Molecular docking analysis of marine compounds with voltage gated calcium channel for potential anti-epileptic molecules
Deepak Sheokand,
Annu Grewal,
Pawan Kumar
et al.
Abstract:Epileptic seizures are directly linked with an anomalous influx of extracellular calcium or sodium anions through voltage-gated channels disturb the chemical and electrical gradients, resulting in seizures or jerking moments. Voltage-gated calcium channel (VGCC) subunit α2δ-1 is the binding site for gabapentinoids used to treat epilepsy and neuropathic pain. However, this class of drugs showed severe side effects associated with CNS and respiratory depression. Hence, we screened a total of 2583 phytochemicals … Show more
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