“…A variety of structures with unique structural [9,10], optical [11,12], electronic [13], magnetic [14], and catalytic [15] properties have been exploited in the areas of cancer imaging [2,[16][17][18][19], diagnostics [6,20,21], and treatment [22][23][24][25][26][27][28][29][30]. Noble metal nanoparticles provide remarkable opportunities in these applications due to their inherently low toxicity [31][32][33] and strongly enhanced optical properties associated with localized surface plasmon resonance [34][35][36]. The enhanced electromagnetic field surrounding such particles gives rise to large absorption, Rayleigh (Mie) scattering, raman scattering, and twophoton luminescence cross-sections, properties which have been utilized in photothermal cancer therapy [24][25][26][27][28][29][30] (PTT), surface enhanced Raman detection [37][38][39] (SERS), and diagnostic imaging [17][18][19][20] applications...…”