2019
DOI: 10.1038/s41576-019-0125-3
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Molecular digital data storage using DNA

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Cited by 395 publications
(415 citation statements)
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“…In the era of Big Data, molecular DNA has become an increasingly attractive medium for the storage and archiving of digital data [1][2][3][4][5][6] . This is primarily attributed to its ultra-high storage density, which is currently estimated to be in the hundreds of petabytes per gram DNA 7 .…”
Section: Spontaneous Quenching Of Reactions By the Diffusion Of Excesmentioning
confidence: 99%
See 1 more Smart Citation
“…In the era of Big Data, molecular DNA has become an increasingly attractive medium for the storage and archiving of digital data [1][2][3][4][5][6] . This is primarily attributed to its ultra-high storage density, which is currently estimated to be in the hundreds of petabytes per gram DNA 7 .…”
Section: Spontaneous Quenching Of Reactions By the Diffusion Of Excesmentioning
confidence: 99%
“…Many time-consuming steps of expensive and harsh reactions with the accumulation of toxic by-products greatly limit chemical synthesis as the demand for longer and larger quantities of DNA oligonucleotides increases 11 . 3 Recently, the use of terminal deoxynucleotidyl transferase (TdT), a template-independent polymerase, to synthesize DNA oligonucleotides was shown to be a promising alternative to chemical synthesis [12][13][14] . Because synthesis reactions are performed under aqueous conditions, many limiting aspects of the phosphoramidite chemistry can be circumvented or improved upon.…”
Section: Spontaneous Quenching Of Reactions By the Diffusion Of Excesmentioning
confidence: 99%
“…Most efforts to use DNA as a data storage medium have involved inserting data either into "naked," molecular DNA or into DNA contained in laboratory strains of E. coli. Between 1999 and 2012, all attempts at recording digital information into DNA were recorded in vivo (27).…”
Section: -D Encoded Dnamentioning
confidence: 99%
“…DNA-based information storage continues to gain momentum with the emergence of highthroughput DNA sequencing (sequencing-by-synthesis) and synthesis (array-based synthesis); these technologies enable vast amounts of text and visual (1)(2)(3) information to be encoded, stored, and decoded. DNA data storage offers unique advantages over mainstream storage methods like magnetic tape and hard disk drives, including higher physical density and longer retention lifetimes (4). This is particularly useful for archival storage, where current access speeds and read/write costs are not an issue.…”
Section: Introductionmentioning
confidence: 99%