Molecular dynamics study on the stability of amorphous Ar inside a nanopore

Nishio, Keiko; Kōga, Junichiro; Yamaguchi, Toshio; Yonezawa, Fumiko

doi:10.1016/j.jnoncrysol.2007.05.114

Cited by 4 publications

(1 citation statement)

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“…In spite of the widespread use of nanoporous materials in the drug industry, one important feature of these substances is still unexploited. Namely, these materials may be able to significantly suppress devitrification of compounds which easily crystallize. , According to the classical theory of homogeneous nucleation, a crystal can only be formed and grow when a critical nucleation size is reached . Thus, if a cluster of molecules are confined to suitable small pores, their nucleation and crystal growth should be prevented.…”

Section: Introductionmentioning

confidence: 99%

Stabilization of the Amorphous Ezetimibe Drug by Confining Its Dimension

et al. 2016

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The purpose of this paper is to investigate the influence of nanoconfinement on the molecular mobility, as well as on the physical stability, of amorphous ezetimibe drug. Two guest/host systems, ezetimibe-Aeroperl 300 and ezetimibe-Neusilin US2, were prepared and studied using various experimental techniques, such as X-ray diffraction (XRD), differential scanning calorimetry (DSC), and broadband dielectric spectroscopy (BDS). Our investigation has shown that the molecular mobility of the examined anticholesterol agent incorporated into nanopore matrices strongly depends on the pore size of the host system. Moreover, it was found that the amorphous ezetimibe confined in 30 nm pores of Aeroperl 300 has a tendency to recrystallize, while the drug incorporated into the smaller--5 nm--pores of Neusilin US2 is not able to crystallize. It has been shown that this significant stabilization of ezetimibe drug can be achieved by an interplay of three factors: changes in molecular dynamics of the confined amorphous drug, the immobilization effect of pore walls on a part of ezetimibe molecules, and the use of host materials with pores that are smaller than the critical size of the drug crystal nuclei.

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Section: Introductionmentioning

confidence: 99%