Molecular diversity between two cohorts of six Spanish riding-horse breeds: Impact of selection in Crossbred vs Purebred populations

Negro, Sara; Solé, Marina; Pelayo, R.; Gómez, María Dolores; Azor, P. J.; Valera, M.

doi:10.1016/j.livsci.2016.09.013

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…Additionally, H o and H e values were also high in all the subpopulations except for grey horses, suggesting that their genetic background was wider but more concentrated in some particular lineages, thus leading to an increased genetic drift. These results are among the highest currently reported in this species in studies performed using similar markers, ranging between 0.40 and 0.79 (Achmann et al., ; Berber et al., ; Leroy et al., ; Plante et al., ; Prystupa, Juras, Cothran, Buchanan, & Plante, ); furthermore, they validate our preliminary study using an 80 times smaller dataset (2,808 individuals; Negro et al., ).…”

Section: Discussionsupporting

confidence: 86%

“…This hypothesis could partially explain our results, consid- Note. μ (mutation rate per population); the number of effective migrants per generation (N m = (1 − F ST )/4F ST ); (δμ) 2 = average square distance allows to calculate divergence times with the formula: [(δμ) 2 /2β]g. furthermore, they validate our preliminary study using an 80 times smaller dataset (2,808 individuals; Negro et al, 2016).…”

Section: Discussionsupporting

confidence: 79%

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Morphological and genetic diversity of Pura Raza Español horse with regard to the coat colour

Sánchez-Guerrero

Negro-Rama

Demyda-Peyrás

et al. 2018

Animal Science Journal

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Gene mutations influencing melanocytes also impact on physiological and behavioural functions. In this study, we investigated their association with four different coat colours in the Pura Raza Español (PRE) horse using morphological traits and molecular datasets. Four different subpopulations were identified according to individual coat colour: grey, bay, chestnut and black. Coat colour significantly associated with morphological measurements. Observed and expected heterozygosity values were low in grey compared with the other three subpopulations, suggesting the presence of unique ancestral alleles probably arisen by genetic drift and selection mechanism effects. Nei's distance demonstrated a clear division among subpopulations, the grey being the most divergent group. Gene flow estimates were similar, showing the lowest values in grey. Divergence times among subpopulations assessed with the average square distance suggested that grey was the original PRE population which diverged from bay, chestnut and black. Our results also demonstrated a clear morphological differentiation according to coat colour. The close genetic structure of bay and chestnut PRE subpopulations and the clear differences in most morphological traits of grey and chestnut PRE mares would suggest the pleiotropic effect of genomic regions determining coat colour in horses. However, further analysis including genomic information would be necessary to elucidate the mechanisms involved.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 79%

Morphological and genetic diversity of Pura Raza Español horse with regard to the coat colour

Sánchez-Guerrero

Negro-Rama

Demyda-Peyrás

et al. 2018

Animal Science Journal

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“…Lower heritability values have also been reported by Perdomo-González et al. (2022) for HatW, LHA, DSD, AS, TP, HSD, and AC (0.19, 0.10, 0.21, 0.12, 0.41, and 0.21, respectively) in the current population of Pura Raza Menorquina horse, another autochthonous Spanish horse breed, and a breed which is genetically very close to the PRE horse ( Negro et al., 2016 ).…”

Section: Discussionmentioning

confidence: 52%

Designing an early selection morphological traits index for reproductive efficiency in Pura Raza Española mares

Perdomo-González,

Sánchez-Guerrero,

Bartolomé

et al. 2023

Journal of Animal Science

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The low rate of reproductive efficiency in horses may be linked to the equine industry’s practice of maintaining breeding stock that stands out for its athletic or morphological performance but exhibits poor reproductive efficiency. In this study, the age at first foaling, age at last foaling, interval between first and second foaling, average interval between foaling, foaling number and reproductive efficiency, and their relationship with the morphological records in 19,758 Pura Raza Española (PRE) mares were analyzed. After a Partial Least Squares analysis height at withers, lateral hock angle, dorsal-sternal diameter, perimeter of anterior cannon bone, angle of shoulder, thoracic perimeter, hip-stifle distance, and angle of croup were the most important traits related with reproductive traits in PRE mares. A multivariate animal model with both morphological and reproductive traits was applied, including age, geographical area, coat color and average stud size in the decade of the mare’s first foaling. The results indicate that reproductive selection is feasible, and is enhanced by the use of morphological traits, given the moderate to high magnitudes of heritability values in both types of traits, which oscillated between 0.1 (interval between first and second foaling) and 0.95 (height at withers). The resulting genetic parameters were used to develop a series of selection indexes based on morphological or morphological and reproductive combination traits to improve reproductive efficiency traits in PRE mares and thus compute the expected genetic response (EGR) for the different strategies. The increase in EGR, when comparing EGR using only reproductive traits as selection criteria versus using a combined index of both morphological and reproductive traits, oscillated between 4.0% for the age at first foaling to 46.8% for the interval between first and second foaling. In addition, two precocity indexes showed positive EGR when the age at last foaling and the interval between first and second foaling, both with and without morphological traits, were used as selection criteria. Therefore, this analysis reveals that the preselection of reproductive traits based on morphological traits is possible in PRE mares. Ultimately, this knowledge will help breeders achieve genetic progress in reproductive traits, leading to healthier and more successful breeding outcomes in horses.

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“…The Pura Raza Española (PRE) horse is an autochthonous Spanish horse with more than 260,000 active animals distributed in 65 countries over the five continents, particularly in Spain, Mexico, the U.S.A., France, and Costa Rica, among others. This breed has a large pedigree, with a stud book created in 1912 with a high completeness of the pedigree (Perdomo‐González et al, 2020) and over 40 years of proven parental information by serum biochemical polymorphism and DNA microsatellites (de Andres Cara & Kaminsky, 1985; Kaminski & de Andres Cara, 1986; Negro et al, 2016), which make it a perfect population for analysing the quantitative effect of imprinted loci.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of parent‐of‐origin effect in reproductive and morphological selection criteria in the Pura Raza Española horse

Perdomo-González

Varona

Molina

et al. 2023

J Animal Breeding Genetics

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It is generally assumed that parents make a genetically equal contribution to their offspring, but this assumption might not always hold. This is because the expression of a gene can be blocked by methylation during gametogenesis, and the degree of methylation can depend on the origin of the parental gene (imprinting) or by preferential management associated with genetic merit. The first consequences of this for quantitative genetics is that the mean phenotypes of reciprocal heterozygotes need no longer be the same, as would be expected according to Mendelian heritage. We analysed three mare reproductive traits (reproductive efficiency, age at first foaling and foaling number) and three morphological traits (height at withers, thoracic circumference, and scapula‐ischial length) in the Pura Raza Española (PRE) horse population, which possesses a deep and reliable pedigree, making it a perfect breed for analysing the quantitative effect of parent‐of‐origin. The number of animals analysed ranged from 44,038 to 144,191, all of them with both parents known. The model comparison between a model without parent‐of‐origin effects and three different models with parent‐of‐origin effects revealed that both maternal and paternal gametic effects influence all the analysed traits. The maternal gametic effect had a higher influence on most traits, accounting for between 3% and 11% of the total phenotypic variance, while the paternal gametic effect accounted for a higher proportion of variance in one trait, age at first foaling (4%). As expected, the Pearson's correlations between additive breeding values of models that consider parent‐of‐origin and that do not consider parent‐of‐origin were very high; however, the percentage of coincident animals slightly decreases when comparing animals with the highest estimated breeding values. Ultimately, this work demonstrates that parent‐of‐origin effects exist in horse gene transmission from a quantitative point of view. Additionally, including an estimate of the parent‐of‐origin effect within the PRE horse breeding program could be a great tool for a better parent's selection and that could be of interest for breeders, as this value will determine whether the animals acquire genetic categories and are much more highly valued.

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Molecular diversity between two cohorts of six Spanish riding-horse breeds: Impact of selection in Crossbred vs Purebred populations

Cited by 4 publications

References 18 publications

Morphological and genetic diversity of Pura Raza Español horse with regard to the coat colour

Morphological and genetic diversity of Pura Raza Español horse with regard to the coat colour

Designing an early selection morphological traits index for reproductive efficiency in Pura Raza Española mares

Quantitative analysis of parent‐of‐origin effect in reproductive and morphological selection criteria in the Pura Raza Española horse

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