Molecular determinants of sterile inflammation

Kono, Hajime; Onda, Akiko; Yanagida, Tamiko

doi:10.1016/j.coi.2013.12.004

Cited by 72 publications

(63 citation statements)

References 131 publications

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“…Later, Matzinger proposed the existence of host molecules (DAMPs) that are released or secreted in response to tissue damage and can initiate and perpetuate an immune response (23,24). Subsequently, it was proven that one of the functions of PRRs is the sensing of tissue damage, and many DAMPs had been identified currently (1)(2)(3)19). Recently, Medzhitov et al proposed that allergic reactions are a component of the host defense system against noninfectious noxious environmental factors, including venoms, noxious xenobiotics, and irritants that can induce tissue damage (25).…”

Section: Discussionmentioning

confidence: 99%

“…There is growing evidence that the PRRs of the innate immune system play a key role in the induction of rapid inflammation in response to infection and tissue trauma (3,19,20). The description of PRRs as a limited number of evolutionarily conserved receptors that recognize molecular patterns of infectious agents, the so-called PAMPs, was first developed by Janeway (21,22).…”

Section: Discussionmentioning

confidence: 99%

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Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

Kostarnoy

Gancheva

Lepenies

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation; however, the underlying molecular mechanisms are not yet completely understood. Here, we show that cholesterol sulfate, a molecule present in relatively high concentrations in the epithelial layer of barrier tissues, is selectively recognized by Mincle (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in response to skin damage. Mincle activation by cholesterol sulfate causes the secretion of a range of proinflammatory mediators, and s.c. injection of cholesterol sulfate results in a Mincle-mediated induction of a severe local inflammatory response. In addition, our study reveals a role of Mincle as a driving component in the pathogenesis of allergic skin inflammation. In a well-established model of allergic contact dermatitis, the absence of Mincle leads to a significant suppression of the magnitude of the skin inflammatory response as assessed by changes in ear thickness, myeloid cell infiltration, and cytokine and chemokine secretion. Taken together, our results provide a deeper understanding of the fundamental mechanisms underlying sterile inflammation.innate immunity | sterile inflammation | allergy | Mincle | cholesterol sulfate

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

Kostarnoy

Gancheva

Lepenies

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…This tissue damage causes cell death and chronic inflammation, so-called "sterile inflammation" (indicating absence of detectable pathogens) or inflamm-aging [42,43] through the release of the so-called senescence associated secretory phenotype (SASP) [44][45][46]. SASP is represented by a myriad of factors collectively called damageassociated molecular patterns (DAMPs) [40,[44][45][46][47][48]. This condition is supported by "danger theory" introduced by Polly Matzinger [49], based on the concept that the primary function of the immune system stays in detecting and protecting the host against danger.…”

Section: Structural and Functional Features Of The Aorta In Physiologmentioning

confidence: 99%

“…This condition is supported by "danger theory" introduced by Polly Matzinger [49], based on the concept that the primary function of the immune system stays in detecting and protecting the host against danger. Thus, the initiation of the immune response is not represented by foreign or stranger microbes (non-self), but by alarm signals generated by injured or damaged cells and tissues, collectively referred to as DAMPs [46][47][48].…”

Section: Structural and Functional Features Of The Aorta In Physiologmentioning

confidence: 99%

Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”

Balistreri

Ruvolo

Lio

et al. 2017

Journal of Molecular and Cellular Cardiology

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“…Contrary to microbial infection, where the released bacterial products trigger an inflammatory response, the dying cells release intra and extracellular matrix molecules (damaged-associated molecular patterns, DAMPs) after mechanical injury (Rock et al, 2010, Kono et al, 2014. The immune cells identify these non-pathogenic DAMPs through specialised pattern recognition receptors (PRRs), the toll-like receptors (TLR 1-10) (Kannaki et al, 2011, Shen et al, 2013.…”

Section: Effects Of Endometrial Sampling On Uterine Healthmentioning

confidence: 99%

63 Effect of Endometrial Biopsy on Uterine Health of Tropically Adapted Beef Cattle

Ramirez-Garzon

Satake

Lyons

et al. 2017

Reprod. Fertil. Dev.

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In cattle, early embryonic loss during the first two to three weeks after fertilisation is recognised as the major cause of reproductive failure, with consequent significant impacts on business performance of beef and dairy farms. Inadequate endometrial receptivity is considered an important cause of early embryonic mortality in cattle. A pilot experiment was conducted to compare the outcome of performing different endometrial sampling procedures in tropically adapted (Bos indicus x Bos taurus) heifers, and to select the most suitable method to collect samples for investigation of endometrial gene expression. Endometrial biopsy (EB) using a biopsy device with a diameter similar to an artificial insemination gun (10366L Karl Storz®, Germany) was found to be the most reliable method of collecting endometrial samples in these heifers, with the samples recovered yielding a mean concentration of RNA of 72.9 ±39.3 ng/µl and mean RNA integrity number (RIN) of 7.3 ±1.1.To assess the likely safety of conducting EB in cattle a systematic review of published information assessing the impact of EB on subsequent pregnancy rates was conducted. Using the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) protocol, online searches identified 1164 possible studies. After applying the exclusion criteria, six studies allowed the comparison of pregnancy rates between sampled (n= 1,208) and non-sampled cows (n=2,393). The results showed that EB can be performed before breeding without adversely affecting the likelihood of cows becoming pregnant.A major objective of the research was to determine whether EB and evaluation of endometrial gene expression could be used to identify tropically adapted embryo transfer (ET) recipients more likely to become pregnant. Three potential EB scenarios were investigated, 1) EB on Day 7 of the oestrous cycle prior to the cycle when ET would be performed, 2) EB on Day 4 of the oestrous cycle in which ET would be performed i.e. EB 3 days before ET, and 3) EB on the same day when ET would be performed.The first study assessed the morphological and inflammatory changes induced by endometrial biopsy. Pre-synchronised heifers underwent EB from the horn ipsilateral to the corpus luteum (CL) either at Day 7 of the previous cycle (Group 1 n=10) followed by administration of a luteolytic dose of prostaglandin F2α or at Day 4 (Group 2, n=7) of the present cycle. All heifers were slaughtered on Day 7 of the present cycle. The site of EB was visually evident in 40% (4/10) of Group 1 and 42% (3/7) of Group 2 heifers. Histological assessment revealed no evidence of changes indicative of endometritis in either the biopsied or non-biopsied horns in both groups. The histological iii changes observed included mild mononuclear infiltration of the epithelium and mild vascular changes associated with haemorrhage and congestion.Initial investigation of the endometrial expression of the pro-inflammatory cytokine IL1β and wound healing cytokine TGFβ genes found no significant difference betwe...

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Molecular determinants of sterile inflammation

Cited by 72 publications

References 131 publications

Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”

63 Effect of Endometrial Biopsy on Uterine Health of Tropically Adapted Beef Cattle

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