“…10,11 A series of allergenic polcalcins have been reported in the literature, namely Aln g 4 from alder (Alnus glutinosa), 12 Ole e 3 from olive (Olea europaea), 13,14 Syr v 3 from lilac (Syringa vulgaris; Ledesma et al, unpublished), Bra n 1 or BPC1 and Bra n 2 from oilseed rape (Brassica napus) as well as Bra r 1 and Bra r 2 from turnip rape (Brassica rapa), 15 -18 Phl p 7 from timothy grass (Phleum pratense), 19 and Cyn d 7 from Bermuda grass (Cynodon dactylon). 20,21 Aln g 4, Syr v 3, Bra n 1 or BPC1, Bra n 2, Bra r 1, Bra r 2 and Phl p 7 as well as the polcalcin APC1 from mouse-ear cress (Arabidopsis thaliana), 18 however, have not been included in the official allergen list of the International Union of Immunological Societies (IUIS) yet and the allergen designations Bra n 1 and Bra r 2 even conflict with two unrelated allergens. 22 These polcalcins share more than 65% sequence identity with Bet v 4 ( Figure 1) and due to their widespread distribution over the plant kingdom and their high IgE cross-reactivity 10 -13,17,19 -21 they might constitute so-called panallergens.…”