Molecular Design Principles to Target mRNA Delivery With One-Component Ionizable Amphiphilic Janus Dendrimers Derived From Plant Phenolic Acids

Lu, Juncheng; Atochina‐Vasserman, Elena N.; Maurya, Devendra S.; Shalihin, Muhammad Irhash; Zhang, David; Cenna, Srijay S.; Adamson, Jasper; Liu, Matthew Tingchi; Shah, Habib-ur-Rehman; Shah, Honey; Xiao, Qi; Queeley, Bryn; Ona, Nathan; Reagan, Erin; Ni, Houping; Sahoo, Dipankar; Peterca, Mihai; Weissman, Drew; Percéc, Virgil

doi:10.2139/ssrn.4295382

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Nucleic Acid Delivery1

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2023

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“…A methodology utilizing screening libraries was employed to discover the essential molecular design principles required for targeted mRNA delivery to organs and the facilitation of activity using a single-component ionizable multifunctional IAJD derived from plant phenolic acids. 35 These IAJDs co-assembled with mRNA, forming monodisperse DNPs with predictable dimensions through the straightforward process of injecting their ethanol solution into a buffer. The strategic placement of functional groups in the 1-component IAJDs demonstrated that hydrophilic regions determined the targeted organs, such as the liver, spleen, lymph nodes, and lungs, while the hydrophobic domain governed their activity.…”

Section: Nucleic Acid Deliverymentioning

confidence: 99%