Molecular epidemiology of antimicrobial resistance in central africa: A systematic review

Dikoumba, Annicet-Clotaire; Onanga, Richard; Mangouka, Laurette G.; Boundenga, Larson; Ngoungou, Edgard-Brice; Godreuil, Sylvain

doi:10.1099/acmi.0.000556.v5

Cited by 4 publications

(2 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the Democratic Republic of Congo, OXA-48-, KPC-, VIM-, IMP-and NDM-encoding genes were found in wastewater and drinking water. No data were available for the other included countries [159].…”

Section: Resultsmentioning

confidence: 99%

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Chelaru,

Muntean,

Hogea

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) is a worldwide healthcare problem. Multidrug-resistant organisms (MDROs) can spread quickly owing to their resistance mechanisms. Although colonized individuals are crucial for MDRO dissemination, colonizing microbes can lead to symptomatic infections in carriers. Carbapenemase-producing Enterobacterales (CPE) are among the most important MDROs involved in colonizations and infections with severe outcomes. This review aimed to track down the first reports of CPE in Africa, describe their dissemination throughout African countries and summarize the current status of CRE and CPE data, highlighting current knowledge and limitations of reported data. Two database queries were undertaken using Medical Subject Headings (MeSH), employing relevant keywords to identify articles that had as their topics beta-lactamases, carbapenemases and carbapenem resistance pertaining to Africa or African regions and countries. The first information on CPE could be traced back to the mid-2000s, but data for many African countries were established after 2015–2018. Information is presented chronologically for each country. Although no clear conclusions could be drawn for some countries, it was observed that CPE infections and colonizations are present in most African countries and that carbapenem-resistance levels are rising. The most common CPE involved are Klebsiella pneumoniae and Escherichia coli, and the most prevalent carbapenemases are NDM-type and OXA-48-type enzymes. Prophylactic measures, such as screening, are required to combat this phenomenon.

show abstract

Section: Resultsmentioning

confidence: 99%

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Chelaru,

Muntean,

Hogea

et al. 2024

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Antimicrobial resistance (AMR) is a global One Health challenge affecting the health of humans and domestic animals and is spreading to natural environments, including wildlife [1][2][3]. For example, extended-spectrum beta-lactamases (ESBLs) and carbapenemase (CARBA)-producing Enterobacterales, pathogens of critical importance for public health, have been reported in wildlife living closely to humans such as gulls, storks, bats, and rodents [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Public Health Implications of Antimicrobial Resistance in Wildlife at the One Health Interface

Benavides,

Salgado-Caxito,

Torres

et al. 2024

One Health 2023

Self Cite

View full text Add to dashboard Cite

show abstract

A comprehensive study on Geranium robertianum L. antibacterial potential

Stanković,

Ristivojević,

Ivković

et al. 2024

Journal of Applied Microbiology

View full text Add to dashboard Cite

Aims The research aimed to optimize the ultrasound-assisted extraction of secondary metabolites and antibacterial activity of the plant species Geranium robertianum. The phytochemical profiles of the optimized extracts, as well as their antibacterial and synergistic activity with an antibiotic, their potential mechanisms of action and cytotoxicity, were examined. Methods and results Response Surface Methodology was used to optimize extraction conditions. Optimized ethanol and acetone extract were tested via microdilution, checkerboard, time-kill kinetics and cell membrane permeability methods. The extracts displayed broad antibacterial activity with minimum inhibitory concentrations ranging from 1.25 to 20 mg ml−1. In addition, the extract synergistically reacted with gentamicin against gentamicin-resistant strains of E. coli and S. aureus enhancing the efficacy of the antibiotic up to 32-fold. The extracts demonstrated strain-dependent bactericidal activity in a 24-hour time interval. They increase the permeability of the cell membrane thus disrupting its normal functioning. The cytotoxic concentration (CC50) on human keratinocytes was 1771.24±5.78 µg ml−1 for ethanol extract, and 958.01±6.14 µg ml−1 for acetone extract. Kaempferol, ellagic acid, quercetin, and rutin were recognized as the main components in both extracts. Conclusions The findings of this study indicate that the extracts of G. robertianum can be considered as potential natural antibacterial agents in the control of microorganisms.

show abstract

Molecular epidemiology of antimicrobial resistance in central africa: A systematic review

Cited by 4 publications

References 95 publications

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Public Health Implications of Antimicrobial Resistance in Wildlife at the One Health Interface

A comprehensive study on Geranium robertianum L. antibacterial potential

Contact Info

Product

Resources

About