Molecular Detection of a Novel Fowl Adenovirus Serotype-4 (FadV-4) from an Outbreak of Hepatitis Hydropericardium Syndrome in Commercial Broiler Chickens in Egypt

Sultan, Hesham; Arafa, Abdel Satar; Adel, Amany; Selim, Karim; Hossiny, Mohamed; Talaat, Shaimaa

doi:10.1637/0005-2086-65.3.385

Cited by 5 publications

(11 citation statements)

References 47 publications

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“…Two more viruses (10.5%) related to FAdV-3 were detected, and only one FAdV-1 was recorded. Although FAdV-4, the pathogenic type of FAdV, was not detected in the present study, a recent study reported the first detection of FAdV-4 in Egypt ( Sultan et al., 2021 ), which was isolated from a cubb broiler flock at age of 32 days in Alexandria. The flock had a 15% mortality rate, and the examined post mortem lesions seemed typical of a pathogenic type of FAdV.…”

Section: Discussioncontrasting

confidence: 58%

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Epidemiological and molecular analysis of circulating fowl adenoviruses and emerging of serotypes 1, 3, and 8b in Egypt

Adel

Halim

Samir

et al. 2021

Heliyon

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Fowl adenoviruses (FAdVs) are a large group of viruses of different serotypes. They are responsible for inclusion body hepatitis, adenoviral gizzard erosion, and hepatitis hydropericardium syndrome. The present study presents a comprehensive overview of FAdVs in Egypt, with a focus on the epidemiological features of virus serotypes across the country. We conducted molecular investigation of multiple FAdV species based on the genetic signature of hypervariable regions 1–4 in the loop1 (L1) region of the hexon gene. Epidemiologically, the Nile Delta governorates showed high positivity of FAdVs, which were more commonly found in broilers than in layers. Genetically, species D and serotype 8a/E dominated, and the findings also revealed the emergence of new FAdV serotypes 1, 3, and 8b. The comparative analysis of hypervariable regions in the L1 region of the hexon gene revealed variables specific to each virus serotype. In silico predictions of L1 region revealed variations in the molecular structure and predicted the antigenic epitopes which may affect the cross-antigenicity between the different FAdV species and serotypes.

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Section: Discussioncontrasting

confidence: 58%

“…The flock had a 15% mortality rate, and the examined post mortem lesions seemed typical of a pathogenic type of FAdV. The pathognomonic lesions were flappy heart with pericarditis and inflammatory fluid accumulation, in addition to an enlarged pale liver with petechial hemorrhage and necrotic foci ( Sultan et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and molecular analysis of circulating fowl adenoviruses and emerging of serotypes 1, 3, and 8b in Egypt

Adel

Halim

Samir

et al. 2021

Heliyon

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“…There has been an increase in reports of HHS and IBH outbreaks from various regions in the last ten years, such as in Europe [41][42][43][44], Asia [45][46][47][48][49], Oceania [30], North America [50], South America [51,52], and Africa [53,54], indicating even geographical spread of FAdVs. As in most Asian countries, FAdV-induced outbreaks in poultry have been observed in South Korea for many years, and, to date, these outbreaks persist.…”

Section: Introductionmentioning

confidence: 99%

Historical Investigation of Fowl Adenovirus Outbreaks in South Korea from 2007 to 2021: A Comprehensive Review

2021

Viruses

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Fowl adenoviruses (FAdVs) have long been recognized as critical viral pathogens within the poultry industry, associated with severe economic implications worldwide. This specific group of viruses is responsible for a broad spectrum of diseases in birds, and an increasing occurrence of outbreaks was observed in the last ten years. Since their first discovery forty years ago in South Korea, twelve antigenically distinct serotypes of fowl adenoviruses have been described. This comprehensive review covers the history of fowl adenovirus outbreaks in South Korea and updates the current epidemiological landscape of serotype diversity and replacement as well as challenges in developing effective broadly protective vaccines. In addition, transitions in the prevalence of dominant fowl adenovirus serotypes from 2007 to 2021, alongside the history of intervention strategies, are brought into focus. Finally, future aspects are also discussed.

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“…In terms of HHS, Sultan et al ( 55 ) reported for the first time a pathogenic fowl aviadenovirus-4 (FAdV-4) in a Cobb-500 broiler flock aged 32 days in Alexandria governorate, Egypt in 2021. This flock had a high mortality rate (15%), depression, greenish diarrhea, a flabby heart with a pericardial sac filled with straw-colored fluid, a pale enlarged friable liver with hemorrhage, necrotic foci, and an edematous kidney.…”

Section: Current Status Of Ibh And/or Hhs Associated Problemsmentioning

confidence: 99%

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

et al. 2022

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Infection with fowl adenoviruses (FAdVs) can result in a number of syndromes in the production of chicken, including inclusion body hepatitis (IBH), hepatitis-hydropericardium syndrome (HHS), and others, causing enormous economic losses around the globe. FAdVs are divided into 12 serotypes and five species (A–E; 1–8a and 8b−11). Most avian species are prone to infection due to the widespread distribution of FAdV strains. The genus aviadenovirus, which is a member of the adenoviridae family, is responsible for both IBH and HHS. The most popular types of transmission are mechanical, vertical, and horizontal. Hepatitis with basophilic intranuclear inclusion bodies distinguishes IBH, but the buildup of translucent or straw-colored fluid in the pericardial sac distinguishes HHS. IBH and HHS require a confirmatory diagnosis because their clinical symptoms and postmortem abnormalities are not unique to those conditions. Under a microscope, the presence of particular lesions and inclusion bodies may provide clues. Traditional virus isolation in avian tissue culture is more delicate than in avian embryonated eggs. Additionally, aviadenovirus may now be quickly and precisely detected using molecular diagnostic tools. Preventive techniques should rely on efficient biosecurity controls and immunize breeders prior to production in order to protect progeny. This current review gives a general overview of the current local and global scenario of IBH, and HHS brought on by FAdVs and covers both their issues and preventative vaccination methods.

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Molecular Detection of a Novel Fowl Adenovirus Serotype-4 (FadV-4) from an Outbreak of Hepatitis Hydropericardium Syndrome in Commercial Broiler Chickens in Egypt

Cited by 5 publications

References 47 publications

Epidemiological and molecular analysis of circulating fowl adenoviruses and emerging of serotypes 1, 3, and 8b in Egypt

Epidemiological and molecular analysis of circulating fowl adenoviruses and emerging of serotypes 1, 3, and 8b in Egypt

Historical Investigation of Fowl Adenovirus Outbreaks in South Korea from 2007 to 2021: A Comprehensive Review

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

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