Molecular design and virtual screening of novel heterocyclic derivatives as Glucokinase activators
Anuradha Mehra,
Pankaj Wadhwa,
Amit Mittal
et al.
Abstract:Background: Deficiency of insulin signaling in type 2 diabetes results from insulin resistance or defective insulin secretion and induce hyperglycemia. Diabetes is a global threat that continues to increase day by day at a very high rate in both developing and developed countries. Glucokinase activators (GKA) can be a novel target used for better management of type 2 diabetes. Recently novel GKA Dorzagliatin received market approval by Japan FDA for treatment of type 2 diabetes.
Objective: The purpose of desi… Show more
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