Molecular Detection of Campylobacter jejuni as a Cause of Culture-Negative Spondylodiscitis

Tappe, Dennis; Schulze, Marco H.; Oesterlein, Anett; Abele‐Horn, Marianne; Baron, Stefan; Durchholz, Daniel; Langen, H.-J.; Jany, B; Schoen, Christoph

doi:10.1128/jcm.06275-11

Cited by 6 publications

(6 citation statements)

References 9 publications

(20 reference statements)

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“…The results of our AST were in coherence with overall resistance patterns for C. jejuni in Denmark, where resistance to ciprofloxacin is reported in almost half of domestically acquired human C. jejuni cases [ 23 ]. In previous case reports with C. jejuni spondylodiscitis, treatment has consisted of fluoroquinolones, macrolides or carbapenems, for a total duration of 5–10 weeks [ 24 , 25 ]. While imipenem is commonly utilized in several countries, meropenem serves as the predominant carbapenem of choice in Denmark and was selected as the primary treatment for our patient in this case.…”

Section: Discussionmentioning

confidence: 99%

Vertebral osteomyelitis caused by Campylobacter jejuni in an immunocompetent patient

Kirk,

Boel,

Nielsen

2023

Gut Pathog

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Background Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide. However, systemic infection with C. jejuni is uncommon, and osteomyelitis caused by C. jejuni is extremely rare. Cultivation from spinal bone biopsies has not previously been reported in the literature. Case presentation A 79-year-old immunocompetent male was admitted to the emergency department at Aalborg University Hospital in Denmark with lower back pain, fever and diarrhoea. A FecalSwab obtained upon admission was PCR-positive for Campylobacter spp, while an aerobic blood culture bottle was positive for C. jejuni (Time to detection: 70.4 h). A MRI of columna totalis showed osteomyelitis at L1/L2 with an epidural abscess from L1 to L2 with compression of the dura sack. The patient underwent spinal surgery with spondylodesis and decompression of L1/L2. The surgery was uncomplicated and the discus material was also culture positive for C. jejuni. The patient was treated with meropenem for a total duration of four weeks, followed by four weeks of oral treatment with clindamycin in tapered dosage. The patient recovered quickly following surgery and targeted antibiotic treatment with decreasing lumbar pain and biochemical response and was fully recovered at follow-up three months after end of treatment. Conclusions While C. jejuni osteomyelitis is rare, it should still be suspected as a possible causative bacterial aetiology in patients with vertebral osteomyelitis, in particular when symptoms of diarrhoea is involved in the clinical presentation. Susceptibility testing is crucial due to emerging resistance, and targeted treatment strategies should rely upon such tests.

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Section: Discussionmentioning

confidence: 99%

Vertebral osteomyelitis caused by Campylobacter jejuni in an immunocompetent patient

Kirk,

Boel,

Nielsen

2023

Gut Pathog

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“…The optimal treatment has not yet been defined for CF infective spondylodiscitis, although erythromycin and fluoroquinolones are the recommended treatment for systemic campylobacteriosis ( 5 , 14 ). Nevertheless, it is paramount to accurately identify the causative pathogen in order to effectively prescribe targeted antimicrobial therapy and to select antibiotics that have good tissue penetration for such infections ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Campylobacter fetus caused pyogenic spondylodiscitis with a presentation of cauda equina syndrome after instrumented lumbar fusion surgery

2022

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Spondylodiscitis with/without neurologic impairment is a serious infection, predominantly occurring in high-risk patients. Campylobacter fetus caused spondylodiscitis is very rare. Evidence-based therapeutic concepts for lumbar spondylodiscitis are lacking. A 64-year-old high-risk woman underwent decompression with instrumented lumbar fusion. Six months after index surgery, she developed pyelonephritis, which deteriorated to sepsis and presentation of cauda equina syndrome. She underwent urgent revision with decompression, debridement, and instrumentation removal, and received long-term antibiotics. Culture grew Campylobacter fetus, previously not reported as a cause of spondylodiscitis after elective instrumented lumbar fusion. Emergent debridement and removal of instrumentation, with 2 months of targeted intravenous antibiotics followed by 6 weeks of oral antibiotics led to complete spondylodiscitis resolution. Prompt diagnostics and targeted antibiotic treatment are paramount when dealing with spinal infections, particularly in patients with rare causative pathogens like Campylobacter fetus. Concomitant neurological complications may require emergent surgical management in the case of cauda equina syndrome.

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Section: Discussionmentioning

confidence: 99%

“…Though erythromycin and fluoroquinolones are the recommended treatment for systemic campylobacteriosis [ 13 ], optimal treatment has not yet been defined for C. fetus infective spondylodiscitis. However, it is always important to select antibiotics that have good tissue penetration for such infections.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of infective spondylodiscitis caused by Campylobacter fetus subsp. fetus: molecular characterization by whole-genome sequencing

Prabaa

Lakshmi

Prakash

et al. 2021

Access Microbiology

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Spondylodiscitis is an infectious inflammation that affects the intervertebral disc and adjacent structures. Treating infective spondylodiscitis is often challenging due to the lack of specific symptoms. Here we present an unusual case of infective spondylodiscitis caused by Campylobacter fetus subsp. fetus .

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Molecular Detection of Campylobacter jejuni as a Cause of Culture-Negative Spondylodiscitis

Cited by 6 publications

References 9 publications

Vertebral osteomyelitis caused by Campylobacter jejuni in an immunocompetent patient

Vertebral osteomyelitis caused by Campylobacter jejuni in an immunocompetent patient

Case Report: Campylobacter fetus caused pyogenic spondylodiscitis with a presentation of cauda equina syndrome after instrumented lumbar fusion surgery

An unusual case of infective spondylodiscitis caused by Campylobacter fetus subsp. fetus: molecular characterization by whole-genome sequencing

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