Molecular cloning and polymorphism of the porcine H2AFZ gene

Zhang, Y. H.; Mei, Shuqi; Peng, Xianwen; Zuo, B.; Lei, Minggang; Xiong, Yan; Li, F. E.

doi:10.1017/s1751731109004170

Cited by 4 publications

(2 citation statements)

References 15 publications

(20 reference statements)

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“…Another candidate gene under putative selection is H2AFZ ( histone H2A.Z ), located within SCR5. H2AFZ is required for early mammalian development [ 43 ], and in pig, it is related to litter size [ 44 , 45 ]. Sasi Ardi ewes are characterized by low fertility and small litter size, due, in part, to the harsh environment in which the breed is raised [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Genomic selection signatures in sheep from the Western Pyrenees

et al. 2018

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BackgroundThe current large spectrum of sheep phenotypic diversity results from the combined product of sheep selection for different production traits such as wool, milk and meat, and its natural adaptation to new environments. In this study, we scanned the genome of 25 Sasi Ardi and 75 Latxa sheep from the Western Pyrenees for three types of regions under selection: (1) regions underlying local adaptation of Sasi Ardi semi-feral sheep, (2) regions related to a long traditional dairy selection pressure in Latxa sheep, and (3) regions experiencing the specific effect of the modern genetic improvement program established for the Latxa breed during the last three decades.ResultsThirty-two selected candidate regions including 147 annotated genes were detected by using three statistical parameters: pooled heterozygosity H, Tajima’s D, and Wright’s fixation index Fst. For Sasi Ardi sheep, chromosomes Ovis aries (OAR)4, 6, and 22 showed the strongest signals and harbored several candidate genes related to energy metabolism and morphology (BBS9, ELOVL3 and LDB1), immunity (NFKB2), and reproduction (H2AFZ). The major genomic difference between Sasi Ardi and Latxa sheep was on OAR6, which is known to affect milk production, with highly selected regions around the ABCG2, SPP1, LAP3, NCAPG, LCORL, and MEPE genes in Latxa sheep. The effect of the modern genetic improvement program on Latxa sheep was also evident on OAR15, on which several olfactory genes are located. We also detected several genes involved in reproduction such as ESR1 and ZNF366 that were affected by this selection program.ConclusionsNatural and artificial selection have shaped the genome of both Sasi Ardi and Latxa sheep. Our results suggest that Sasi Ardi traits related to energy metabolism, morphological, reproductive, and immunological features have been under positive selection to adapt this semi-feral sheep to its particular environment. The highly selected Latxa sheep for dairy production showed clear signatures of selection in genomic regions related to milk production. Furthermore, our data indicate that the selection criteria applied in the modern genetic improvement program affect immunity and reproduction traits.Electronic supplementary materialThe online version of this article (10.1186/s12711-018-0378-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Genomic selection signatures in sheep from the Western Pyrenees

et al. 2018

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“…There was a 4 bp deletion/insertion in intron 2 detected in H2AFZ histone family gene and a PCR-Bsu151-RFLP was established to detect this variation in Large White and Meishan pigs. In 4th dam line of Chinese lean-type new lines pigs, the females had less piglets born alive with AA then those with AB or BB genotype (Zhang et al, 2009). Leptin (Lep) was originally identifield following physical mapping of this gene in case of obese in mice (Zhang et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Association and polymorphism study of seven candidate genes with reproductive traits in three pig breeds in Hungary.

et al. 2016

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Seven genes (BF, EGF, ESR, FSHB, H2AFZ, LEP and PRLP) were studied as candidate gene influencing eleven reproduction traits (interval between litters (IBL), percent of litter (PL), number of litters (NL), number of piglets born dead (NBD), number of piglet born alive (NBA), total number born (TNB), mean of born alive (MBA), mean of born dead (MBD), mean of born total (MBT), mean of piglets at 21 days of age (M21D) and growth rate (GR) in three pig breeds (Hungarian Large White (HLW), Duroc and Pietrain) by PCR-RFLP. Based on the observed vs. expected genotypes frequencies populations across loci were in Hardy-Weinberg equilibrium (P>0.05). In case HLW breed ESR and FSHβ genes were in disequilibrium. Association study suggested that only EGF gene showed significant influence on the trait NBA and TNB. The AA genotype are preferable for sows, associated with higher NBA and TNB. The longest IBL, and the highest NL is associated with AB and AA genotype of EGF gene. IBL is significantly shorter in case of pigs with AB and AA alleles than BB alleles of PRLP genes. Selection for these SNPs could improve the reproductivity in the studied breeds.

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H2AFZ, RNF4 and NR4A1 loci are associated with boar semen quality by population association studies

Zhao

Song

et al. 2018

Animal Biotechnology

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Molecular cloning and polymorphism of the porcine H2AFZ gene

Cited by 4 publications

References 15 publications

Genomic selection signatures in sheep from the Western Pyrenees

Genomic selection signatures in sheep from the Western Pyrenees

Association and polymorphism study of seven candidate genes with reproductive traits in three pig breeds in Hungary.

H2AFZ, RNF4 and NR4A1 loci are associated with boar semen quality by population association studies

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