Molecular Effects of Fractional Carbon Dioxide Laser Resurfacing on Photodamaged Human Skin

A Comparison of the Scar Prevention Effect Between Carbon Dioxide Fractional Laser and Pulsed Dye Laser in Surgical Scars

“…The proinflammatory cytokines were proposed to induce the expression of matrix metalloproteinases, which seem to play a key role in the denaturation, degradation, and reorganization of collagen, and which help to reduce the extracellular matrix deposition. 22,23 Assisted by the above mechanisms, AFL was assumed to be more effective than PDL in the improvement of pliability and thickness in our study.…”

Use of a Fractional Ablative 10.6- μm Carbon Dioxide Laser in the Treatment of a Morphea-Related Contracture

“…Prignano et al 9 studied how fractional ablative carbon dioxide lasers modulate the woundhealing process and concluded that carbon dioxideinduced dermal injury is more physiological by restoring the balance among cytokines that encourage normal healing, as opposed to hypertrophic or keloidal scarring. The precise mechanism and biochemical effects of fractional ablative lasers have yet to be determined, but Reilly et al 10 reported that these lasers modulate collagen production via upregulation of cytokines and matrix metalloproteinases in a pattern similar to that previously demonstrated with conventional ablative laser devices.…”

Residual Scarring From Hidradenitis Suppurativa: Fractionated CO2 Laser as a Novel and Noninvasive Approach

“…[20][21][22] Although the exact histopathologic mechanisms are still being elucidated, it appears that the benefits of fractional photothermolysis are likely related to a relative normalization of dermal and epidermal architecture over time guided by a multitude of temporally related mediators such as heat shock proteins, growth factors, matrix metalloproteinases, and microRNAs. [22][23][24][25][26][27] Nonablative fractional resurfacing has been reported for treatment of certain types of scarring in children. 28 However, the literature is sparse in the use of ablative fractional resurfacing (AFR) for the treatment of scarring in the pediatric population.…”