Molecular Dynamics Simulation of Hydrogels Based on Phosphorylcholine-Containing Copolymers for Soft Contact Lens Applications

Filipecka-Szymczyk, Katarzyna; Makowska-Janusik, Malgorzata; Marczak, Wojciech

doi:10.3390/molecules28186562

Cited by 2 publications

(1 citation statement)

References 77 publications

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“…They are also a match for imaging in bio-nanotechnology, spanning the length and temporal scales up to several nanoseconds for atomistic approaches and much longer for coarser descriptions. Recent advancements in the field of computer science, coupled with the integration of diverse approaches for conducting multi-scale in silico research, have facilitated the advancement in the development of novel medical devices that exhibit enhanced features [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions

Ioniță,

Vlăsceanu,

Toader

et al. 2023

JPM

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In the advent of an increasingly aging population and due to the popularity of electronic devices, ocular conditions have become more prevalent. In the world of medicine, accomplishing eye medication administration has always been a difficult task. Despite the fact that there are many commercial eye drops, most of them have important limitations, due to quick clearance mechanisms and ocular barrers. One solution with tremendous potential is the contact lens used as a medication delivery vehicle to bypass this constraint. Therapeutic contact lenses for ocular medication delivery have attracted a lot of attention because they have the potential to improve ocular bioavailability and patient compliance, both with minimal side effects. However, it is essential not to compromise essential features such as water content, optical transparency, and modulus to attain positive in vitro and in vivo outcomes with respect to a sustained drug delivery profile from impregnated contact lenses. Aside from difficulties like drug stability and burst release, the changing of lens physico-chemical features caused by therapeutic or non-therapeutic components can limit the commercialization potential of pharmaceutical-loaded lenses. Research has progressed towards bioinspired techniques and smart materials, to improve the efficacy of drug-eluting contact lenses. The bioinspired method uses polymeric materials, and a specialized molecule-recognition technique called molecular imprinting or a stimuli–responsive system to improve biocompatibility and support the drug delivery efficacy of drug-eluting contact lenses. This review encompasses strategies of material design, lens manufacturing and drug impregnation under the current auspices of ophthalmic therapies and projects an outlook onto future opportunities in the field of eye condition management by means of an active principle-eluting contact lens.

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Section: Introductionmentioning

confidence: 99%

Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions

Ioniță,

Vlăsceanu,

Toader

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

Advances in Therapeutic Contact Lenses for Different Ocular Condition Management

Ioniță,

Vlăsceanu,

Toader

et al. 2023

Preprint

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The number of people affected by eye conditions is growing every year, due to the popularity of electronic devices and an aging population. In the world of medicine, accomplishing eye medication administration has always been a difficult task. Despite the fact that there are many eye drops on the market, most of them have important limitations due to quick clearance mechanisms and ocular barriers. One solution with tremendous potential is the contact lens used as medication delivery vehicle to bypass this constraint. Therapeutic contact lenses for ocular medication delivery have attracted a lot of attention because they have the potential to improve ocular bioavailability, patient compliance, and reduce side effects. However, it is essential not to compromise essential features such as water content, optical transparency, and modulus in order to target successful in vitro and in vivo sustained drug delivery profile from impregnated contact lenses. Aside from difficulties like drug stability and burst release, the changing of lens physical and chemical properties caused by therapeutic or non-therapeutic components can limit the commercialization potential of pharmaceutical-loaded lenses. Research has progressed towards bioinspired techniques and smart materials to improve the efficacy of drug-eluting contact lenses. The bioinspired method uses bioinspired polymeric materials to improve biocompatibility, a specialized molecule recognition technique called molecular imprinting, or a stimuli-responsive system to improve biocompatibility and support drug delivery efficacy of drug-eluting contact lenses. This review encompasses strategies of material design, lens manufacturing and drug impregnation under the current auspices in ophthalmic therapies and projects an outlook onto future opportunities in the field of eye conditions management by means of active principles-eluting contact lens.

show abstract

Molecular Dynamics Simulation of Hydrogels Based on Phosphorylcholine-Containing Copolymers for Soft Contact Lens Applications

Cited by 2 publications

References 77 publications

Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions

Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions

Advances in Therapeutic Contact Lenses for Different Ocular Condition Management

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