Molecular Diversity in the Abdominal Aortic Aneurysm Phenotype

Successful endovascular treatment of multiple mesenteric arterial aneurysms associated with alpha-1-antitrypsin deficiency

“…The first association between AAT and aneurysms described an "in vitro collagenolysis" as the patho-etiological mechanism for abdominal aortic aneurysmal (AAA) disease. 5 To our knowledge, this is only the second reported case to explore the possible association between mesenteric artery aneurysms and AAT. The presence of multiple small aneurysms accentuated both the rarity and diagnostic challenge associated with our case.…”

Alpha1-antitrypsin deficiency and cardiovascular disease: questions and issues of a debated relation

“…However, provided data results are contradictory. The first hypothesis dates back to 1988, with a work by Tilson and Roberts, 44 but in the 1990s, the interest started to rise.…”

Detection of type III collagen fragments in specimens of abdominal aortic aneurysms

“…1,2 Recent case reports and reviews have noted collagen deficiency in cerebral artery aneurysms and procollagen mutation in familial aortic aneurysms, [3][4][5][6][7] and some investigators have reported that the extracellular matrix of the aorta consisted of collagen and elastin changes during AAA formation. [8][9][10][11][12] Dobrin 21 reported that the mechanical strength of collagen is four orders of magnitude greater than that of elastin and plays a role in the load-bearing capacity of arteries. Sumner and colleagues 22 documented finding decreases in the elastin and collagen contents of aneurysm walls.…”

“…[3][4][5][6][7] Some investigators have also reported a relationship between aortic aneurysms and matrix proteins in aortic walls. [8][9][10][11][12] Reprint requests to: T. Kuga (Received for publication on Dec. 24,1996; accepted on July 8,1997) Collagen is an important extracellular matrix of vessel walls, together with elastin. It has been reported that collagen plays a role in the load-bearing capacity of arteries, and that changes in collagen concentration are tissue-and age-dependent.…”