Molecular detection of tick-borne pathogens harbored by ticks collected from livestock in the Xinjiang Uygur Autonomous Region, China

Li, Yongchang; Wen, Xiuxiu; Li, Min; Moumouni, Paul Franck Adjou; Galon, Eloiza May; Guo, Qingyong; Rizk, Mohamed Abdo; Liu, Mingming; Li, Jixu; Ji, Shengwei; Tumwebaze, Maria Agnes; Byamukama, Benedicto; Chahan, Bayin; Xuan, Xuenan

doi:10.1016/j.ttbdis.2020.101478

Cited by 26 publications

(28 citation statements)

References 47 publications

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“…The present study reports for the first time the presence of C. burnetii DNA in camels in UAE. The htpB gene has previously been used for the detection of Coxiella organisms as well as for phylogenetic analyses [49,50]. HtpB sequences obtained in this study showed a high genetic relatedness with the ones of C. burnetii strains previously documented in Europe (Slovakia, Belarus Italy), Africa (Nigeria, Tunisia), and Asia (China), as supported by high bootstrap values.…”

Section: Discussionsupporting

confidence: 76%

Molecular Investigation on Tick-Borne Hemoparasites and Coxiella burnetii in Dromedary Camels (Camelusdromedarius) in Al Dhafra Region of Abu Dhabi, UAE

Tigani-Asil

Blanda

Abdelwahab

et al. 2021

Animals

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Camels represent an important resource for inhabitants of the most arid regions of the world and their survival is mainly related to environment conditions including the risk of parasitic diseases, which may represent a significant cause of losses in livestock production of these areas. Camels may be parasitized by several hematophagous arthropods, which can be vectors of several diseases including zoonosis. This study aimed to investigate in dromedary camels and their ticks the importance of tick-borne hemoparasites that might be responsible for a recent and obscure morbidity of camels in Al Dhafra region of Abu Dhabi, UAE. Blood samples and ticks from 93 naturally infected camels belonging to 36 herds, affected by variable acute clinical syndromes lasting from 3 to 5 days, were analyzed through molecular techniques for specific DNA presence of different blood pathogens: Anaplasmamarginale/Anaplasmaovis, Anaplasma phagocytophilum, Coxiella burnetii,Babesia spp., and Theileria spp. DNA. All the 72 ticks collected belonged to the Hyalomma dromedarii species and were negative for blood pathogens. n = 15 camels (16.1%) were found positive to the following tick-borne hemoparasites: A. phagocytophilum 11 (11.8%), Coxiella burnetii 3 (3.2%), and Babesia/Theileria spp. 2 (2.1%). One singular camel showed coinfection of C. burnetii and A. phagocytophiulm. Genetic profile of C. burnetii showed a high phylogenetic relatedness to European, Asian and African C. burnetii strains. This is the first laboratory investigation on tick-borne pathogens in camels in UAE, and the first report of A. phagocytophilum and C. burnetii. Moreover, since the detected pathogens are recognized pathogens for humans, this study highlights the zoonotic risk for humans working in camel husbandry.

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Section: Discussionsupporting

confidence: 76%

Molecular Investigation on Tick-Borne Hemoparasites and Coxiella burnetii in Dromedary Camels (Camelusdromedarius) in Al Dhafra Region of Abu Dhabi, UAE

Tigani-Asil

Blanda

Abdelwahab

et al. 2021

Animals

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“…In the Xinjiang Uygur Autonomous Region, 5822 ticks collected from cattle, goats, sheep, camels and horses were tested for tick-borne pathogens. These ticks consist of 12 species, but the results show that only A. ovis infections exist among these ticks and no other types of Anaplasma infections have been detected [35]. However, up to now, 50 species of ticks have been found in Xinjiang, which is a province with developed animal husbandry in China.…”

Section: Discussionmentioning

confidence: 95%

First Molecular Detection of Anaplasma Marginale, Babesia Bovis and Babesia Bigemina in Different Breeds of Cattle and Rhipicephalus Microplus in the Northern Hainan, China

Bhowmick

Liu

et al. 2021

Preprint

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BackgroundAnaplasma marginale, Babesia bovis and Babesia bigemina cause huge economic losses to the world's cattle industry every year. At present, there are limited investigations on A. marginale, B. bovis and B. bigemina in Hainan. The purpose of this study was to investigate the infection of A.marginale, B.bovis and B.bigemina in different breeds of cattle (Leiqiong and Wagyu), buffaloes and Rhipicephalus microplus in the northern part of Hainan.MethodsIn this study, 63 R. microplus and 151 samples of bovine blood were collected from cattle in the northern part of Hainan. A. marginale, B. bovis and B. bigemina were detected by PCR and nPCR. ResultsThe results showed that the infection rates of A. marginale, B. bovis and B. bigemina in 214 samples were 10.75% (23/214), 4.21% (9/214) and 9.35% (20/214), respectively. In Leiqiong cattle, the total infection rate of several pathogens was the highest, which was 73.33% (22/30), and there was cross-infection of several pathogens, the infection rate was 46.67% (14/30). Among them, A. marginale and B. bigemina had the highest cross-infection rate, which was 26.67% (8/30). No mixed infection was detected in R. microplus, buffalo and Wagyu. Among buffalo, the infection rates of A. marginale, B. bovis and B. bigemina were 2.17% (1/46), 6.52% (3/46) and 4.35% (2/46), respectively. A. marginale infection was only found in Wagyu, with an infection rate of 2.67% (2/75). A. marginale and B. bigemina infections were found in R. microplus, but no B. bovis infection was found. ConclusionsThe results of this study provide a reference for the formulation of prevention and control strategies for A. marginale, B. bigemina and B. bovis in Hainan.

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“…asiaticum , D. nuttalli , Hy. anatolicum , Dermacentor pavlovsky , and Rhipicephalus sanguineus ( Wang Y. et al, 2015 ; Sheng et al, 2019 ; Li et al, 2020 ). These reports suggested that ticks, during their life cycles, had substantial contact with marmots and sheep, which indicated the potential for virus transmission between the tick vectors and animal hosts.…”

Section: Discussionmentioning

confidence: 99%

Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China

et al. 2022

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Despite few human cases of tick-borne encephalitis virus (TBEV), high rates of TBEV seroprevalence were reported among humans and animals in Xinjiang Uygur Autonomous Region in Northwestern China. In this study, the Karshi virus (KSIV) was identified and isolated from Hyalomma asiaticum ticks in Xinjiang. It belongs to the genus Flavivirus of the family Flaviviridae and is closely related to TBEV. KSIV infects cell lines from humans, other mammals and ticks, and causes encephalitis in suckling mice. High minimum infection rates (4.96%) with KSIV were detected among tick groups. KSIV infections have occurred in sheep and marmots, resulting in antibody-positive rates of 2.43 and 2.56%, respectively. We further found that, of the KSIV antibody-positive serum samples from animals, 13.9% had TBEV exposure showing cross-reaction to KSIV, and 11.1% had KSIV infection resulting in cross-reaction to TBEV; 8.3% were likely to have co-exposure to both viruses (or may be infected with one of them and present cross-reactivity with the other). The results revealed a substantial KSIV prevalence among ticks in Xinjiang, indicating exposure of animals to KSIV and TBEV. The findings implied misinterpretation of the high rates of TBEV seroprevalence among humans and animals in previous studies. There is a need to develop detection methods to distinguish KSIV from TBEV and to perform an in-depth investigation of KSIV and TBEV prevalence and incidence in Northwestern China, which would enhance our preparation to provide medical treatment of emerging diseases caused by tick-borne viral pathogens such as KSIV.

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Molecular detection of tick-borne pathogens harbored by ticks collected from livestock in the Xinjiang Uygur Autonomous Region, China

Cited by 26 publications

References 47 publications

Molecular Investigation on Tick-Borne Hemoparasites and Coxiella burnetii in Dromedary Camels (Camelusdromedarius) in Al Dhafra Region of Abu Dhabi, UAE

Molecular Investigation on Tick-Borne Hemoparasites and Coxiella burnetii in Dromedary Camels (Camelusdromedarius) in Al Dhafra Region of Abu Dhabi, UAE

First Molecular Detection of Anaplasma Marginale, Babesia Bovis and Babesia Bigemina in Different Breeds of Cattle and Rhipicephalus Microplus in the Northern Hainan, China

Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China

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