Molecular design of antibrowning agents: antioxidative tyrosinase inhibitors

Kubo, Isao; Chen, Qing‐Xi; Nihei, Keiji

doi:10.1016/s0308-8146(02)00418-1

Cited by 121 publications

(85 citation statements)

References 16 publications

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“…The preliminary chemical examination of the crude extract of C. argentea var. cristata has demonstrated the presence of phenolic and flavonoid compounds which may contribute to its tyrosinase inhibitory effect as reported earlier (Kubo et al, 2003;Nagendra et al, 2009). Anti-oxidant activity also affect tyrosinase activity (Kim et al, 2008).…”

Section: Discussionsupporting

confidence: 61%

In vitro inhibitory potential of methanolic extract of Celosia argentea var. cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

Saqib

Janbaz

Sherwani

2015

Bangladesh J Pharmacol

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In the current study, methanol extract of Celosia argentea var. cristata was tested for its inhibitory potential against tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes at the concentration of 0.5 mM by ELISA microtiter plate assays. A significant tyrosinase inhibitory activity (63.6%), acetylcholinesterase inhibitory activity (80.3%) and butyrylcholinesterse inhibitory activity (68.24%) was shown by crude methanolic extract of C. argentea var. cristata with respective IC50 values of 268.5 ± 0.2 µg/mL, 73.6 ± 0.1 µg/mL and 132.8 ± 0.9 µg/mL. The result of this study reveals the use of C. argentea var. cristata in skin hyperpigmentation, Parkinson’s disease and neurodegenerative disorders like Alzheimer’s disease and dementia.

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Section: Discussionsupporting

confidence: 61%

In vitro inhibitory potential of methanolic extract of Celosia argentea var. cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

Saqib

Janbaz

Sherwani

2015

Bangladesh J Pharmacol

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“…Reduction of dopaquinone formation results in the inhibition of melanin formation. Thus, it can be reasonably assumed that the anti-tyrosinase activity of polysaccharide is attributed to its antioxidant property [33]. Hydroxyl groups of polysaccharide could form hydrogen bonds to a site on the enzyme, leading to steric hindrance or conformational change [34].…”

Section: Inhibition Of Tyrosinase Activitymentioning

confidence: 99%

Improved antioxidant and anti-tyrosinase activity of polysaccharide from Sargassum fusiforme by degradation

Chen

Shi

Cui

et al. 2016

International Journal of Biological Macromolecules

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2 Highlights The degradation conditions of polysaccharide from S. fusiforme has been optimized. The antioxidant activity of the degraded polysaccharides was greatly improved. The degraded polysaccharides possess superior anti-tyrosinase activity.Abstract: An efficient method for the degradation of polysaccharides isolated from Sargassum fusiforme (PSF) was developed by using ascorbic acid in combination with H2O2. The degradation conditions were optimized using a Box-Behnken response surface design (BBRS). The optimum conditions were established as: concentration of ascorbic acid (VC) and H2O2 17.26 mM, degradation temperature 51 o C and degradation time 1.6 h. The DPPH radical scavenging rate of the degraded polysaccharides from S. fusiforme (DPSF) obtained under the optimal conditions was determined to be 75.22±0.02%, which was well matched with the value (75.21%) predicted by the BBRS model. In vitro antioxidant activity of the polysaccharides was evaluated by determining their radical (hydroxyl radical, superoxide anion radical and DPPH radical) scavenging abilities, and ferric iron reducing power. The inhibitory activity on tyrosinase of DPSF was also evaluated. The results indicate that the degraded polysaccharide has superior antioxidant activity and anti-tyrosinase effect to those of the original polysaccharide.

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“…P. lentiscus leaves contain flavonoids, phenolic acids such as catechin, β-glucogallin, quercitrin gallate, gallic acid and epicatechin [90][91][92]. Gallic acid and epicatechins, catechins are responsible for the potent tyrosinase inhibition capacity of P. lentiscus and could therefore be effective in the treatment of hyperpigmentation [93][94][95].…”

Section: Active Ingredients With Skin Whitening Propertiesmentioning

confidence: 99%

Applications for Marine Resources in Cosmetics

2017

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Abstract:Marine resources represent an interesting source of active ingredients for the cosmetics industry. Algae (macro and micro) are rich in proteins, amino acids, carbohydrates, vitamins (A, B, and C) and oligo-elements such as copper, iron and zinc. All those active principles play roles in hydration, firming, slimming, shine and protection. Marine organisms inhabit a wide spectrum of habitats. Photo-protective compounds can be obtained from organisms subjected to strong light radiation, such as in tropical systems or in shallow water. In the same way, molecules with antioxidant potential can be obtained from microorganisms inhabiting extreme systems such as hydrothermal vents. For example, marine bacteria collected around deep-sea hydrothermal vents produce complex and innovative polysaccharides in the laboratory which are useful in cosmetics. There are many properties that will be put forward by the cosmetic industries.

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Molecular design of antibrowning agents: antioxidative tyrosinase inhibitors

Cited by 121 publications

References 16 publications

<i>In vitro</i> inhibitory potential of methanolic extract of <i>Celosia argentea</i> var. <i>cristata</i> on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

<i>In vitro</i> inhibitory potential of methanolic extract of <i>Celosia argentea</i> var. <i>cristata</i> on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

Improved antioxidant and anti-tyrosinase activity of polysaccharide from Sargassum fusiforme by degradation

Applications for Marine Resources in Cosmetics

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