Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene

Shimizu, Ken; Chen, Wei; Ashique, Amir M.; Moroi, Ryoji; Li, Yi Ping

doi:10.1016/s0378-1119(03)00406-2

Cited by 43 publications

(53 citation statements)

References 36 publications

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“…The high level of conservation implicates that CNBP may play an essential biological roles across different species throughout evolution (Shimizua et al, 2003). Recently, Armas et al (2004) have observed the highest level of CNBP transcripts in adult zebrafish ovary, but little is known about its functional significance during oogenesis.…”

Section: Differential Expression and Developmental Behaviour Of Cagcnmentioning

confidence: 99%

“…In Bufo arenarum, Northern blot analysis revealed two transcripts with different expressions of pattern behaviour, and subcellular localization of CNBP was reported during oogenesis and early embryogenesis (Armas et al, 2001). During mouse embryogenesis, CNBP plays important roles in cell proliferation and tissue patterning during anterior -posterior axis, craniofacial and limb development by targeting c-Myc (Shimizua et al, 2003), and it is essential for the forebrain induction and specification . In fish, the highest level of CNBP transcripts has been observed in adult zebrafish ovary (Armas et al, 2004), but its distribution and functional roles during oogenesis is unclear up to the present.…”

Section: Introductionmentioning

confidence: 99%

“…During embryogenesis, the CNBP expression patterns have been analyzed in Xenopus leavis (Flink et al, 1998), Bufo arenarum (Armas et al, 2001), mouse Shimizua et al, 2003), and Danio rerio (Armas et al, 2004). In Xenopus leavis, CNBP mRNA could be detected in the unfertilized eggs and in the embryonic cells derived from early ectoderm, endoderm, and mesoderm (Flink et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Expression pattern and developmental behaviour of cellular nucleic acid-binding protein (CNBP) during folliculogenesis and oogenesis in fish

Liu

Gui

2005

Gene

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Section: Differential Expression and Developmental Behaviour Of Cagcnmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression pattern and developmental behaviour of cellular nucleic acid-binding protein (CNBP) during folliculogenesis and oogenesis in fish

Liu

Gui

2005

Gene

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“…During embryogenesis, the CNBP expression patterns have been analyzed in Bufo arenarum, Xenopus leavis, Danio rerio, mouse and chick [3,8,9,[11][12][13]. During early embryogenesis, CNBP mRNA could be detected in the The nucleotide sequence data reported in this paper have been submitted to the GenBank under accession number: CagCNBP (AY773183).…”

Section: Introductionmentioning

confidence: 99%

“…During early embryogenesis, CNBP mRNA could be detected in the The nucleotide sequence data reported in this paper have been submitted to the GenBank under accession number: CagCNBP (AY773183). unfertilized eggs and in the all embryonic cells in frog, zebrafish, cattle, chick and mouse [3,8,9,[11][12][13]. In mouse, during organogenesis, CNBP expresses predominantly in forebrain and midbrain, and plays important roles in cell proliferation and tissue patterning [12], and it is essential for the forebrain induction and specification [11].…”

Section: Introductionmentioning

confidence: 99%

Expression pattern of cellular nucleic acid-binding protein (CNBP) during embryogenesis and spermatogenesis of gibel carp

2008

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By differential screening, we cloned the Cag-CNBP, demonstrated its predominant expression in ovary and testis, and reported its development behavior during folliculogenesis and oogenesis by immunofluorescence localization (Liu and Gui, Gene 365:181-192, 2005), but its developmental behavior during spermatogenesis and its transcript distribution during embryogenesis are not revealed. In the present study, by in situ hybridization, we analyze CagCNBP expression pattern during gibel carp embryogenesis. The CagCNBP transcripts ubiquitously distributed in all embryonic cells in early developmental stage embryos, and peak in midbrain, hindbrain and somites of gibel carp larva during organogenesis. By antibody detection, we reveal CagCNBP protein distribution change during spermatogenesis. The cell-specific distribution of CagCNBP is revealed by immunofluorescence staining, and predominant CagCNBP expression in testis somatic cells and spermatogonia is demonstrated in this paper. For the first time, the CNBP distribution during spermatogenesis in vertebrate has been revealed.

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Myotonic Dystrophy and Developmental Regulation of RNA Processing

Thomas

Oliveira

Sznajder

et al. 2018

Comprehensive Physiology

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Myotonic dystrophy (DM) is a multisystemic disorder caused by microsatellite expansion mutations in two unrelated genes leading to similar, yet distinct, diseases. DM disease presentation is highly variable and distinguished by differences in age-of-onset and symptom severity. In the most severe form, DM presents with congenital onset and profound developmental defects. At the molecular level, DM pathogenesis is characterized by a toxic RNA gain-of-function mechanism that involves the transcription of noncoding microsatellite expansions. These mutant RNAs disrupt key cellular pathways, including RNA processing, localization, and translation. In DM, these toxic RNA effects are predominantly mediated through the modulation of the muscleblind-like and CUGBP and ETR-3-like factor families of RNA binding proteins (RBPs). Dysfunction of these RBPs results in widespread RNA processing defects culminating in the expression of developmentally inappropriate protein isoforms in adult tissues. The tissue that is the focus of this review, skeletal muscle, is particularly sensitive to mutant RNA-responsive perturbations, as patients display a variety of developmental, structural, and functional defects in muscle. Here, we provide a comprehensive overview of DM1 and DM2 clinical presentation and pathology as well as the underlying cellular and molecular defects associated with DM disease onset and progression. Additionally, fundamental aspects of skeletal muscle development altered in DM are highlighted together with ongoing and potential therapeutic avenues to treat this muscular dystrophy. © 2018 American Physiological Society. Compr Physiol 8:509-553, 2018.

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Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene

Cited by 43 publications

References 36 publications

Expression pattern and developmental behaviour of cellular nucleic acid-binding protein (CNBP) during folliculogenesis and oogenesis in fish

Expression pattern and developmental behaviour of cellular nucleic acid-binding protein (CNBP) during folliculogenesis and oogenesis in fish

Expression pattern of cellular nucleic acid-binding protein (CNBP) during embryogenesis and spermatogenesis of gibel carp

Myotonic Dystrophy and Developmental Regulation of RNA Processing

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