Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases

Tomasovic, Luke M.; Liu, Kathy; VanDyke, Derek; Fabilane, Charina S.; Spangler, Jamie B.

doi:10.1007/s40259-023-00635-0

Cited by 1 publication

(1 citation statement)

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“…Moreover, SA increased IL‐2, IL‐4 and IL‐10 levels. IL‐2 regulates the immune response by stimulating the growth of T and B cells and inducing Th1 cell differentiation, 35 whereas IL‐4 plays a role in Th‐2‐mediated immune response 36 . IL‐10 participates in B cell‐ and T cell‐mediated adaptive immunity by promoting B lymphocyte proliferation and corresponding antibody production 37 .…”

Section: Discussionmentioning

confidence: 99%

Sciadonic acid ameliorates cyclophosphamide‐induced immunosuppression by modulating the immune response and altering the gut microbiota

Chen,

Jiang,

Yao

et al. 2024

J Sci Food Agric

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BACKGROUNDCyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long‐term Cy treatment can cause immunosuppression and intestinal mucosal damage. The intestinal mucosal barrier and gut flora play important roles in regulating host metabolism, maintaining physiological functions and protecting immune homeostasis. Dysbiosis of the intestinal flora affects the development of the intestinal microenvironment, as well as the development of various external systemic diseases and metabolic syndrome.RESULTSThe present study investigated the influence of sciadonic acid (SA) on Cy‐induced immunosuppression in mice. The results showed that SA gavage significantly alleviated Cy‐induced immune damage by improving the immune system organ index, immune response and oxidative stress. Moreover, SA restored intestinal morphology, improved villus integrity and activated the nuclear factor κB signaling pathway, stimulated cytokine production, and reduced serum lipopolysaccharide (LPS) levels. Furthermore, gut microbiota analysis indicated that SA increased t beneficial bacteria (Alistipes, Lachnospiraceae_NK4A136_group, Rikenella and Odoribacter) and decreased pathogenic bacteria (norank‐f‐Oscillospiraceae, Ruminococcus and Desulfovibrio) to maintain intestinal homeostasis.CONCLUSIONThe present study provided new insights into the SA regulation of intestinal flora to enhance immune responses. © 2024 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%