Molecular epidemiology of adenovirus infection among infants and children with acute gastroenteritis in Dhaka City, Bangladesh

Circulation of a Novel Pattern of Infections by Enteric Adenovirus Serotype 41 among Children below 5 Years of Age in Kolkata, India

“…Even though the prevalence rate was low in asymptomatic children, in both the symptomatic and asymptomatic groups of children, children under 2 years of age were found to be more susceptible to AdV-40/41 infection. Our result is consistent with the findings of epidemiological studies on enteric adenoviruses worldwide, in which adenovirus infection associated with acute gastroenteritis is reported predominantly in infants and young children (1,7,10,18,29,33,38,41). As reported in many studies, we also observed that the frequency of AdV-40/41 infection was high but sporadic during winter months (4,9,11,17,45).…”

“…As reported in many studies, we also observed that the frequency of AdV-40/41 infection was high but sporadic during winter months (4,9,11,17,45). Diarrheal outbreaks due to AdV-40/41 infection were reported to occur from November to January (10,41).…”

“…However, mixed infections with other pathogens as the cause of diarrhea in this case cannot be ruled out. In previous reports, a predominance of AdV-41 over AdV-40 has been shown (10,11,14,19,39,41). This trend may be associated with the higher pathogenicity of AdV-41 in these communities (24,52).…”

“…Epidemiological studies of adenovirus in infants and children with acute gastroenteritis have shown its importance in both developed and developing countries (6,10,11,17,18,23,31,39,43,49). Next to rotavirus, enteric adenovirus has been shown to be the most common cause of pediatric viral gastroenteritis in Kolkata (31).…”

Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof-of-concept study

“…In the present proof-ofconcept study, we used a similar approach to show that a resequencing microarray can also be applied to virus detection in stool specimens for patients with communityacquired gastroenteritis. The incidence of human adenovirus gastroenteritis in this cohort was about 7 %, which was similar to that in other studies on paediatric patients from different countries in Europe, Asia and Africa published in the last 5 years (median 3.3 %, range 1.9-19.9 %) (Li et al, 2005(Li et al, , 2009Fabiana et al, 2007;Silva et al, 2008;Dey et al, 2009;Jin et al, 2009). Such a high sensitivity of the resequencing microarray, using PCR as the standard, for human adenoviruses has been shown for respiratory specimens, conjunctival swabs and stool specimens.…”