”

Section: Resultsmentioning

confidence: 99%

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Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Harapan

Michie

Yohan

et al. 2019

Reviews in Medical Virology

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Although epidemiological and molecular epidemiological (serotype, genotype, and lineage information) data are available for several major cities in Indonesia, there is yet to be a comprehensive national study of dengue in Indonesia over time. This study was conducted to provide a comprehensive epidemiology of circulating dengue viruses (DENV) in Indonesia between 1973 and 2016. This was conducted through a systematic review of the literature and phylogenetic analysis of available DENV sequences. Available data from National Disease Surveillance System have indicated an increasing trend of dengue incidence in Indonesia over the past 50 years. Incidence rates appear to be cyclic, peaking approximately every 6 to 8 years. In contrast, the case fatality rate has decreased approximately by half with each decade since 1980.Over this 50-year time span, serotype shifts, genotype displacement within DENV-1 and DENV-2, and introduction of DENV-1 and DENV-3 genotype from other countries occurred. These events were associated with increased incidence of dengue cases. Our study also provides a valuable national snapshot of DENV genetic diversity in Indonesia that may contribute to development of more effective dengue vaccine compositions for the region.

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Section: Resultsmentioning

confidence: 55%

Section: Resultsmentioning

confidence: 99%

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Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Harapan

Michie

Yohan

et al. 2019

Reviews in Medical Virology

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“…The results of our dengue seroprevalence study on the population of Madeira Island are in agreement with investigations made during or directly after the outbreak. The extent of the outbreak and the fact that Madeira is a favourite tourist destination led to 81 exported cases to mainland Europe after returning from Madeira: 11 cases to mainland Portugal and 70 in other European countries [18] including Finland [32], Belgium [33], Romania [34], Germany and the UK [35]. Partial sequencing and phylogenetic investigations of autochthonous cases from Madeira and imported cases to other European countries identified DENV serotype 1 (DENV-1) genotype V as the causative agent of the outbreak [32, 36], highly likely imported from Venezuela [20, 34].…”

Section: Discussionmentioning

confidence: 99%

First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation

et al. 2019

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BackgroundIn 2012, the first dengue virus outbreak was reported on the Portuguese island of Madeira with 1080 confirmed cases. Dengue virus of serotype 1 (DENV-1), probably imported from Venezuela, caused this outbreak with autochthonous transmission by invasive Aedes aegypti mosquitoes.ResultsWe investigated the seroprevalence among the population on Madeira Island four years after the outbreak. Study participants (n = 358), representative of the island population regarding their age and gender, were enrolled in 2012 in a cross-sectional study. Dengue antibodies were detected with an in-house enzyme-linked immunosorbent assay (ELISA) using the dimer of domain III (ED3) of the DENV-1 envelope protein as well as commercial Panbio indirect and capture IgG ELISAs. Positive ELISA results were validated with a neutralization test. The overall seroprevalence was found to be 7.8% (28/358) with the in-house ELISA, whereas the commercial DENV indirect ELISA detected IgG antibodies in 8.9% of the individuals (32/358). The results of the foci reduction neutralization test confirmed DENV-1 imported from South America as the causative agent of the 2012 epidemic. Additionally, we found a higher seroprevalence in study participants with an age above 60 years old and probable secondary DENV infected individuals indicating unreported dengue circulation before or after 2012 on Madeira Island.ConclusionsThis study revealed that the number of infections might have been much higher than estimated from only confirmed cases in 2012/2013. These mainly DENV-1 immune individuals are not protected from a secondary DENV infection and the majority of the population of Madeira Island is still naïve for DENV. Surveillance of mosquitoes and arboviruses should be continued on Madeira Island as well as in other European areas where invasive vector mosquitoes are present.Electronic supplementary materialThe online version of this article (10.1186/s13071-019-3357-3) contains supplementary material, which is available to authorized users.

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“…Travel to and from endemic areas of dengue and chikungunya viruses is steadily increasing. Dengue-imported cases, including viremic persons, have been diagnosed in our laboratory (Dinu et al 2015). Stable populations of Ae.…”

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confidence: 99%

Established Population of the Invasive Mosquito SpeciesAedes albopictusin Romania, 2012–14

Prioteasa

Dinu

Fălcuță

et al. 2015

Journal of the American Mosquito Control Association

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During an entomological investigation carried out in Bucharest and surroundings in fall of 2012, 45 adult mosquitoes (38 females and 7 males) of Aedes albopictus were collected in a neighborhood from the southern area of the city. The morphological identification of the species was further confirmed by sequencing 2 mitochondrial DNA markers: the cytochrome c oxidase subunit I and NADH dehydrogenase subunit 5 genes. Aedes albopictus was collected again in 2013 in the same area from July until October. During late summer the species was found also in another location in the city, downtown Bucharest. Larvae were found in water barrels and other types of household containers, as well as in rain catch basins. In 2014, following a nuisance complaint of a Bucharest inhabitant, the entomological investigation found aggressive Ae. albopictus adults on his property that harbored many mosquito larvae in container-type breeding habitats. These findings are the 1st records of this invasive species and of its breeding population in Romania, and show maintenance of the species over 2 winter seasons. Surveillance of the species outside the area of the capital city was not performed, therefore it is not known whether Ae. albopictus has been introduced in other regions of the country. The presence of Ae. albopictus has been reported every year (2012-14) to competent public health authorities, stressing on the importance of surveillance and of implementation of control measures.

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Molecular epidemiology of dengue fever cases imported into Romania between 2008 and 2013

Cited by 11 publications

References 28 publications

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation

Established Population of the Invasive Mosquito SpeciesAedes albopictusin Romania, 2012–14

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