Molecular composition and expression pattern of the extracellular matrix in a mossy fiber-generating precerebellar nucleus of rat, the prepositus hypoglossi

Gaál, Botond; Kecskes, Szilvia; Matesz, Clara; Birinyi, András; Hunyadi, Andrea; Rácz, Éva

doi:10.1016/j.neulet.2015.03.056

Cited by 8 publications

(3 citation statements)

References 52 publications

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“…The PHN expresses several extracellular matrix (ECM) molecules that form perineuronal nets (Gaál et al, 2015). Among these ECM molecules, aggrecan and neurocan are intensely expressed in the ventromedial region of the PHN (Gaál et al, 2015), which may correspond to the regions of preposito‐VM and preposito‐PC neuronal assembly. Because the ECM and perineuronal nets participate in the modulation of synaptic transmission (Dityatev, Schachner, & Sonderegger, 2010; Zimmermann & Dours‐Zimmermann, 2008), the activity of preposito‐VM and preposito‐PC neurons may be regulated by the ECM.…”

Section: Discussionmentioning

confidence: 99%

“…Although numerous preposito‐UN neurons were observed in the caudal region of the PHN, they were loosely assembled. The PHN expresses several extracellular matrix (ECM) molecules that form perineuronal nets (Gaál et al, 2015). Among these ECM molecules, aggrecan and neurocan are intensely expressed in the ventromedial region of the PHN (Gaál et al, 2015), which may correspond to the regions of preposito‐VM and preposito‐PC neuronal assembly.…”

Section: Discussionmentioning

confidence: 99%

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Distinct proportions of cholinergic neurons in the rat prepositus hypoglossi nucleus according to their cerebellar projection targets

Sugimura

Saito

2020

J of Comparative Neurology

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Cerebellar functions are modulated by cholinergic inputs, the density of which varies among cerebellar regions. Although the prepositus hypoglossi nucleus (PHN), a brainstem structure involved in controlling gaze holding, is known as one of the major sources of these cholinergic inputs, the proportions of cholinergic neurons in PHN projections to distinct cerebellar regions have not been quantitatively analyzed. In this study, we identified PHN neurons projecting to the cerebellum by applying retrograde labeling with dextran-conjugated Alexa 488 in choline acetyltransferase (ChAT)-tdTomato transgenic rats and compared the proportion of cholinergic PHN neurons in the PHN projections to four different regions of the cerebellum, namely the flocculus (FL), the uvula and nodulus (UN), lobules III-V in the vermis (VM), and the hemispheric paramedian lobule and crus 2 (PC). In the PHN, the percentage of cholinergic PHN neurons was lower in the projection to the FL than in the projection to the UN, VM or PC. Preposito-cerebellar neurons, except for preposito-FL neurons, included different proportions of cholinergic neurons at different rostrocaudal positions in the PHN. These results suggest that cholinergic PHN neurons project to not only the vestibulocerebellum but also the anterior vermis and posterior hemisphere and that the proportion of cholinergic neurons among projection neurons from the PHN differs depending on cerebellar target areas and the rostro-caudal regions of the PHN. This study provides insights regarding the involvement of cerebellar cholinergic networks in gaze holding.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distinct proportions of cholinergic neurons in the rat prepositus hypoglossi nucleus according to their cerebellar projection targets

Sugimura

Saito

2020

J of Comparative Neurology

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“…CSPGs are key contributors to the composition of PNNs [ 167 – 169 ] and are also found in other structures described as perisynaptic coats [ 154 , 170 – 174 ]. An increasing number of studies show that these molecules are critically involved in the regulation of synaptic plasticity.…”

Section: Schizophreniamentioning

confidence: 99%

In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders

2016

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Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. In many of these disorders, PNN abnormalities have also been reported. In the context of the “quadripartite” synapse concept, that is, the functional unit composed of the pre- and postsynaptic terminals, glial processes, and ECM, and of the role that PNNs and ECM molecules play in regulating synaptic functions and plasticity, these findings resonate with one of the most well-replicated aspects of the pathology of psychiatric disorders, that is, synaptic abnormalities. Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction.

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Development of the human perihypoglossal nuclei from mid-gestation to the perinatal period: A morphological study

Yamaguchi

Yazawa

2022

Neuroscience Letters

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Molecular composition and expression pattern of the extracellular matrix in a mossy fiber-generating precerebellar nucleus of rat, the prepositus hypoglossi

Cited by 8 publications

References 52 publications

Distinct proportions of cholinergic neurons in the rat prepositus hypoglossi nucleus according to their cerebellar projection targets

Distinct proportions of cholinergic neurons in the rat prepositus hypoglossi nucleus according to their cerebellar projection targets

In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders

Development of the human perihypoglossal nuclei from mid-gestation to the perinatal period: A morphological study

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