Molecular Diagnostics in Low-Grade Gastric Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type After Helicobacter pylori Eradication Therapy

Alpen, Birgit; Thiede, Christian; Wündisch, Thomas; Bayerdörffer, Ekkehard; Stolte, Manfred; Neubauer, Andreas

doi:10.3816/clm.2001.n.015

Cited by 9 publications

(3 citation statements)

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“…An important aim of the ongoing lymphoma trials is to find out the clinical relevance of these monoclonal B-cells. The latest data from our study show a trend that monoclonality might be associated with a higher risk for relapse (Alpen et al, 2000). In summary, molecular analysis of the rearranged IgH can be used to "fingerprint" the lymphoma and thus identify minimal disease and look for clonal evolution within the B-cell clone.…”

Section: Clonality Analysis Of B-cellsmentioning

confidence: 64%

Are lymphocytic monoclonality and immunoglobulin heavy chain (IgH) rearrangement premalignant conditions in chronic gastritis?

Wündisch

Thiede

Alpen

et al. 2001

Microscopy Res & Technique

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Normal gastric mucosa is devoid of lymphoid cells. Any increase of lymphocytes suggests chronic inflammation. Infection with Helicobacter pylori (Hp) is the major cause for nonautoimmune chronic gastritis and induces a mixed cellular response resulting in an acquired lymphoid tissue, or MALT (mucosa-associated lymphoid tissue). Hp has also been implicated in the genesis of gastric MALT-lymphoma. Polymerase chain reaction-based assays to detect the expansion of monoclonal B-cells have also been used to corroborate the diagnosis. In a considerable number of cases monoclonal B-cells remain detectable in follow-up biopsies, with the lymphoma being in complete histological remission. The clinical relevance of this finding is not clear yet. However, there also exist different reports that monoclonal B-cells can be found in gastric biopsies of patients with neither a histological sign nor a present or past history of lymphoma. In the light of these findings we address the question whether B-cell monoclonality can be seen as a premalignant condition in chronic gastritis and conclude that as of now the relevance of the finding of B-cell monoclonality remains unclear. As of now the only and gold standard for the diagnosis of gastric MALT-lymphoma is histopathology.

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Section: Clonality Analysis Of B-cellsmentioning

confidence: 64%

Are lymphocytic monoclonality and immunoglobulin heavy chain (IgH) rearrangement premalignant conditions in chronic gastritis?

Wündisch

Thiede

Alpen

et al. 2001

Microscopy Res & Technique

Self Cite

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“…In the H pylori infected stomach, it is well known that gastric mucosa other than MALT lymphoma lesions, may have B cell monoclonality. Even after H pylori eradication therapy, it has been reported that about 50% of patients had B cell monoclonality in their gastric mucosa [26,27] . It is not certain that this B cell monoclonality reflects the presence of a remnant or pre-malignant lesion.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features of surgically resected primary gastric lymphoma

Kong¹,

Kim²,

Park³

et al. 2004

WJG

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AIM:To analyze the clinicopathologic characteristics of surgically resected gastric lymphoma patients. METHODS:We retrospectively analyzed 57 surgically resected gastric lymphoma patients, dividing them into 2 subgroups: Low grade MALToma (the LG group), High grade MALToma and Diffuse large B cell lymphoma (the HG group). RESULTS:The numbers of patients were: 20 in the LG group, 37 in the HG group. The diagnostic rate of gastroscopy was 34.8% at primary diagnosis and 50% including differential diagnoses. The positive rates of H pylori were similar between the 2 groups (68% vs 77%). Multiple lesions were found in 19.3%. The proportion of mucosal and submucosal lesions was 80.0%(16/20) in the LG group, and 24.3%(9/37) in the HG group (P<0.001). Lymph node invasion rates were 10.5%(2/19) in the LG group and 44.1%(15/34) in the HG group (P=0.031). The numbers of recurred patients were none in the LG group, and 8 in the HG group. By univariant analysis, group (P=0.024) and TNM stage (stage I, II vs stages III, IV, P=0.002) were found to be the significant risk factors. There was a tendency of higher recurrence rate in the subtotal gastrectomy group than in the total gastrectomy group (P=0.50). CONCLUSION:The HG groups had a more advanced stage and a higher recurrence rate than the LG group. Although there was no difference between subtotal and total gastrectomies, more careful assessments of multiplicities and radical resections with lymph node dissections seem to be needed because of multiplicity and LN invasion even in LG group.Kong SH, Kim MA, Park DJ, Lee HJ, Lee HS, Kim CW, Yang HK, Heo DS, Lee KU, Choe KJ. Clinicopathologic features of surgically resected primary gastric lymphoma.

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“…14 In the post-eradication follow-up setting, it has been demonstrated that many of the residual basal lymphoid aggregates (probable minimal residual disease in GELA system) harbour small residual clonal lymphoma cell populations. 37 In addition, clonal populations reappear and disappear in follow-up biopsies over time and without therapeutic intervention 38 indicating that the detection of a clonal population in isolation does not predict for relapsed disease, which should only be considered if the morphological features are those of overt MALT lymphoma (Wotherspoon score 4-5).…”

Section: Extranodal Marginal Zone Lymphoma Of Mucosa-associated Lymphmentioning

confidence: 99%

Extranodal and splenic small B-cell lymphoma

Wotherspoon

2013

Modern Pathology

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Molecular Diagnostics in Low-Grade Gastric Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type After Helicobacter pylori Eradication Therapy

Cited by 9 publications

References 54 publications

Are lymphocytic monoclonality and immunoglobulin heavy chain (IgH) rearrangement premalignant conditions in chronic gastritis?

Are lymphocytic monoclonality and immunoglobulin heavy chain (IgH) rearrangement premalignant conditions in chronic gastritis?

Clinicopathologic features of surgically resected primary gastric lymphoma

Extranodal and splenic small B-cell lymphoma

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