Molecular cloning, genomic organization, chromosome mapping, tissues expression pattern and identification of a novel splicing variant of porcine CIDEb gene

Lǐ, Yànhuá; Li, Aihua; Zhou, Yang

doi:10.1016/j.bbrc.2016.05.079

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…A previous study reported that mouse CIDE-B mRNA is expressed significantly in the liver, kidneys, small intestine, colon, and WAT (Li et al, 2007;Wu et al, 2008). Another study reported that porcine CIDE-B is expressed in the WAT, liver, and small intestine (Li et al, 2016), and was expressed at significantly higher levels in the WAT of lean pigs than that in obese pigs (Li et al, 2016). It was predicted that CIDE-B would be expressed in the adipose tissue and might play a crucial role in regulating the fat content of pork.…”

Section: Cide-b Mrna Expression During Adipogenesismentioning

confidence: 96%

“…Furthermore, the important role of apoptosis induced by CIDE-B is mediated by regulation of lipid metabolism and storage (Xu et al, 2012). The porcine CIDE-B is located on chromosome 7 c.841 and is associated with fat deposition and metabolism (Li et al, 2016). In addition, CIDE-B can affect the variations in protein and shrinkage regulation of muscle during post-mortem meat conditioning (Rybarczyk et al, 2015).…”

Section: Cide-b Mrna Expression During Adipogenesismentioning

confidence: 99%

“…CIDE-B is highly expressed in the liver, kidney, small intestine, colon, and white adipose tissue (WAT), but not in the brown adipose tissue and skeletal muscle, of mice (Li et al, 2007;Wu et al, 2008). In addition, CIDE-B mRNA expression is upregulated in the WAT, liver, lung, small intestine, lymphatic tissue, and brain of pigs (Li et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Effects of cell death-inducing DFF45-like effector B on meat quality traits in Berkshire pigs

Yu¹,

Kwon²,

Hwang³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Cell death-inducing DFF45-like effector (CIDE) B is a member of the CIDE family of apoptosis-inducing factors. In the present study, we detected a single nucleotide polymorphism (SNP), c.414G>A, which corresponds to the synonymous SNP 414Arg, in CIDE-B in the Berkshire pigs. We also analyzed the relationships between the CIDE-B SNP and various meat quality traits. The SNP was significantly associated with post-mortem pH 24h , water-holding capacity (WHC), fat content, protein content, drip loss, post-mortem temperature at 12 h (T12) and 24 h (T24) in a co-dominant model (P < 0.05). A significant association was detected between the SNP and post-mortem pH 24h , fat content, protein content, drip loss, shear force, and T24 in gilts; and color parameter b*, WHC, and T24 in barrows (P < 0.05). The SNP was significantly correlated with the fat content, and CIDE-B mRNA expression was significantly upregulated during the early stage of adipogenesis, suggesting that CIDE-B may contribute towards initiation of adipogenesis (P < 0.05). Furthermore, CIDE-B mRNA was strongly expressed in the liver, kidney, large intestine, and small intestine, and weakly expressed in the stomach, lung, spleen, and white adipose tissue. These results indicate that the CIDE-B SNP is closely associated with meat quality traits and may be a useful DNA marker for improving pork quality.

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Section: Cide-b Mrna Expression During Adipogenesismentioning

confidence: 96%

Section: Cide-b Mrna Expression During Adipogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of cell death-inducing DFF45-like effector B on meat quality traits in Berkshire pigs

Yu¹,

Kwon²,

Hwang³

et al. 2017

Genet. Mol. Res.

View full text Add to dashboard Cite

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Characterization and expression analysis of seven lipid metabolism-related genes in yellow catfish Pelteobagrus fulvidraco fed high fat and bile acid diet

Li,

Zheng,

Luo

et al. 2024

Gene

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Unveiling the Multifaceted Role of CIDEB: From Apoptosis to Lipid Metabolism and Liver Health

Wutsdorff,

Mougnekabol,

Tang

et al. 2024

Livers

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Cell-death-inducing DNA fragmentation factor-alpha (DFFA)-like effector b (CIDEB) was first identified as an apoptosis-inducing protein. Further research revealed a pivotal role in lipid metabolism, regulating very-low-density lipoprotein (VLDL), lipid droplets (LD), sterol response element-binding protein (SREBP), and chylomicrons. Recent studies have uncovered that rare germline variants in CIDEB protect against liver diseases, including MAFLD, cirrhosis, and viral hepatitis. Furthermore, CIDEB influences steps of the hepatitis C virus (HCV) replication cycle. This review summarizes the current knowledge about CIDEB’s roles in apoptosis, lipid metabolism, and viral hepatitis, and highlights its critical role in liver diseases.

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Molecular cloning, genomic organization, chromosome mapping, tissues expression pattern and identification of a novel splicing variant of porcine CIDEb gene

Cited by 3 publications

References 20 publications

Effects of cell death-inducing DFF45-like effector B on meat quality traits in Berkshire pigs

Effects of cell death-inducing DFF45-like effector B on meat quality traits in Berkshire pigs

Characterization and expression analysis of seven lipid metabolism-related genes in yellow catfish Pelteobagrus fulvidraco fed high fat and bile acid diet

Unveiling the Multifaceted Role of CIDEB: From Apoptosis to Lipid Metabolism and Liver Health

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