Molecular Epidemiology in Neonatal Pasteurellosis

Wood, Andrew S.; Foraker, Elyse E.; Pentima, Cecilia Di

doi:10.1097/inf.0000000000000004

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Notably, one report of neonatal sepsis and meningitis from P. multocida may have implicated a cat's positive mouth culture in atraumatic animal transmission but molecular testing showed that the infant and cat strains were different. 16…”

Section: Discussionmentioning

confidence: 99%

Early-Onset Neonatal Sepsis Caused by Vertical Transmission of Pasteurella multocida

Scheurer

Fanta

Colbenson

et al. 2022

AJP Rep

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Background: Early onset neonatal sepsis contributes substantially to neonatal morbidity and mortality. Presenting signs and symptoms vary, and most causes are due to a limited number of common microbes. However, providers must also be cognizant of unusual pathogens when treating early onset sepsis. Case description: We report a case of a term neonate who presented with respiratory distress, lethargy, and hypoglycemia 5 hours after birth. He was treated for presumed early onset sepsis with blood culture revealing an unusual pathogen: Pasteurella multocida. Sepsis from this pathogen is a rarely reported cause of early onset neonatal sepsis. Our report is one of few that implicates vertical transmission with molecular diagnostic confirmation of Pasteurella multocida, subspecies septica. The neonate was treated with antibiotics and supportive care and recovered without ongoing complications. Conclusions: Providers should maintain an index of suspicion for rare causes of neonatal early onset sepsis. For these unusual cases, precise microbial identification enables understanding to provide best clinical care and anticipation of complications.

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Section: Discussionmentioning

confidence: 99%

Early-Onset Neonatal Sepsis Caused by Vertical Transmission of Pasteurella multocida

Scheurer

Fanta

Colbenson

et al. 2022

AJP Rep

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“…Fetuses, newborns, and young infants are often highly susceptible to unusual pathogens that may be relatively benign in adults. [1][2][3][4][5][6][7][8][9][10] The debate continues on whether these epidemiological differences arise in the unique strains of pathogens, 1,[11][12][13][14][15] immaturity of the immune system, [16][17][18] environmental factors in intensive care units [19][20][21] or in specific climatic conditions that allow these pathogens to reach larger numbers and/or densities. [22][23][24] These conditions have been difficult to treat as the infectious agents affect the fetus/neonate in utero and cannot be treated in a timely fashion, the candidate medications have limited efficacy, or the drugs have had unacceptable short-and long-term adverse effects.…”

mentioning

confidence: 99%

Editorial

Maheshwari¹,

Motta²,

Lui³

2023

Newborn

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Neonatal Pasteurella multocida subsp. septica Meningitis Traced to Household Cats: Molecular Linkage Analysis Using Repetitive-Sequence-Based PCR

et al. 2016

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e Pasteurella multocida is a rare cause of neonatal bacterial meningitis. We describe such a case and verify two household cats as the source of infection using repetitive-element PCR (rep-PCR) molecular fingering. CASE REPORTA 17-day-old boy was seen in the emergency department after a 2-day history of worsening fussiness, irritability, fever, and bilateral eye crusting of 7 days' duration. Upon presentation, his rectal temperature was 39.7°C, and his heart and respiratory rates were 149 beats/min and 44 breaths/min, respectively. Laboratory studies showed the following: hemoglobin, 15.7 g/dl; hematocrit, 44.6%; white blood cell (WBC) count, 18.2 bilateral/liter (neutrophils, 63%; lymphocytes, 23%; monocytes, 14%); platelet count, 379 ϫ 10 9 /liter; Na, 129 mmol/liter; K, 5.4 mmol/liter; chloride, 95 mmol/liter; CO 2 , 22 mmol/liter; blood urea nitrogen (BUN), 12 mg/dl; creatinine, Ͻ0.1 mg/dl; albumin, 4.0 g/dl; alkaline phosphatase, 648 U/liter; total bilirubin, 3.1 mg/dl; aspartate transaminase (AST), 61 U/liter; and alanine aminotransferase (ALT), 50 U/liter. Cerebrospinal fluid (CSF) studies showed 1,500 red blood cells/l, 20,822 WBCs/l (neutrophils, 73%; mononuclear cells, 27%), 7 mg/dl glucose, and 148 mg/dl protein. Gram stain showed many polymorphonuclear leukocytes, moderate mononuclear cells, and rare Gram-negative bacilli. Bacterial antigen was negative for Haemophilus influenzae type b, Streptococcus agalactiae, Streptococcus pneumoniae, Neisseria meningitidis (A, B/E, C, Y, and W135), and Escherichia coli K1. Cefotaxime, ampicillin, and acyclovir (one dose) were empirically started. He was transferred to the pediatric intensive care unit (PICU).On examination, the infant had a patent, slightly full anterior fontanelle and a right-sided middle ear effusion with mild tympanic membrane injection. He was tachycardic with a grade I-II/VI systolic murmur. There was full passive range of motion of all joints; none were red, warm, or swollen. Kernig and Brudzinski signs were negative. Moro and stepping reflexes were present. There was no neck stiffness, and he had good motor tone. Ampicillin was discontinued, and he was treated with cefotaxime (200 mg/kg body weight/day every 8 h) and gentamicin (2.5 mg/kg/ dose every 8 h). An echocardiogram revealed physiologic peripheral pulmonic stenosis and a patent foramen ovale. The xTAG respiratory viral panel (Luminex, Austin, TX) was negative. By history, the neonate was born at term to a 35-year-old GI (primigravida) mother who had no illnesses during her pregnancy and received no antibiotics; she developed hypertension late in pregnancy and was induced at 39 weeks' gestation. She delivered by cesarean section 10.5 h after rupture of membranes. She was screened during pregnancy for HIV-1 antibodies, hepatitis B surface antigen, VDRL test, Chlamydia trachomatis, Neisseria gonorrhoeae, and group B Streptococcus anogenital carriage; all tests were negative. The neonate lived with his mother, father, and maternal grandmother; a 10-year-old paternal half-brother staye...

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Molecular Epidemiology in Neonatal Pasteurellosis

Cited by 3 publications

References 6 publications

Early-Onset Neonatal Sepsis Caused by Vertical Transmission of Pasteurella multocida

Early-Onset Neonatal Sepsis Caused by Vertical Transmission of Pasteurella multocida

Editorial

Neonatal Pasteurella multocida subsp. septica Meningitis Traced to Household Cats: Molecular Linkage Analysis Using Repetitive-Sequence-Based PCR

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