“…When the drug molecule exerts its efficacy, electrons are provided by the three-membered phenanthrene ring in rosin and the thiophene ring, oxime ester, and nitro groups receive electrons. At this time, the drug interacts with the acceptor to form an electron transfer complex, thereby achieving the antifungal effect …”
Section: Results
and Discussionmentioning
confidence: 99%
“…At this time, the drug interacts with the acceptor to form an electron transfer complex, thereby achieving the antifungal effect. 20 q O max and q N max are electrostatic descriptors. 21 The nitro group, the O and N atoms in the oxime structure, and the carbon atoms on the phenanthrene and thiophene rings of compound 4f form a region where negative charges are relatively concentrated, and this region is the most likely to bind to the positively charged region of the acceptor.…”
Inspired
by the application of natural products against pathogenic
fungi, two series of dehydroabietyl oxime ester derivatives were synthesized
using rosin as a raw material. Based on the evaluation and screening
of in vitro antifungal activities against Botrytis cinerea (B. cinerea), Sclerotinia sclerotiorum, Valsa mali, Rhizoctonia solani, Fusarium oxysporum, and Alternaria alternata, compound 4f exhibited
the best antifungal activity against B. cinerea, and its EC50 was 0.798 mg/L, which was lower than that
of the positive control trifloxystrobin (1.112 mg/L). The in vivo antifungal activity results showed that 4f had satisfactory protective and curative effects on tomato. Physiological
and biochemical studies showed that the action mechanism of compound 4f against B. cinerea is to
change the morphology and the ultrastructure of the mycelium, increase
the permeability of the cell membrane, and cause nucleus and mitochondrial
dysfunction, thus leading to apoptosis. In addition, qualitative and
quantitative structure–activity relationship studies showed
that the inductive and conjugative interactions between compound 4f and the target receptor form an electron transfer process,
thereby achieving an antifungal effect. These results indicated that
compound 4f, which was derived from the natural product
rosin, is a novel potential fungicidal candidate against B. cinerea.
“…When the drug molecule exerts its efficacy, electrons are provided by the three-membered phenanthrene ring in rosin and the thiophene ring, oxime ester, and nitro groups receive electrons. At this time, the drug interacts with the acceptor to form an electron transfer complex, thereby achieving the antifungal effect …”
Section: Results
and Discussionmentioning
confidence: 99%
“…At this time, the drug interacts with the acceptor to form an electron transfer complex, thereby achieving the antifungal effect. 20 q O max and q N max are electrostatic descriptors. 21 The nitro group, the O and N atoms in the oxime structure, and the carbon atoms on the phenanthrene and thiophene rings of compound 4f form a region where negative charges are relatively concentrated, and this region is the most likely to bind to the positively charged region of the acceptor.…”
Inspired
by the application of natural products against pathogenic
fungi, two series of dehydroabietyl oxime ester derivatives were synthesized
using rosin as a raw material. Based on the evaluation and screening
of in vitro antifungal activities against Botrytis cinerea (B. cinerea), Sclerotinia sclerotiorum, Valsa mali, Rhizoctonia solani, Fusarium oxysporum, and Alternaria alternata, compound 4f exhibited
the best antifungal activity against B. cinerea, and its EC50 was 0.798 mg/L, which was lower than that
of the positive control trifloxystrobin (1.112 mg/L). The in vivo antifungal activity results showed that 4f had satisfactory protective and curative effects on tomato. Physiological
and biochemical studies showed that the action mechanism of compound 4f against B. cinerea is to
change the morphology and the ultrastructure of the mycelium, increase
the permeability of the cell membrane, and cause nucleus and mitochondrial
dysfunction, thus leading to apoptosis. In addition, qualitative and
quantitative structure–activity relationship studies showed
that the inductive and conjugative interactions between compound 4f and the target receptor form an electron transfer process,
thereby achieving an antifungal effect. These results indicated that
compound 4f, which was derived from the natural product
rosin, is a novel potential fungicidal candidate against B. cinerea.
“…Figure 10 shows the σ-profile of polymer. The peaks located between 0 and + 0.01 e Å −2 can be related to the carbon of methyl groups or the non–polar nitrogen groups 40 , 41 . The peaks between 0 and − 0.01 e Å −2 in the σ-profile are related to the hydrogen of CH 3 and CH 2 groups.…”
Section: Resultsmentioning
confidence: 99%
“…The peaks between 0 and − 0.01 e Å −2 in the σ-profile are related to the hydrogen of CH 3 and CH 2 groups. In addition, the peaks between + 0.010 to + 0.020 e Å −2 can be assigned to the O or N atoms 40 , 41 . Figure 10 Sigma profile of the PPGP- g -PCL.…”
The present study aimed to synthesis a proper scaffold consisting of hydroxylated polyphosphazene and polycaprolactone (PCL), focusing on its potential use in tissue engineering applications. The first grafting of PCL to poly(propylene glycol)phosphazene (PPGP) was performed via ROP of ε-caprolactone, whereas PPGP act as a multisite macroinitiator. The prepared poly(propylene glycol phosphazene)-graft-polycaprolactone (PPGP-g-PCL) were evaluated by essential tests, including NMR, FTIR, FESEM-EDS, TGA, DSC and contact angle measurement. The quantum calculations were performed to investigate molecular geometry and its energy, and HOMO and LUMO of PPGP-g-PCL in Materials Studio2017. MD simulations were applied to describe the interaction of the polymer on phospholipid membrane (POPC128b) in Material Studio2017. The C2C12 and L929 cells were used to probe the cell–surface interactions on synthetic polymers surfaces. Cells adhesion and proliferation onto scaffolds were evaluated using FESEM and MTT assay. In vitro analysis indicated enhanced cell adhesion, high proliferation rate, and excellent viability on scaffolds for both cell types. The polymer was further tested via intraperitoneal implantation in mice that showed no evidence of adverse inflammation and necrosis at the site of the scaffold implantation; in return, osteogenesis, new-formed bone and in vivo degradation of the scaffold were observed. Herein, in vitro and in vivo assessments confirm PPGP-g-PCL, as an appropriate scaffold for tissue engineering applications.
“…As a subgroup of porous materials for adsorption of pollutants, ordered mesoporous materials exhibited highly ordered structure, large pore volume, high surface area, and functionalizable surface 21 – 28 . These characteristics make ordered mesoporous materials suitable for a broad range of applications, such as adsorption 29 – 31 . Various silica-based mesoporous materials such as SBA, MCM, KIT, and FDU families have been introduced during the last years.…”
Herein, two novel porous polymer matrix nanocomposites were synthesized and used as adsorbents for heavy metal uptake. Methacrylate-modified large mesoporous silica FDU-12 was incorporated in poly(methyl methacrylate) matrix through an in-situ polymerization approach. For another, amine-modified FDU-12 was composited with Nylon 6,6 via a facile solution blending protocol. Various characterization techniques including small-angle X-ray scattering, FTIR spectroscopy, field emission-scanning electron microscopy, transmission electron microscopy, porosimetry, and thermogravimetric analysis have been applied to investigate the physical and chemical properties of the prepared materials. The adsorption of Pb(II) onto the synthesized nanocomposites was studied in a batch system. After study the effect of solution pH, adsorbent amount, contact time, and initial concentration of metal ion on the adsorption process, kinetic studies were also conducted. For both adsorbents, the Langmuir and pseudo-second-order models were found to be the best fit to predict isotherm and kinetics of adsorption. Based on the Langmuir model, maximum adsorption capacities of 105.3 and 109.9 mg g−1 were obtained for methacrylate-modified FDU-12/poly(methyl methacrylate) and amine-modified FDU-12/Nylon 6,6, respectively.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
