Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up‐regulated during postnatal mouse cerebral development

Dan, Ippeita; Watanabe, Nobuatsu; Kobayashi, Takashi; Suzuki, Kaoru; Fukagaya, Yukiko; Kajikawa, Eriko; Kimura, Wataru; Nakashima, Takashi; Matsumoto, Kunihiro; Ninomiya‐Tsuji, Jun; Kusumi, Akihiro

doi:10.1016/s0014-5793(00)01247-3

Cited by 68 publications

(58 citation statements)

References 22 publications

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“…The vertebrate homologue of Misshapen is a GCK (Germinal Center Kinase) termed Mink-1 (for Misshapen/Nik-related Kinase-1). Mutational analysis of Mink-1 in vertebrates has not been reported; however, mink-1 gene expression is upregulated in cortical progenitors when cell migration initiates during development (Dan et al, 2000). In addition, two other kinases, Fak (Focal Adhesion Kinase) and Cdk5 (Cyclin-Dependent Kinase-5), have been shown to work together to regulate nucleokinesis.…”

Section: Kinases In Nuclear Migrationmentioning

confidence: 99%

Nuclear migration during retinal development

2008

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In this review we focus on the mechanisms, regulation, and cellular consequences of nuclear migration in the developing retina. In the nervous system, nuclear migration is prominent during both proliferative and post-mitotic phases of development. Interkinetic nuclear migration is the process where the nucleus oscillates from the apical to basal surfaces in proliferative neuroepithelia. Proliferative nuclear movement occurs in step with the cell cycle, with M-phase being confined to the apical surface and G1-, S-, and G2-phases occurring at more basal locations. Later, following cell cycle exit, some neuron precursors migrate by nuclear translocation. In this mode of cellular migration, nuclear movement is the driving force for motility. Following discussion of the key components and important regulators for each of these processes, we present an emerging model where interkinetic nuclear migration functions to distinguish cell fates among retinal neuroepithelia. Keywordsinterkinetic nuclear migration; nuclear translocation; nucleokinesis; neurogenesis; dynein; cell cycle; cell behavior OverviewNeuronal development is regulated by a complex array of intrinsic and extrinsic signals that act on progenitor neuroepithelial cells to ensure the correct cell type is generated in the right numbers and at the appropriate time of development (Donovan et al., 2005;Cayouette et al., 2006). In addition, multiple signaling cues are integrated in post-mitotic neuronal precursors to facilitate directed cell migration and correct laminar positioning (Malicki et al., 2004). This spatial and temporal regulation of neuronal cell-type fate commitment and histogenesis is dependent on the regulation of the mitotic cell cycle, and in particular at the level of cell cycle exit (Ohnuma and Harris, 2003). Recent data suggest that nuclear migration is a critical process for several aspects of neuronal development, including that of the neural retina. The focus of this review is on interkinetic nuclear migration and nuclear translocation during retinogenesis, although much of what we know is from observations in other regions of the developing nervous system. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript Interkinetic nuclear migrationInterkinetic nuclear migration is the proliferative cell behavior where the nuclei of neuroepithelial cells migrate in an apical-basal manner and in phase with the cell cycle (Frade 2002). Neuroepithelial cell divisions are confined to apical locations while S-phase occu...

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Section: Kinases In Nuclear Migrationmentioning

confidence: 99%

Nuclear migration during retinal development

2008

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“…The kinase moieties of the class III myosins are members of the germinal center kinase subfamily of the Ste20 group kinases (Sells and Chernoff, 1997;Dan et al, 2000). These kinase/myosin chimeras now constitute their own germinal center kinase subfamily VII (Dan et al, 2000).…”

Section: Class III Myosinsmentioning

confidence: 99%

“…These kinase/myosin chimeras now constitute their own germinal center kinase subfamily VII (Dan et al, 2000). The kinase domains of Myo3A and 3B most closely resemble Misshapen/NIKs-related kinase (MINK), which has been shown to activate the cJun N-terminal kinase and p38 pathways (Dan et al, 2000).…”

Section: Class III Myosinsmentioning

confidence: 99%

Myo3A, One of Two Class III Myosin Genes Expressed in Vertebrate Retina, Is Localized to the Calycal Processes of Rod and Cone Photoreceptors and Is Expressed in the Sacculus

Dosé

Hillman

Wong

et al. 2003

MBoC

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The striped bass has two retina-expressed class III myosin genes, each composed of a kinase, motor, and tail domain. We report the cloning, sequence analysis, and expression patterns of the long (Myo3A) and short (Myo3B) class III myosins, as well as cellular localization and biochemical characterization of the long isoform, Myo3A. Myo3A (209 kDa) is expressed in the retina, brain, testis, and sacculus, and Myo3B (155 kDa) is expressed in the retina, intestine, and testis. The tails of these two isoforms contain two highly conserved domains, 3THDI and 3THDII. Whereas Myo3B has three IQ motifs, Myo3A has nine IQ motifs, four in its neck and five in its tail domain. Myo3A localizes to actin filament bundles of photoreceptors and is concentrated in the calycal processes. An anti-Myo3A antibody decorates the actin cytoskeleton of rod inner/outer segments, and this labeling is reduced by the presence of ATP. The ATP-sensitive actin association is a feature characteristic of myosin motors. The numerous IQ motifs may play a structural or signaling role in the Myo3A, and its localization to calycal processes indicates that this myosin mediates a local function at this site in vertebrate photoreceptors. INTRODUCTIONThe asymmetrical shapes of the rods and cones of the vertebrate retina are specialized to mediate photon detection and signal transmission. At the distal ends are the outer segments, which are composed of stacks of photopigmentbearing membranous disks surrounded by the plasma membrane. Progressively proximal to the outer segment are the mitochondrion-packed ellipsoid, the endoplasmic reticulum-and Golgi-rich myoid, the perinuclear region, the axon, and the synapse. The outer segment is connected to the rest of the cell by the narrow connecting cilium, through which metabolic fuels and newly synthesized proteins are transported. Although they maintain highly specialized shapes, photoreceptors are not static. Elaborately choreographed morphogenetic movements establish the specialized shapes of photoreceptors during development. Once formed, photoreceptors undergo outer segment turnover throughout life. This turnover is mediated by the daily addition of new disks to the base of the outer segment and the shedding of effete disks from the tip (Young, 1976). Disk addition requires transport of newly synthesized materials from the perinuclear and myoid regions to and through the connecting cilium. More dramatic photoreceptor motility occurs during retinomotor movements of lower vertebrates; light onset induces cone myoids to contract and rod myoids to elongate, whereas dark onset induces opposite movements (Burnside, 1978).Several observations suggest that the actin cytoskeleton plays an important role in photoreceptor motile processes. Photoreceptors are richly endowed with actin filaments deployed in distinct populations and likely to reflect specialized functional roles. Filamentous actin is concentrated in the distal connecting cilium of the outer segment (Chaitin et al., 1984;Wolfrum and Schmitt, 2000) and throu...

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“…Furthermore, many of these same kinases are involved in numerous variable upstream pathways including the transforming growth factor-b (TGF-b) pathway (Zhou et al, 1999), binding to and interacting with the Crk and the CrkL family of adaptor molecules (Oehrl et al, 1998;Ling et al, 1999), and activation of integrins through Eph receptors (Becker et al, 2000). Other potential physiological roles recently reported include involvement in lymphocyte aggregation through the regulation of leukocyte-function-associated antigen (LFA)-1-mediated clustering (Endo et al, 2000), cerebral development in mice (Dan et al, 2000), and in T-cell receptor signaling (Ling et al, 2001). These physiological interactions and functions exemplify the diversity of signaling pathways that these kinases may be involved in.…”

Section: Introductionmentioning

confidence: 99%