Molecular confirmation of an adenovirus in brushtail possums (Trichosurus vulpecula)

Thomson, Darelle; Meers, J.; Harrach, Balázs

doi:10.1016/s0168-1702(01)00437-3

Cited by 54 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Members of Mastadenovirus are found in mammals, and aviadenoviruses are found in birds. Atadenoviruses have been found in birds (Harrach et al, 1997) and mammals (Dán et al, 1998;Thomson et al, 2002), but it appears that their most probable origin is in squamates (Harrach, 2000;Benkö et al, 2002;Farkas et al, 2002;Wellehan et al, 2004). Siadenoviruses have been found in birds (Pitcovski et al, 1998), tortoises (Rivera et al, 2009), and amphibians (Davison et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Siadenovirus infection in two psittacine bird species

et al. 2009

View full text Add to dashboard Cite

Consensus polymerase chain reaction was used to identify a novel adenovirus from two psittacine birds: a plum-headed parakeet (Psittacula cyanocephala) with lethargy, weight loss, and marked leukocytosis; and an umbrella cockatoo (Cacatua alba) with lethargy, weight loss, and feather abnormalities. Phylogenetic and comparative sequence analysis suggested that this virus is a member of the genus Siadenovirus, and is here termed psittacine adenovirus 2. This extends the characterized adenoviruses of psittacine birds beyond Aviadenovirus to include the genus Siadenovirus. Identification and further study of adenoviral types and species will provide useful diagnostic, prognostic, and epidemiologic information for the clinician. Like other known members of the genus Siadenovirus, Psittacine adenovirus 2 is AT-rich over the region sequenced, and it is hypothesized that this may be associated with shorter hostÁvirus evolutionary association.

show abstract

Section: Introductionmentioning

confidence: 99%

Siadenovirus infection in two psittacine bird species

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Atadenoviruses from ruminants (3,8,11,32,33), birds (21,23), snakes (4,15,34), and a marsupial (44) were isolated and studied. The two siadenoviruses were from a frog (14) and poultry (39).…”

mentioning

confidence: 99%

Detection and Analysis of Six Lizard Adenoviruses by Consensus Primer PCR Provides Further Evidence of a Reptilian Origin for the Atadenoviruses

Wellehan¹,

Johnson²,

Harrach

et al. 2004

J Virol

276

247

View full text Add to dashboard Cite

A consensus nested-PCR method was designed for investigation of the DNA polymerase gene of adenoviruses. Gene fragments were amplified and sequenced from six novel adenoviruses from seven lizard species, including four species from which adenoviruses had not previously been reported. Host species included Gila monster, leopard gecko, fat-tail gecko, blue-tongued skink, Tokay gecko, bearded dragon, and mountain chameleon. This is the first sequence information from lizard adenoviruses. Phylogenetic analysis indicated that these viruses belong to the genus Atadenovirus, supporting the reptilian origin of atadenoviruses. This PCR method may be useful for obtaining templates for initial sequencing of novel adenoviruses.

show abstract

“…One potential option for fertility control in New Zealand is to search for a cultivable possum adenovirus. Adenovirus has been identified by electron microscopy and molecular biology from possums of New Zealand, and one possum isolate has been characterised on a phylogenetic basis as belonging to the group Atadenoviridae (Thomson et al 2002). However, the in vitro propagation, in vivo transmission, amenability to genetic modification, possum infectivity, epidemiology, host range and host immune response to this virus have not been reported.…”

Section: Recombinant Adenovirusesmentioning

confidence: 99%

Could recombinant technology facilitate the realisation of a fertility-control vaccine for possums?

Cross

Zheng

Duckworth

et al. 2011

New Zealand Journal of Zoology

View full text Add to dashboard Cite

While lethal control remains the primary tool for possum control in New Zealand, there has been substantial research effort over the last decade into controlling possum populations by reducing the animals' breeding potential. In particular, the potential of immunological control to reduce fertility has been investigated, whereby the possums' immune system is induced to react against its reproductive system, in order to block or destroy key components of the reproductive process. Two of the most targeted key components have been the blocking of circulating hormones (e.g. gonadotrophin-releasing hormone) and the inhibition of functional egg surface proteins (e.g. zona pellucida). While some success has been achieved for each approach, three main obstacles remain to the development of a working fertility-control vaccine for possums: first, ensuring that the vaccine remains efficacious in oral-delivery formulation; second, ensuring sufficient levels of fertility reduction; and third, ensuring that the induced immune response is sustained for a duration sufficient for long-term suppression of reproduction. The use of a genetically modified recombinant organism (parasite, bacterium or virus) to deliver a fertility-control vaccine could satisfy these requirements. A strong precedent for this approach has been set already in wildlife biology, namely the oral rabies vaccine, which is based on a recombinant vaccinia virus and which has been used successfully for the last 25 years as a disease-eliminating vaccine in mesocarnivores in Europe and North America. This review outlines the different forms and examples of recombinant organisms with potential for engineering into recombinant fertilitycontrol vaccines to reduce possum reproduction; non-transmissible agents or fully-transmissible vectors are discussed, with shortcomings and benefits outlined for each.

show abstract

Molecular confirmation of an adenovirus in brushtail possums (Trichosurus vulpecula)

Cited by 54 publications

References 22 publications

Siadenovirus infection in two psittacine bird species

Siadenovirus infection in two psittacine bird species

Detection and Analysis of Six Lizard Adenoviruses by Consensus Primer PCR Provides Further Evidence of a Reptilian Origin for the Atadenoviruses

Could recombinant technology facilitate the realisation of a fertility-control vaccine for possums?

Contact Info

Product

Resources

About