Molecular diversity in several pyridyl based Cu(ii) complexes: biophysical interaction and redox triggered fluorescence switch

Abstract

A novel approach for detection of intra-cellular Cu+ in E. coli and human blood cells is reported. Studies on several pyridyl based Cu(ii) complexes and interaction of ct DNA with one of them are carried out for plausible application in biology concerning disruption of normal DNA activity.

The first coordination compound of deprotonated 2-bromonicotinic acid: crystal structure of a dinuclear paddle-wheel copper(II) complex

“…These hydrogen-bonded motifs in 1 are quite different from those in the crystal structures of related paddlewheel copper(II) clusters with nicotinate derivatives Adhikari et al, 2016). This difference is not surprising in the case of copper(II) clusters with 2-ethoxynicotinate and 2-(naphthalen-2-ylmethylsulfanyl)nicotinate because the presence of water molecules of crystallization drastically affects the crystal packing Adhikari et al, 2016). The difference in the hydrogen-bonded ring motifs in the case of the copper(II) cluster with 2-methoxynicotinate can be attributed to the different supramolecular arrangement of the cluster molecules, which are connected into a hydrogen-bonded chain, as opposed to a hydrogen- The distinctive hydrogen-bonded ring motifs (represented by dotted lines) found within the layered network of 1, viz.…”

“…This CuÁ Á ÁCu interaction is slightly longer than the sum of the covalent radii of Cu atoms (2.64 Å ; Cordero et al, 2008). The CuÁ Á ÁCu contact length in 1 is also somewhat longer than those in related paddle-wheel copper(II) clusters with nicotinic acid derivatives Adhikari et al, 2016), but almost equal to that seen in the paddle-wheel copper(II) cluster with 2-chloronicotinic acid (Moncol et al, 2007). The Cu-O c and Cu-O w (c = carboxylate, w = water) bond lengths are comparable with literature values (Moncol et al, 2007;Adhikari et al, 2016).…”

“…The water molecules participate in the formation of motifs as both singleand double-proton donors [single in the R 2 2 (8) and R 2 2 (16) motifs and double in the R 4 4 (16) motif], while the carboxylate O and pyridine N atoms participate as single-proton acceptors exclusively. These hydrogen-bonded motifs in 1 are quite different from those in the crystal structures of related paddlewheel copper(II) clusters with nicotinate derivatives Adhikari et al, 2016). This difference is not surprising in the case of copper(II) clusters with 2-ethoxynicotinate and 2-(naphthalen-2-ylmethylsulfanyl)nicotinate because the presence of water molecules of crystallization drastically affects the crystal packing Adhikari et al, 2016).…”

“…In this work, we report the synthesis and characterization of the first metal complex with 2-bromonicotinic acid -a dinuclear paddle-wheel copper(II) cluster, [Cu(H 2 O)(2-Brnic) 2 ] 2 (1). Although similar dinuclear paddle-wheel copper(II) carboxylates with coordinated water molecules in the axial positions are well-established and have been extensively studied, there are only a few examples of such compounds that are analogous to 1, containing nicotinate derivatives [2-chloronicotinate, 2-methoxynicotinate, 2-ethoxynicotinate and 2-(naphthalen-2-ylmethylsulfanyl)nicotinate] as carboxylates (Moncol et al, 2007;Adhikari et al, 2016).…”

Structure and Magnetic Properties of a 2D Paddle‐wheel Dinuclear[Cu2] Cluster‐based Polymer with 1,1‐Cyclohexanediacetate Ligand

“…The four syn ‐ syn carboxylate groups come from four CHDA 2– ligands (Figure b), from which the oxygen atoms define an equatorial coordinated plane of two centro‐symmetric Cu II ions with Cu–O distances ranging from 1.9421(15) to 2.0032(14) Å. The terminal water molecule together with the other central Cu II ion occupy the axial octahedral positions with a obviously longer Cu–O distance of 2.1434(17) Å, which may be due to the Jahn‐Teller effect , …”