Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning

Kühn, Katja; Edamura, Kazusa; Bhatia, N.; Cheng, Irene H.; Clark, Shayla; Haynes, C.V.; Heffner, Danielle L.; Kabir, Farah; Velasquez, Johana Tello; Spano, Anthony; Deppmann, Christopher D.; Keeler, Austin B.

doi:10.1016/j.mcn.2020.103467

Cited by 7 publications

(4 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the absence of enzymatic activity in its cytoplasmic domain, p75NTR does not signal via conventional channels. Therefore, interactors of the intracellular domain or interacting proteins that are attracted to or connected with the receptor contribute to the signaling of the p75NTR including apoptosis [193,194], p53 activation via the Jun kinase signaling cascade, and activation of NF-κB for neuronal survival [195] and axonal development [196]. p75NTR activation is also influenced by interactions with other receptors and transmembrane proteins [197,198].…”

Section: The P75ntr-mediated Signaling Pathwaymentioning

confidence: 99%

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

et al. 2023

View full text Add to dashboard Cite

The Zingiberaceae family possess various phenolic compounds that have significant systemic bioactivities in the brain, including in age-related neurodegenerative diseases. Neurotrophins are growth factors that protect neurons from oxidative stress, and dysregulation of the neurotrophic system may result in neurocognitive disease. Phenolic compounds from the Zingiberaceae family have been used in traditional and complementary medicine (TCM) to improve cognitive functions. These compounds may affect the expression of neurotrophic agents, but their underlying molecular mechanisms require further investigation. Therefore, the goal of this review is to determine the expression and functional roles of phenolic compounds from the Zingiberaceae family in brain disorders and age-related neurodegenerative disorders. While previous studies have proposed various mechanisms for the neuroprotective activity of these compounds, their precise mechanism of action remains complex and poorly understood. Despite some promising findings, there are still shortcomings in the therapeutic use of these herbs, and current interventions involving the Zingiberaceae family appear to be clinically insufficient. This article aims to summarize recent discoveries of phenolic compounds from several Zingiberaceae family members and their use as neuroprotectants and provide the first review of evidence-linked neuroprotective activity of bioactive ingredients from prominent members of the Zingiberaceae family.

show abstract

Section: The P75ntr-mediated Signaling Pathwaymentioning

confidence: 99%

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Recent work by Kuhn et al. established that TNFα, in collaboration with TNFR1, TNFR2, and p75NTR, induces signals that are indispensable for neural development and that disturbances to TNFR family signaling result in unhealthy axonal development ( 136 ).…”

Section: Mechanisms Related To Inflammation In Rpmentioning

confidence: 99%

Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system

Ling

Hou²,

Yan³

2022

Front. Immunol.

View full text Add to dashboard Cite

Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and lacks effective treatment strategies. Although mutations are the primary cause of RP, research over the past decades has shown that neuroinflammation is an important cause of RP progression. Due to the abnormal activation of immunity, continuous sterile inflammation results in neuron loss and structural destruction. Therapies targeting inflammation have shown their potential to attenuate photoreceptor degeneration in preclinical models. Regardless of variations in genetic background, inflammatory modulation is emerging as an important role in the treatment of RP. We summarize the evidence for the role of inflammation in RP and mention therapeutic strategies where available, focusing on the modulation of innate immune signals, including TNFα signaling, TLR signaling, NLRP3 inflammasome activation, chemokine signaling and JAK/STAT signaling. In addition, we describe epigenetic regulation, the gut microbiome and herbal agents as prospective treatment strategies for RP in recent advances.

show abstract

“… 2 Noteworthy, p75 NTR is a member of the superfamily of tumor necrosis factor receptors. 3 It consists of 3 domains, intracellular, transmembrane and extracellular. 2 The tendency of p75 NTR is toward dimerization rather than trimerization, owing to the activation of the tyrosine kinase co-receptor.…”

Section: Introductionmentioning

confidence: 99%

The functional and molecular roles of p75 neurotrophin receptor (p75^NTR) in epilepsy

Turkistani,

Al-kuraishy,

Al-Gareeb

et al. 2024

J Cent Nerv Syst Dis

View full text Add to dashboard Cite

Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interplay between the reduction of inhibitory gamma-aminobutyric acid (GABA) and the enhancement of excitatory glutamate. Pro-BDNF/p75NTR expression is augmented in both glial cells and neurons following epileptic seizures and status epileptics (SE). Over-expression of p75NTR is linked with the pathogenesis of epilepsy, and augmentation of pro-BDNF/p75NTR is implicated in the pathogenesis of epilepsy. However, the precise mechanistic function of p75NTR in epilepsy has not been completely elucidated. Therefore, this review aimed to revise the mechanistic pathway of p75NTR in epilepsy.

show abstract

Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning

Cited by 7 publications

References 63 publications

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system

The functional and molecular roles of p75 neurotrophin receptor (p75^NTR) in epilepsy

Contact Info

Product

Resources

About

Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning

Cited by 7 publications

References 63 publications

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system

The functional and molecular roles of p75 neurotrophin receptor (p75NTR) in epilepsy

Contact Info

Product

Resources

About

The functional and molecular roles of p75 neurotrophin receptor (p75^NTR) in epilepsy