Molecular Detection and Phylogenetic Characterization of Bat and Human Adenoviruses in Southern China

Zheng, Xianrui; Qiu, Min; Chen, Huifang; Chen, Shaowei; Xiao, Jianpeng; Jiang, Lina; Huo, Shuting; Shi, Ting-li; Ma, Lizhen; Liu, Shan; Zhou, Junhua; Zhang, Qionghua; Li, Xing; Chen, Zhong; Wu, Yi; Li, Jinming; Guan, Weijun; Xiong, Yiquan; Ma, Shujuan; Zhong, Xiaomei; Ge, Jun; Cen, Shu-Wen; Chen, Qing

doi:10.1089/vbz.2015.1892

Cited by 7 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, phylogenetic analysis revealed an expected strain-host specificity independent of geographical distance, in line with previous findings for the targeted viral families [1,28,[56][57][58][62][63][64][65][66][67][68]. At a finer scale, clustering patterns of coronavirus strains for C. gouldii and C. morio, may reflect the ecological connectivity between host populations.…”

Section: Discussionsupporting

confidence: 89%

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Prada

Boyd

Baker

et al. 2019

Viruses

View full text Add to dashboard Cite

Bats are known reservoirs of a wide variety of viruses that rarely result in overt clinical disease in the bat host. However, anthropogenic influences on the landscape and climate can change species assemblages and interactions, as well as undermine host-resilience. The cumulative result is a disturbance of bat-pathogen dynamics, which facilitate spillover events to sympatric species, and may threaten bat communities already facing synergistic stressors through ecological change. Therefore, characterisation of viral pathogens in bat communities provides important basal information to monitor and predict the emergence of diseases relevant to conservation and public health. This study used targeted molecular techniques, serological assays and next generation sequencing to characterise adenoviruses, coronaviruses and paramyxoviruses from 11 species of insectivorous bats within the South West Botanical Province of Western Australia. Phylogenetic analysis indicated complex ecological interactions including virus-host associations, cross-species infections, and multiple viral strains circulating concurrently within selected bat populations. Additionally, we describe the entire coding sequences for five alphacoronaviruses (representing four putative new species), and one novel adenovirus. Results indicate that viral burden (both prevalence and richness) is not homogeneous among species, with Chalinolobus gouldii identified as a key epidemiological element within the studied communities.

show abstract

Section: Discussionsupporting

confidence: 89%

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Prada

Boyd

Baker

et al. 2019

Viruses

View full text Add to dashboard Cite

show abstract

“…HAdV-C, and -D were detected in humans; however, the HAdV-C genes in humans and gorillas wer genetically distinct.Phylogenetic: nested PCR targeting DPOL and hexon genes. Nucleotide sequences of amplicons confirmed using BLAST23.Zheng et al [46]China, 2016Rectal swabs from bats and stool samples from outpatients with diarrhea were analyzed for bat and human AdVs. All bat and human AdVs detected were mastadenoviruses but only 57.1–69.3% aa similarity was detected between the two.Phylogenetic: nested PCR targeting DPOL gene.…”

Section: Resultsmentioning

confidence: 99%

Are adenoviruses zoonotic? A systematic review of the evidence

Borkenhagen

Fieldhouse

Seto

et al. 2019

Emerging Microbes & Infections

View full text Add to dashboard Cite

Adenoviruses (AdVs) are major contributors to clinical illnesses. Novel human and animal AdVs continue to be identified and characterized. Comparative analyses using bioinformatic methods and Omics-based technologies allow insights into how these human pathogens have emerged and their potential for host cross-species transmission. Systematic review of literature published across ProQuest, Pubmed, and Web of Science databases for evidence of adenoviral zoonotic potential identified 589 citations. After removing duplicates, 327 citations were screened for relevance; of which, 74 articles received full-text reviews. Among these, 24 were included here, of which 16 demonstrated evidence of zoonotic transmission of AdVs. These documented instances of AdV crossing host species barriers between humans and non-human primate, bat, feline, swine, canine, ovine, and caprine. Eight studies sought to but did not find evidence of zoonosis. The findings demonstrate substantial evidence suggesting AdVs have previously and will continue crossing host species barriers. These have human health consequences both in terms of novel pathogen emergence and epidemic outbreaks, and of appropriate and safe use of nonhuman adenoviruses for therapeutics. As routine human clinical diagnostics may miss a novel cross-species adenovirus infection in humans, next generation sequencing or panspecies molecular diagnostics may be necessary to detect such incursions.

show abstract

“…The highest density of sampling localities was found in Europe, central Africa, and eastern Asia (Figure 3), whereas vast regions in all continents still stand out for the lack of studies on this matter, such as Canada in the Nearctic Region, north Africa, and the Middle East, all the way to central or northern Asia or even in Australia. The highest number of AdV-positive bat species was reported from China, with 30 positive species [23,26,28,32,40,78,79,88,91] out of 147 species reported for the country [101]. This vast country has shown an increasing interest in studying viruses in bats; in fact, the study on viruses hosted by bats is the bat topic most intensively studied in this country [101].…”

Section: Adenoviridaementioning

confidence: 99%

Surveying Bat-Hosted Adenoviruses and Herpesviruses: A Comprehensive Analysis

Méndez-Rodríguez,

Horta,

Zarza

et al. 2024

Diversity

View full text Add to dashboard Cite

Bats have gained cumulative attention as potential reservoirs for viruses, being crucial to increase our ability to predict viral prevalence and transmissions, as well as support the possible management of future zoonotic episodes. Following the PRISMA standard systematic review protocols, we conducted a comprehensive search worldwide for scientific papers dealing with bat-hosted viruses of the Adenoviridae and Herpesviridae families. The search was completed using the Scopus, CABI, and SciELO, databases of bat-associated viruses of these two families as well as the Google Scholar search engine. Our search comprised a total of 2656 scientific papers. After a thorough review and screening of the papers, we selected for our study a total of 90 papers published between 1996 and 2022. We found marked taxonomic and spatial biases, the most studied bats being predominantly vespertilionids, rhinolophids, phyllostomids, and pteropodids, whereas other families (e.g., Natalidae, Noctilionidae, and Furipteridae) are still lacking information. The most studied areas are southern and east Asia, although there are large areas (north Africa, the Middle East, and all the way to central or northern Asia) still overlooked. Out of the total number of papers, as many as 55 identified bat-hosted Adenovirus (AdV) and 54 papers identified Herpesvirus (HSV). Our revision reveals the presence of AdVs in a total of 97 bat species from 42 genera and 11 families. The presence of HSVs is reported also in 109 bat species from 45 genera and 10 families. Although both AdVs and HSVs in general show a clear host specificity and parallel evolution with their hosts, these results also point to the potential of these viruses to cross, in some cases, species barriers.

show abstract

Molecular Detection and Phylogenetic Characterization of Bat and Human Adenoviruses in Southern China

Cited by 7 publications

References 13 publications

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Are adenoviruses zoonotic? A systematic review of the evidence

Surveying Bat-Hosted Adenoviruses and Herpesviruses: A Comprehensive Analysis

Contact Info

Product

Resources

About