Molecular Comparison of Dengue Type 1 Mochizuki Strain Virus and Other Selected Viruses Concerning Nucleotide and Amino Acid Sequences of Genomic RNA: A Consideration of Viral Epidemiology and Variation

Edward, Zulkarnain; Hotta, Susumu; Takegami, Tsutomu

doi:10.1111/j.1348-0421.1994.tb01826.x

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…Studies carried out in epidemic regions led to the generation of hypotheses about the development of SD [ 28 ]. They include antibody-mediated pathogenesis [ 4 ], host cytokine storms [ 29 ], host genetic factors [ 24 ], characteristics of virus isolates [ 30 – 32 ], viral load in the acute phase [ 33 , 34 ], and the host nutritional status [ 35 ]. DENV can interact with dendritic cells, monocytes/macrophages, hepatocytes, and endothelial cells leading to the release of immune mediators during SD [ 31 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Scenario of Dengue in Brazil

Fares

Souza

Áñez

et al. 2015

BioMed Research International

122

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Dengue is the most important reemerging mosquito-borne viral disease worldwide. It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes. Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Scenario of Dengue in Brazil

Fares

Souza

Áñez

et al. 2015

BioMed Research International

122

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“…The extent of molecular evolution within DEN-1, DEN-2, DEN-3, and DEN-4 genotypes has been described previously [Blok et al, 1989[Blok et al, , 1991Lewis et al, 1993;Zulkarnain et al, 1994]. Based on the nucleotide (nt) sequence of the E and E/NS1 gene region, DEN-1 viruses have been classified into three to five genotypes [Rico-Hesse, 1990;Chungue et al, 1995], DEN-2 viruses into five genotypes [Rico-Hesse et al, 1997], DEN-3 viruses into four genotypes [Lanciotti et al, 1994], and DEN-4 viruses into two genotypes [Chungue et al, 1995].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiological study of dengue virus type 1 in Taiwan

Hwang

Chu

Tung

et al. 2003

Journal of Medical Virology

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Taiwan has experienced several major outbreaks of dengue (DEN) virus since 1981. The predominant virus type involved has been dengue virus type one (DEN-1), which first appeared in 1987. To understand the molecular epidemiology of this virus, 15 strains of DEN-1 isolated during 1987-1991 and 1994-1995, including 11 epidemic strains, two sporadic strains, and two imported strains have been studied. Fragments of 490 nucleotides (nt) from the E/NS1 junction were amplified by reverse transcription-polymerase chain reaction and the nt sequences were determined. Of the 490 nt of the E/NS1 junction, 240 nt (nt 2282-2521) were aligned and compared. Nucleotide substitutions were found at 54 positions among 15 isolates. Most nt changes were synonymous substitutions, and only three amino acid changes were found. A total of 61 strains isolated worldwide were analyzed by the Neighbor-joining method, and separated phylogenetically into three distinct genotypes, I-III. Genotype I comprised isolates from Japan and Hawaii collected in the 1940s. Genotype II included most strains isolated from Asia in 1977-1995. Genotype III consisted of isolates from three continents in 1964-1995: Asia, the Americas, and Africa. Genotype III was divided further into two subgenotypes, IIIA and IIIB. Most recent isolates from Taiwan, except for the sporadic strain isolated in 1995, were similar genetically and have been classified as Genotype II.

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“…The prototype DENV-1 serotype is known as the Mochizuki strain, which later diverged to genotypes I, II, III, IV, and V in different geographic regions. 55 In animal studies, DENV-1 has been demonstrated to have an extended duration of viremia compared with other serotypes. DENV-1 virulence has also been described elsewhere.…”

Section: Discussionmentioning

confidence: 99%

A Cluster of Dengue Cases in Travelers: A Clinical Series From Thailand

Imad¹,

Phadungsombat²,

Nakayama³

et al. 2021

Preprint

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Dengue is an overlooked tropical disease for which billions of people are at risk. The disease, caused by a Flavivirus with four distinct serotypes, is transmitted primarily by urbanized Aedes mosquito species. The infection leads to a spectrum of clinical manifestations, with the majority being asymptomatic. Primary dengue and, to a greater extent, subsequent infection, mainly secondary dengue infection, are associated with increased severity. Increased global travel and recreational tourism expose naïve individuals to dengue, the most common arboviral infections in travelers. We describe a cluster of possible primary acute dengue infections in a group of 12 individuals who presented to Bangkok Hospital for Tropical Diseases in 2017. Infection was confirmed by dengue NS1 antigen and multiplex real-time RT-PCR. Nine individuals required hospitalization, and four developed dengue warning signs. The mean arterial pressure was significantly lower in the group with dengue warning signs. The period from the day of arrival in Thailand and the first day of symptoms was significantly shorter in adolescents with warning signs. Leukocytes, neutrophils, and platelets declined significantly at defervescence and were negatively correlated with day of illness. Six clinical isolates were identified as dengue serotype-1, with identical sequences suggesting that these patients were infected with the same virus.

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Molecular Comparison of Dengue Type 1 Mochizuki Strain Virus and Other Selected Viruses Concerning Nucleotide and Amino Acid Sequences of Genomic RNA: A Consideration of Viral Epidemiology and Variation

Cited by 9 publications

References 24 publications

Epidemiological Scenario of Dengue in Brazil

Epidemiological Scenario of Dengue in Brazil

Molecular epidemiological study of dengue virus type 1 in Taiwan

A Cluster of Dengue Cases in Travelers: A Clinical Series From Thailand

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