Abstract:Interest in antiviral plant species has grown exponentially and some have been reported to have anti-HIV properties. This research aims to perform the bio-guided phytochemical fractionation by antiretroviral activity of Lafoensia pacari stem barks. This in vitro experimental study involved the preparation of plant material, obtention of ethanolic extract, fractionation, purification, identification and quantification of fractions, acid-base extraction, nuclear magnetic resonance, HIV-1 RT inhibition test and m… Show more
“…EA was found in the rat's brain at a relatively low concentration, indicating that it may be able to cross the blood-brain barrier (BBB). Fonseca et al 57 determined an intermediate BBB penetration value of 0.32 for EA.…”
The aberrant deposition of α–Synuclein (α–Syn) protein into the intracellular neuronal aggregates termed Lewy bodies and Lewy neurites characterize the devastating neurodegenerative condition known as Parkinson’s disease (PD). The disruption...
“…EA was found in the rat's brain at a relatively low concentration, indicating that it may be able to cross the blood-brain barrier (BBB). Fonseca et al 57 determined an intermediate BBB penetration value of 0.32 for EA.…”
The aberrant deposition of α–Synuclein (α–Syn) protein into the intracellular neuronal aggregates termed Lewy bodies and Lewy neurites characterize the devastating neurodegenerative condition known as Parkinson’s disease (PD). The disruption...
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