Molecular Diagnosis and Epidemiology of African Swine Fever Outbreaks in Tanzania

Wambura, Philemon N.; Masambu, Joseph; Msami, H.M.

doi:10.1007/s11259-006-3280-x

Cited by 27 publications

(48 citation statements)

References 4 publications

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“…Genomic homogeneity among African ASFV isolates associated with disease outbreaks in domestic swine relative to isolates isolated from ticks has also been noted (Dixon and Wilkinson 1988;Sumption et al 1990). Subsequent molecular phylogenetic studies utilizing part of the p72 gene support some of these findings, including relative homogeneity among West African, European, and American isolates, homogeneity among certain African lineages associated with outbreaks in domestic swine, and relative heterogeneity among isolates from southern and East Africa Lubisi et al 2003;Wambura et al 2006).…”

Section: The Asfv Genomementioning

confidence: 92%

African Swine Fever Virus

Tulman

Delhon

et al. 2009

Current Topics in Microbiology and Immunology

132

117

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African swine fever virus (ASFV) is a large, intracytoplasmicallyreplicating DNA arbovirus and the sole member of the family Asfarviridae . It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus-host interactions, and viral virulence. Increasingly apparent is the complexity with which ASFV replicates and interacts with the host cell during infection. ASFV encodes novel genes

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Section: The Asfv Genomementioning

confidence: 92%

African Swine Fever Virus

Tulman

Delhon

et al. 2009

Current Topics in Microbiology and Immunology

132

117

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“…As of July 2012, ASF was reported again in the Mbeya and Iringa regions, from which it had been eliminated. This unique ASF outbreak in Tanzania persistently circulated for more than a year; previous outbreaks have been sporadic and resolved after shorter durations ( 8 – 10 ). …”

mentioning

confidence: 97%

“…Spread of ASFV beyond traditional geographic boundaries occurred with incursion of p72 genotype II into the Republic of Georgia and its subsequent spread into Armenia, Azerbaijan, and Russia ( 4 , 5 ) and incursion of genotype IX into western Africa ( 6 ). ASFV circulating in Tanzania has p72 genotypes X, XV, and XVI ( 7 – 10 ). We describe incursion and persistent circulation in Tanzania of a highly virulent p72 genotype II ASFV that is identical to the Georgia 2007/1 isolate in the 3′-end of the B646L gene.…”

mentioning

confidence: 99%

African Swine Fever Virus, Tanzania, 2010–2012

Misinzo¹,

Kasanga²,

Mpelumbe-Ngeleja³

et al. 2012

Emerg. Infect. Dis.

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“…Most of a cluster of outbreaks that occurred in Northern Tanzania in 2013 were reported to have resulted from feeding catering swill containing infected pork leftovers and movement of infected pigs, but the fact that the outbreaks started close to conservation areas suggested that the initial outbreak may have resulted from warthog contact (Misinzo et al., ). The fact that in several countries wild pigs, in particular warthogs, are largely if not entirely restricted to conservation areas has been cited as a factor that reduces their likely role of the epidemiology of ASF in domestic pigs, which in some cases has been confirmed by molecular studies of viruses (Haresnape & Mamu, ; Wambura, Masambu, & Msami, ). However, it is probable that free‐range pigs farming in close proximity to conservation areas poses a higher risk of infection with African swine fever virus (ASFV; Katale, Fyumagwa, Mdaki, & Hoare, ; Kukielka et al., ).…”

Section: Outbreaks Related To Wild African Suidsmentioning

confidence: 99%

Epidemiology of African swine fever in Africa today: Sylvatic cycle versus socio‐economic imperatives

Penrith

Bastos

Etter

et al. 2019

Transbound Emerg Dis

101

119

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African swine fever (ASF) is believed to have evolved in eastern and southern Africa in a sylvatic cycle between common warthogs (Phacochoerus africanus) and argasid ticks of the Ornithodoros moubata complex that live in their burrows. The involvement of warthogs and possibly other wild suids in the maintenance of ASF virus means that the infection cannot be eradicated from Africa, but only prevented and controlled in domestic pig populations. Historically, outbreaks of ASF in domestic pigs in Africa were almost invariably linked to the presence of warthogs, but subsequent investigations of the disease in pigs revealed the presence of another cycle involving domestic pigs and ticks, with a third cycle becoming apparent when the disease expanded into West Africa where the sylvatic cycle is not present. The increase in ASF outbreaks that has accompanied the exponential growth of the African pig population over the last three decades has heralded a shift in the epidemiology of ASF in Africa, and the growing importance of the pig husbandry and trade in the maintenance and spread of ASF. This review, which focuses on the ASF situation between 1989 and 2017, suggests a minor role for wild suids compared with the domestic cycle, driven by socio‐economic factors that determine the ability of producers to implement the control measures needed for better management of ASF in Africa.

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Molecular Diagnosis and Epidemiology of African Swine Fever Outbreaks in Tanzania

Cited by 27 publications

References 4 publications

African Swine Fever Virus

African Swine Fever Virus

African Swine Fever Virus, Tanzania, 2010–2012

Epidemiology of African swine fever in Africa today: Sylvatic cycle versus socio‐economic imperatives

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