Molecular detection of multidrug-resistant Mycobacterium leprae from Indian leprosy patients

Molecular surveillance of antimicrobial resistance and transmission pattern of Mycobacterium leprae in Chinese leprosy patients

“…In newly diagnosed cases of leprosy, the high frequency of AMR to dapsone (six, 2.2%) in WHO-recommended DRDRs was identified in the present study , which was less than that in India [23], Korea [24], Myanmar, Indonesia, Philippines [25], Vietnam [26], and Brazil [3] but higher than that in Colombia [12] and China [27]. In this study, no mutation associated with rifampicin resistance was confirmed, whereas rifampicin resistance cases were confirmed in India [23], Brazil [28], China [27], Myanmar, Indonesia, and Philippines [25]. We reported that the AMR frequency for ofloxacin (two, 0.7%) was less in the current study leprosy population than that of Colombia [12], India [3], and China [27] leprosy population.…”

“…In relapse cases, the AMR to dapsone (one, 5%) and double mutation in both dapsone and ofloxacin (one, 5%) and rifampicin and ofloxacin (one, 5%) were less frequent than those found in Brazil [29] and Korea [24] but higher than those in India [23] and Colombia [12]. Other studies from Myanmar, Indonesia, Philippines [25], Vietnam [26], and South America [30] reported higher dapsone AMR cases than those observed in the present study.…”

Molecular docking and simulation study for synthesis of alternative dapsone derivative as a newer antileprosy drug in multidrug therapy

“…This problem was overcome to a certain extent after the introduction of WHO MDT in the year 1983 where a combinatorial therapy was used to treat leprosy in paucibacillary and multibacillary regimens. However, with the emergence of rifampicin resistance in the recent years in leprosy, the rates of leprosy relapse and resistance to MDT are gradually increasing, posing a threat to the current control measures . In this context, it is very important to develop new drugs or the modification of current drugs is very essential to treat leprosy.…”

“…This energy term may be considered to play a significant role in forming stable complexes because the negative van der Waals energy occurs in all simulation systems. 10,33 In this context, it is very important to develop new drugs or the modification of current drugs is very essential to treat leprosy. The expected negative electrostatic interactions were for Wt/Mt MlDHPSs-DD3/dapsone interactions, because it symbolizes the electrostatic attraction between the receptor and the ligands.…”

“…However, with the emergence of rifampicin resistance in the recent years in leprosy, the rates of leprosy relapse and resistance to MDT are gradually increasing, posing a threat to the current control measures. 10,33 In this context, it is very important to develop new drugs or the modification of current drugs is very essential to treat leprosy. In case of modifications to current drugs, it is important that bactericidal or bacteriostatic activity of the drug is enhanced and/or the drug can act on the resistant strains.…”