Molecular Docking and Dynamics Simulation revealed the Potential Inhibitory Activity of Piomozide against Kynurenine metabolism targeting the Kynurenine 3-monooxygenase
Kavya Vinil Kaladan,
Narmadhaa Sivagurunathan,
Rajesh Parsanathan
Abstract:L-tryptophan metabolism depends on the enzyme kynurenine 3-monooxygenase (KMO). Quinolinic acid, kynurenic acid, and other metabolites having consequences for neurology and psychiatry are mostly derived from L-tryptophan. Furthermore, it was shown that hypertension causes an increase in KMO; hence, inhibiting KMO may aid in preventing both hypertension and cardiovascular diseases. In the current investigation, we used in silico techniques to screen for potential KMO inhibitors. SWISS-MODEL was utilized to simu… Show more
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