Molecular Cytogenetic Evidence of Rearrangements on the Y Chromosome of the Threespine Stickleback Fish

Ross, Joseph A.; Peichel, Catherine L.

doi:10.1534/genetics.108.088559

Cited by 89 publications

(173 citation statements)

References 72 publications

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“…We found that N. furzeri has a genetic sex-determination system, with males as the heterogametic sex, indicative of an XY/XX system. The male sex-determining region in N. furzeri harbors a nonrecombining region, similar to that in medaka, guppies, platyfish, and sticklebacks (Kondo et al 2001;Matsuda et al 2002;Nanda et al 2002;Volff and Schartl 2002;Peichel et al 2004;Schultheis et al 2006;Ross and Peichel 2008;Shapiro et al 2009;Tripathi et al 2009a). In line with sticklebacks and medaka (Kondo et al 2001;Peichel et al 2004;Shapiro et al 2009), the sex linkage group in N. furzeri does show major differences in recombination rates when computed independently for males and females, and N. furzeri males consistently share a sex haplotype.…”

Section: Tablementioning

confidence: 56%

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Mapping Loci Associated With Tail Color and Sex Determination in the Short-Lived Fish Nothobranchius furzeri

Valenzano

Kirschner²,

Kamber

et al. 2009

Genetics

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The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which make N. furzeri a unique vertebrate system for studying the genetic basis of these traits. We mapped regions of the genome involved in sex determination and tail color by genotyping microsatellite markers in the F 2 progeny of a cross between a short-lived, yellow-tailed strain and a long-lived, red-tailed strain of N. furzeri. We identified one region linked with the yellow/red tail color that maps close to melanocortin 1 receptor (mc1r), a gene involved in pigmentation in several vertebrate species. Analysis of the segregation of sex-linked markers revealed that N. furzeri has a genetic sex determination system with males as the heterogametic sex and markedly reduced recombination in the male sex-determining region. Our results demonstrate that both naturally-evolved pigmentation differences and sex determination in N. furzeri are controlled by simple genetic mechanisms and set the stage for the molecular genetic dissection of factors underlying such traits. The microsatellite-based linkage map we developed for N. furzeri will also facilitate analysis of the genetic architecture of traits that characterize this group of vertebrates, including short life span and adaptation to extreme environmental conditions.

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Section: Tablementioning

confidence: 56%

“…some in another species of medaka (Oryzias latipes) (Matsuda et al 2002;Kasahara et al 2007) and with the sex-determining LGs in two stickleback species (Peichel et al 2004;Ross and Peichel 2008;Shapiro et al 2009), suggesting that the sex-determination system of N. furzeri probably arose independently of these species.…”

Section: Resultsmentioning

confidence: 99%

Mapping Loci Associated With Tail Color and Sex Determination in the Short-Lived Fish Nothobranchius furzeri

Valenzano

Kirschner²,

Kamber

et al. 2009

Genetics

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“…Ming unpublished). Inversions and deletions were also found in the Y chromosome of three-spined stickleback fish (Ross and Peichel 2008). Numerous chromosomal rearrangements were found between human and chimpanzee Y chromosomes, whereas the human and chimpanzee chromosome 21 were collinear (Hughes et al 2010).…”

Section: Molecular Dynamics Of the Sex-determining Regionmentioning

confidence: 96%

The sex-specific region of sex chromosomes in animals and plants

et al. 2011

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Our understanding of the evolution of sex chromosomes has increased greatly in recent years due to a number of molecular evolutionary investigations in divergent sex chromosome systems, and these findings are reshaping theories of sex chromosome evolution. In particular, the dynamics of the sex-determining region (SDR) have been demonstrated by recent findings in ancient and incipient sex chromosomes. Radical changes in genomic structure and gene content in the male specific region of the Y chromosome between human and chimpanzee indicated rapid evolution in the past 6 million years, defying the notion that the pace of evolution in the SDR was fast at early stages but slowed down overtime. The chicken Z and the human X chromosomes appeared to have acquired testisexpressed genes and expanded in intergenic regions. Transposable elements greatly contributed to SDR expansion and aided the trafficking of genes in the SDR and its X or Z counterpart through retrotransposition. Dosage compensation is not a destined consequence of sex chromosomes as once thought. Most X-linked microRNA genes escape silencing and are expressed in testis. Collectively, these findings are challenging many of our preconceived ideas of the evolutionary trajectory and fates of sex chromosomes.

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“…There were no known genes related to sexual differentiation in the chicken chromosome segment homologous to this region; however, WT1, which is a significant nuclear zinc-finger transcription factor that is required for early kidney and gonad development in mammals (Haber et al 1991;Armstong et al 1992;Kreidberg et al 1993;Rackley et al 1993;Roberts 2005), was localized to the subcentromeric region of the long arm of Y chromosome in this species. The three-spined stickleback (Gasterosteus aculeatus) and Nile tilapia (Oreochromis niloticus) have duplicated WT1 genes, and one of them is located on the X and Y sex chromosomes in both species (Ross and Peichel 2008;Lee and Kocher 2007). Three inversions occurred in the chromosomal region containing the Y-linked WT1 gene in the stickleback (Ross and Peichel 2008); however, the role of the Y-linked WT1 gene for gonadal differentiation is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The three-spined stickleback (Gasterosteus aculeatus) and Nile tilapia (Oreochromis niloticus) have duplicated WT1 genes, and one of them is located on the X and Y sex chromosomes in both species (Ross and Peichel 2008;Lee and Kocher 2007). Three inversions occurred in the chromosomal region containing the Y-linked WT1 gene in the stickleback (Ross and Peichel 2008); however, the role of the Y-linked WT1 gene for gonadal differentiation is unknown. In turtles, WT1 expression has been examined in two TSD and one GSD species (Spotila et al 1998;Valenzuela 2007).…”

Section: Discussionmentioning

confidence: 99%

The origin and differentiation process of X and Y chromosomes of the black marsh turtle (Siebenrockiella crassicollis, Geoemydidae, Testudines)

2011

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The black marsh turtle (Siebenrockiella crassicollis) has morphologically differentiated X and Y sex chromosomes. To elucidate the origin and evolutionary process of S. crassicollis X and Y chromosomes, we performed cross-species chromosome painting with chromosome-specific DNA from Chinese soft-shelled turtle (Pelodiscus sinensis) and chromosome mapping of the sex-linked genes of S. crassicollis using FISH. The X and Y chromosomes of S. crassicollis were hybridized with DNA probe of P. sinensis chromosome 5, which is homologous to chicken chromosome 5. S. crassicollis homologues of 14 chicken chromosome 5-linked genes were all localized to the X long arm, whereas two genes were mapped to the Y short arm and the other 12 genes were localized to the Y long arm in the same order as the X chromosome. This result suggests that extensive linkage homology has been retained between chicken chromosome 5 and S. crassicollis X and Y chromosomes and that S. crassicollis X and Y chromosomes are at an early stage of sex chromosome differentiation. Comparison of the locations of two site-specific repetitive DNA sequences on the X and Y chromosomes demonstrated that the centromere shift was the result of centromere repositioning, not of pericentric inversion.

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Molecular Cytogenetic Evidence of Rearrangements on the Y Chromosome of the Threespine Stickleback Fish

Cited by 89 publications

References 72 publications

Mapping Loci Associated With Tail Color and Sex Determination in the Short-Lived Fish Nothobranchius furzeri

Mapping Loci Associated With Tail Color and Sex Determination in the Short-Lived Fish Nothobranchius furzeri

The sex-specific region of sex chromosomes in animals and plants

The origin and differentiation process of X and Y chromosomes of the black marsh turtle (Siebenrockiella crassicollis, Geoemydidae, Testudines)

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