Molecular Epidemiology of Adenovirus Isolates from Patients Diagnosed with Intussusception in Melbourne, Australia

Selvaraj, Gowri; Kirkwood, Carl D.; Bines, Julie E; Buttery, Jim

doi:10.1128/jcm.01289-06

Cited by 26 publications

(18 citation statements)

References 21 publications

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“…A prospective case-control study showed that experiencing gastroenteritis during the 30 days before an IS diagnosis was associated with IS in children aged 0-59 months (odds ratio: 11.6; 95% CI: 3.2-41.2; p-value<0.001) (20). Although other risk factors for gastroenteritis were not explored in that study, results are consistent with other studies that identified bacterial and viral gastroenteritis as major risk factors for developing IS (21)(22)(23)(24)(25). While adenovirus is the primary causative agent frequently detected in IS cases, some studies demonstrated an association with rotavirus (8-10).…”

Section: Ge and Is But Not Between Fracture And Issupporting

confidence: 87%

Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States. Corresponding author: Corinne Willame, MPH, GSK, 20 Avenue Fleming, Wavre, Belgium

Willame,

Cheuvart,

Aris

et al. 2019

Preprint

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Background: The etiology of intussusception (IS), a serious medical condition of acute gastrointestinal obstruction, remains unclear. Limited evidence suggests a role for viral infections, including rotavirus infection. This study aimed to explore the risk of IS after rotavirus gastroenteritis (RV GE) in the first year of life, where the incidence of IS is highest. Methods: In this retrospective, self-controlled case series (SCCS), we assessed the risk of IS after RV GE in infants <1 year of age, using data extracted from administrative claims databases in the United States. Incidence rate ratios (IRR) of IS were calculated for the 7- and 21-day risk periods after RV GE (main analysis) or after fracture (sensitivity analysis using a control event) in subjects presenting with claims for these conditions. Post-hoc analyses were also performed. Results: Out of the 290,912,068 subjects screened, 42 subjects presented claims for RV GE and IS (RV GE group) and 66 presented claims for fracture and IS (fracture group). The IRR of IS after RV GE was 79.6 (95% confidence interval, CI: 38.6–164.4) in the 7-day risk period and 25.5 (95% CI: 13.2–49.2) in the 21-day risk period. The sensitivity analysis also showed an association between IS and fracture for the two risk periods: IRR was 6.1 (95% CI: 3.0–12.7) and 2.8 (95% CI: 1.5–5.4) in the 7- and 21-day risk periods, respectively, which suggested potential confounding such as by history of rotavirus vaccination, or a visit effect. Post-hoc analyses investigating these points did not confirm an association between fracture and IS, but still suggested a possible association between RV GE and IS. Conclusions: A temporal association between RV GE and IS was detected using the SCCS design in United States claims databases. However, due to some limitations identified through additional analyses, further studies are needed to confirm this association.

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Section: Ge and Is But Not Between Fracture And Issupporting

confidence: 87%

Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States. Corresponding author: Corinne Willame, MPH, GSK, 20 Avenue Fleming, Wavre, Belgium

Willame,

Cheuvart,

Aris

et al. 2019

Preprint

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“…27 However, if a given confounding variable remains stable over time, this would be controlled for automatically in the design itself. Moreover, our study did not take into account the reason for prescribing antibiotics, which may mask other possible causes of intussusception and be a source of potential confounders.…”

Section: Discussionmentioning

confidence: 99%

Association Between Medication and Intestinal Intussusception in Children

García¹,

Fuentes-Leonarte²,

Tenías³

et al. 2015

Pediatric Emergency Care

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“…1,2 Previous studies have identified the role of infection in intussusception, 3,4 with adenovirus being the most common infectious association and Yersinia being the most common bacterial association. [5][6][7][8][9] Yersinia intussusception was first identified in 1976 and we have identified 32 reported cases world-wide to date (Table 1). [10][11][12][13][14][15][16][17][18][19][20][21][22] Yersinia are facultative Gram-negative anaerobes with global distribution.…”

Section: Introductionmentioning

confidence: 99%

Yersinia intussusception: Case report and review

May

Piper

Boutlis

2013

J Paediatrics Child Health

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Intussusception is a recognised paediatric presentation in emergency department and primary care settings. The aetiology of intussusception is multifactorial and largely unknown but includes infection in some cases. Yersinia has been the most frequently cited bacterial association in children. Identifying Yersinia affects the role and choice of antibiotics in a child's treatment regimen. This article reports on Australia's first proven case of Yersinia enterocolitica intussusception, and reviews the clinical epidemiology of all known reported cases world-wide.

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Molecular Epidemiology of Adenovirus Isolates from Patients Diagnosed with Intussusception in Melbourne, Australia

Cited by 26 publications

References 21 publications

Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States. Corresponding author: Corinne Willame, MPH, GSK, 20 Avenue Fleming, Wavre, Belgium

Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States. Corresponding author: Corinne Willame, MPH, GSK, 20 Avenue Fleming, Wavre, Belgium

Association Between Medication and Intestinal Intussusception in Children

Yersinia intussusception: Case report and review

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