Molecular Cloning of PTC, a New Oncogene Found Activated in Human Thyroid Papillary Carcinomas and Their Lymph Node Metastases <sup>a</sup>

Grieco, Michèle; Santoro, Massimo; Berlingieri, Maria Teresa; Donghi, R.; Porta, Giuseppe Della; Vecchio, Giancarlo

doi:10.1111/j.1749-6632.1988.tb22370.x

Cited by 20 publications

(12 citation statements)

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“…The RET protooncogene is rearranged in a variable proportion of sporadic PTC tumours (13)(14)(15). In addition, RET mutations have been implicated in the development of familial multiple endocrine neoplasia (MEN) 2A of which medullary carcinoma of the thyroid (MTC) is the main manifestation (28) although MTC and PTC may be present (29).…”

Section: Discussionmentioning

confidence: 99%

“…These include: the MNG1 and TCO1 loci, two genes recently mapped to chromosomes 14q31 and 19p13.2 respectively, in familial non-medullary thyroid carcinoma families (11,12), genes associated with the sporadic form of the cancer, the RET (13)(14)(15), TRK (16,17) and MET (18) tyrosine kinases, genes associated with familial syndromes with associated PTC, the APC and PTEN tumour suppressors associated with familial adenomatous polyposis coli (19,20) and Cowden (21) syndrome respectively and finally genes such as the TSHR which due to its function could be implicated in thyroid cancer, in addition to its proven involvement in other thyroid pathologies (22,23).…”

Section: Introductionmentioning

confidence: 99%

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At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

Mckay¹,

Williamson

Lesueur

et al. 1999

European Journal of Endocrinology

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Recent studies have mapped two susceptibility loci which appear to account for familial multinodular goitre (MNG1) and a variant of familial papillary thyroid cancer (PTC), with associated multinodular goitre (TCO). A Tasmanian family (Tas1) has been identified with an autosomal dominant form of PTC.This study has examined the MNG1 and TCO loci to determine if they are similarly predisposing the Tas1 family to PTC. Linkage analysis using identical microsatellite markers described in the two previous studies was used to determine the significance of these loci in the Tasmanian family. The resultant LOD scores were sufficiently negative using multipoint parametric analysis to exclude these two loci from involvement in the Tasmanian family.In addition, six candidate genes, RET, TRK, MET, TSHR, APC and PTEN were also excluded as susceptibility genes in Tas1 by using microsatellites that are positioned in or in close proximity to these genes. These results suggest that there are at least three susceptibility genes that predispose families to familial PTC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

Mckay¹,

Williamson

Lesueur

et al. 1999

European Journal of Endocrinology

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“…There is a list of candidate genes with implicated roles in thyroid tumor formation, including ret/ptc, trk, and ras oncogenes, activating mutations of BRAF, the tumor suppressor gene p53, Pax8/peroxisome proliferatoractivated receptor ␦ rearrangement, and candidate tumor suppressor genes on chromosomes 11q13, 3p, and 7q (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). However, there remain thyroid carcinomas for which none of the currently identified genes or mutations can be identified.…”

Section: Introductionmentioning

confidence: 99%

TC-1 Is a Novel Tumorigenic and Natively Disordered Protein Associated with Thyroid Cancer

Sunde

McGrath²,

Young³

et al. 2004

Cancer Research

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A novel gene, thyroid cancer 1 (TC-1), was found recently to be overexpressed in thyroid cancer. TC-1 shows no homology to any of the known thyroid cancer-associated genes. We have produced stable transformants of normal thyroid cells that express the TC-1 gene, and these cells show increased proliferation rates and anchorage-independent growth in soft agar. Apoptosis rates also are decreased in the transformed cells. We also have expressed recombinant TC-1 protein and have undertaken a structural and functional characterization of the protein. The protein is monomeric and predominantly unstructured under conditions of physiologic salt and pH. This places it in the category of natively disordered proteins, a rapidly expanding group of proteins, many members of which play critical roles in cell regulation processes. We show that the protein can be phosphorylated by cyclic AMP-dependent protein kinase and protein kinase C, and the activity of both of these kinases is up-regulated when cells are stably transfected with TC-1. These results suggest that overexpression of TC-1 may be important in thyroid carcinogenesis.

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“…The sequence of the breakpoint 190 was as that previously described. [172][173][174] However, we noted a silent GTT to GTC change in the third position of codon 99, which may be due to a polymorphism or a point mutation. Of greater interest is that this tumor also harbored a mutation in the tumor suppressor gene p53 (Ala 161 →Thr).…”

Section: Ret/ptc Rearrangement In Saudi Patients With Thyroid Tumorsmentioning

confidence: 69%

“…Ptc/Ret Rearrangement PTC/RET (previously PTC for papillary thyroid carcinoma) oncogene [172][173][174][175][176] results from the fusion of the tyrosine kinase domain of the proto-oncogene ret with unknown sequence as a result of chromosomal rearrangement. The activation of RET/PTC resulted from paracentric inversion of the long arm of chromosome 10, inv (10) (q 11.2 q21) with breakpoint involving the regions where RET and D10S170 are located 177 ( Figure 2).…”

Section: Ptc/ret Oncogenementioning

confidence: 99%

Towards Understanding the Molecular Basis of Thyroid Cancer

Farid

1995

Annals of Saudi Medicine

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Molecular Cloning of PTC, a New Oncogene Found Activated in Human Thyroid Papillary Carcinomas and Their Lymph Node Metastases ^a

Cited by 20 publications

References 1 publication

At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

TC-1 Is a Novel Tumorigenic and Natively Disordered Protein Associated with Thyroid Cancer

Towards Understanding the Molecular Basis of Thyroid Cancer

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Molecular Cloning of PTC, a New Oncogene Found Activated in Human Thyroid Papillary Carcinomas and Their Lymph Node Metastases a

Cited by 20 publications

References 1 publication

At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

TC-1 Is a Novel Tumorigenic and Natively Disordered Protein Associated with Thyroid Cancer

Towards Understanding the Molecular Basis of Thyroid Cancer

Contact Info

Product

Resources

About

Molecular Cloning of PTC, a New Oncogene Found Activated in Human Thyroid Papillary Carcinomas and Their Lymph Node Metastases ^a