Molecular epidemiology and genetic diversity of Mycobacterium tuberculosis complex in referral health centers of Bamako, Mali: What is new?

Kone, Bourahima; Somboro, Anou M.; Kone, Mahamadou; Holl, Jane L.; Baya, Bocar; Dabitao, Djeneba; Diallo, Dramane; Diarra, Bassirou; Koné, A.; Sarro, Yeya dit Sadio; Sanogo, Moumine; Togo, Antieme Cg; Murphy, Robert L.; Diallo, Souleymane; Coulibaly, Nouhoum; Camara, Fatoumata; Samake, Seydou; Diakité, Mahamadou; Doumbia, Seydou; Maiga, Mamoudou

doi:10.1016/j.ijid.2022.01.061

Cited by 2 publications

(3 citation statements)

References 24 publications

(30 reference statements)

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“…The standard treatment for tuberculosis has demonstrated improved clinical and functional outcomes, resulting in patient recovery 14 . While the 82% success rate is positive, the 14% of cases lost to follow-up and 124 deaths underscore persistent gaps and challenges in The disparity between positive outcomes and negative consequences highlights the importance of improving therapeutic approaches.…”

Section: Discussionmentioning

confidence: 99%

“…While the 82% success rate is positive, the 14% of cases lost to follow-up and 124 deaths underscore persistent gaps and challenges in The disparity between positive outcomes and negative consequences highlights the importance of improving therapeutic approaches. It is conceivable to reduce these disparities by using treatments that promote patient cooperation, enhance medical follow-up, and address risk factors associated with loss 13,14 . The importance of considering sociocultural factors in prevention programs is emphasized by mentioning the male preference in tuberculosis cases.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of the Therapeutic Approach to Drug-Sensitive Tuberculosis in Morocco: Retrospective Study from 2014 to 2017

Bejja,

Dahou,

Aboulhoda

et al. 2024

Bangladesh J Med Sci

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In countries like Morocco, drug-sensitive tuberculosis remains a major public health burden. Effective management of this condition is crucial, not only to achieve positive therapeutic outcomes for patients but also to curb its emergence and transmission. This study presents a detailed analysis of the therapeutic approach to drug-sensitive tuberculosis in Morocco. This retrospective study provides an overview of the therapeutic protocol used to treat drug-sensitive tuberculosis. The study examined all tuberculosis patients registered at the Tuberculosis and Respiratory Diseases Diagnostic Center in Kenitra from 2014 to 2017. A total of 5207 tuberculosis cases were recorded, with men comprising the majority of patients (63%) in this group, with a sex ratio of 1.7. The most affected age groups were 15 to 24 years and 25 to 34 years. Urban areas had a representation of 53%. The study revealed that 54% of cases were pulmonary, and extrapulmonary tuberculosis accounted for 46%. There were two main stages to the treatment regimens recommended by the WHO. During the initial phase, 96% of patients received a two-month quadritherapy (for new cases), 3% received a three-month regimen (for retreatment cases), and 2% received a three-drug therapy (for those under 15 years). This phase was followed by a continuation phase (bitherapy) lasting four to ten months. 82% of cases showed positive progression, 13% of patients experienced loss to follow-up, 1% had transfers out, and 2% of patients died. The study emphasizes the importance of integrating patient support, education on treatment, and the use of new technologies to enhance the monitoring and follow-up of tuberculosis patients. These measures could help reduce the morbidity and mortality associated with tuberculosis, contributing to overall health improvement. Bangladesh Journal of Medical Science Vol. 23 No. 02 April’24 Page : 521-526

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of the Therapeutic Approach to Drug-Sensitive Tuberculosis in Morocco: Retrospective Study from 2014 to 2017

Bejja,

Dahou,

Aboulhoda

et al. 2024

Bangladesh J Med Sci

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“…Tuberculosis (TB) caused by Mycobacterium tuberculosis infection remains a serious worldwide health concern in terms of infection incidence and associated mortality ( Kone et al, 2022 ), despite the significant improvement in the situation; for example, the global mortality of TB considerably reduced by 47% from 1990 to 2015 through the global efforts of many countries, including China ( Wang et al, 2014 ; World Health Organization, 2015 ). However, the incidence of tuberculosis is on the rise again; for instance, its global incidence rate in 2021 increased by 3.6% compared with that in 2020 ( Ding et al, 2020 ; World Health Organization, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Regulatory role of Mycobacterium tuberculosis MtrA on dormancy/resuscitation revealed by a novel target gene-mining strategy

Fu,

Wan,

Memon

et al. 2024

Front. Microbiol.

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IntroductionThe unique dormancy of Mycobacterium tuberculosis plays a significant role in the major clinical treatment challenge of tuberculosis, such as its long treatment cycle, antibiotic resistance, immune escape, and high latent infection rate.MethodsTo determine the function of MtrA, the only essential response regulator, one strategy was developed to establish its regulatory network according to high-quality genome-wide binding sites.Results and discussionThe complex modulation mechanisms were implied by the strong bias distribution of MtrA binding sites in the noncoding regions, and 32.7% of the binding sites were located inside the target genes. The functions of 288 potential MtrA target genes predicted according to 294 confirmed binding sites were highly diverse, and DNA replication and damage repair, lipid metabolism, cell wall component biosynthesis, cell wall assembly, and cell division were the predominant pathways. Among the 53 pathways shared between dormancy/resuscitation and persistence, which accounted for 81.5% and 93.0% of the total number of pathways, respectively, MtrA regulatory genes were identified not only in 73.6% of their mutual pathways, but also in 75.4% of the pathways related to dormancy/resuscitation and persistence respectively. These results suggested the pivotal roles of MtrA in regulating dormancy/resuscitation and the apparent relationship between dormancy/resuscitation and persistence. Furthermore, the finding that 32.6% of the MtrA regulons were essential in vivo and/or in vitro for M. tuberculosis provided new insight into its indispensability. The findings mentioned above indicated that MtrA is a novel promising therapeutic target for tuberculosis treatment since the crucial function of MtrA may be a point of weakness for M. tuberculosis.

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Molecular epidemiology and genetic diversity of Mycobacterium tuberculosis complex in referral health centers of Bamako, Mali: What is new?

Cited by 2 publications

References 24 publications

Analysis of the Therapeutic Approach to Drug-Sensitive Tuberculosis in Morocco: Retrospective Study from 2014 to 2017

Analysis of the Therapeutic Approach to Drug-Sensitive Tuberculosis in Morocco: Retrospective Study from 2014 to 2017

Regulatory role of Mycobacterium tuberculosis MtrA on dormancy/resuscitation revealed by a novel target gene-mining strategy

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