Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily

Hasegawa, Hitoshi; Watanabe, Hiroshi; Nomura, Takanobu; Utsunomiya, Y; Yanagisawa, Kohsuke; Fujita, Shigeru

doi:10.1016/s0167-4781(97)00095-x

Cited by 17 publications

(21 citation statements)

References 34 publications

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“…Within the TM4SF motif, the amino acid sequence identity between clone 5R3 and mouse and human CD151 was 100% and 95%, respectively (Figure 3). Of note, the 5' and 3' UTR of clone 5R3 were highly similar to the mouse CD151 cDNA (Hasegawa et al 1997), but were different from those of human CD151 (Fitter et al 1995). On the basis of sequence analysis, it was concluded that this clone is a true orthologue of the human/mouse CD151, thus designated as rCD151.…”

Section: Characterization Of Clone 5r3mentioning

confidence: 99%

“…The presence of CD151 mRNA in rat brain is unlikely due only to expression in the vascular endothelial compartment because the transcripts are also present at high levels in cultured cortical neurons. Moreover, there is also evidence of CD151 expression in the developing rat brain, PC12 cells (L. Ashman, personal communication), and human neuronal NT2N cells (Stipp and Hemler 2000), further supporting the idea that CD151 is also neuronally expressed.The presence of three mRNA species in various rat tissues is peculiar, since human and mouse CD151 have been shown to express only one single transcript (Fitter et al 1995;Hasegawa et al 1997). It is likely that we isolated the cDNA corresponding to the 1.6 kb form of rCD151.…”

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confidence: 99%

“…Potential sites for phosphorylation by protein kinase C are present on predicted intracellular domain and carboxyl terminus (residues 82 and 247). There is also one possible site for phosphorylation by protein kinase A on the amino terminus (residue 10).Comparison of the cDNA and predicted amino acid sequences with those in the GenBank database demonstrated sequence similarity between clone 5R3 and members of the TM4SF, particularly with a 96% amino acid homology with mouse CD151 (Hasegawa et al 1997) and 92% with human CD151 (Fitter et al 1995). Within the TM4SF motif, the amino acid sequence identity between clone 5R3 and mouse and human CD151 was 100% and 95%, respectively (Figure 3).…”

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confidence: 99%

“…5 Regulation of CD151 mRNA Expression by Mood Stabilizers 733 molecular changes leading to therapeutic response to these mood-stabilizing drugs. Although initially identified as a platelet/leukocyte surface glycoprotein, CD151 is expressed in a wide variety of tissues and cell types including megakaryoctes, endothelial cells, and myocytes (Fitter et al 1995(Fitter et al , 1998Hasegawa et al 1997). We present here the first observations on the regional distribution of CD151 transcripts in rat brain, which is in marked contrast to that reported in earlier studies which showed very low level of expression in mouse and human brain (Sincock et al 1997;Hasegawa et al 1997).…”

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confidence: 99%

“…Although initially identified as a platelet/leukocyte surface glycoprotein, CD151 is expressed in a wide variety of tissues and cell types including megakaryoctes, endothelial cells, and myocytes (Fitter et al 1995(Fitter et al , 1998Hasegawa et al 1997). We present here the first observations on the regional distribution of CD151 transcripts in rat brain, which is in marked contrast to that reported in earlier studies which showed very low level of expression in mouse and human brain (Sincock et al 1997;Hasegawa et al 1997). The presence of CD151 mRNA in rat brain is unlikely due only to expression in the vascular endothelial compartment because the transcripts are also present at high levels in cultured cortical neurons.…”

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confidence: 99%

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Tetraspan Protein CD151 A Common Target of Mood Stabilizing Drugs?

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The latency in onset of antimanic and mood stabilizing effects of lithium suggest that long-term neuronal adaptations mediated by changes in gene expression may be important to the therapeutic action of lithium treatment. Using differential display-polymerase chain reaction, several novel, hitherto unexpected lithium-regulated genes have been isolated, all of which would not have beenAlthough lithium is widely used in the treatment of acute mania and the prophylaxis for bipolar affective disorder, the cellular and molecular mechanisms underlying its therapeutic action remain unclear. However, significant progress has been made over the past decade with cumulative evidence indicating that modulation of postreceptor signaling mechanisms in critical regions of the brain may be essential to the mood stabilizing properties of this agent (reviewed in Jope 1999;Li et al. 2000;Manji and Lenox 1999).Many signal transduction cascades are known to induce long-term cellular responses through regulation of gene transcription. Moreover, the delayed onset of therapeutic action of lithium has led to the hypothesis that regulation of gene expression may be important for its mood stabilizing effects (Jope 1999;Li et al. 2000). In line with this hypothesis, several studies have demonstrated that chronic lithium treatment alters the expression of an array of genes, including G protein ␣ -subunits, adenylyl cyclase subtypes, neuropeptides (reviewed in Jope 1999;Li et al. 2000;Manji and Lenox 1999) NO . 5 et al. 2000). The modulatory effects of lithium on gene expression have been suggested to be mediated, at least in part, through the cAMP response element binding protein (CREB) or activator protein-1 (AP-1) transcriptional factor pathway (Ozaki and Chuang 1997;Asghari et al. 1998;Yuan et al. 1998). It is thus conceivable that other genes containing the consensus sequences for these transcription factors in their promoter region may also be the potential targets of lithium. Therefore, the identification of other lithium-regulated genes is important in better understanding the spectrum of cellular and molecular mechanisms that contribute to the therapeutic and/or side effects of this drug.Using differential display-polymerase chain reaction (ddPCR), several novel lithium-regulated genes have been identified that would not otherwise have been considered using a candidate gene approach. These novel lithium-regulated targets included 2 Ј , 3 Ј -cyclic nucleotide 3 Ј -phosphodiesterase type II (Wang and Young 1996), polyomavirus enhancer-binding protein 2 ␤ (Chen et al. 1999), nitrogen permease regulator 2 (Wang et al. 1999), aldolase A (Hua et al. 2000, and diphosphoinositol polyphosphate phosphohydrolase II (Hua et al. 2001). Unexpectedly, during the course of experiments amplifying the 5 Ј end of a putative lithium-regulated ddPCR fragment, we isolated another cDNA clone, a homolog of human/mouse transmembrane-4-superfamily (TM4SF) protein, CD151. The transcript levels of CD151 were significantly decreased in the rat frontal corte...

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Section: Characterization Of Clone 5r3mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Tetraspan Protein CD151 A Common Target of Mood Stabilizing Drugs?

Hua

Green

Wong

et al. 2001

Neuropsychopharmacology

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Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1αchemokine genes

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Deep sequencing and comprehensive expression analysis identifies several molecules potentially related to human poorly differentiated hepatocellular carcinoma

et al. 2017

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Hepatocellular carcinoma (HCC) that is graded histologically as poorly differentiated has a high recurrence, metastasis and poor prognosis. We sought to determine the regulatory mechanisms of HCC tumorigenesis and to identify molecules closely related to poorly differentiated HCC. High‐throughput sequencing was used to construct microRNA (miRNA) and mRNA expression profiles for poorly differentiated HCC tissues and adjacent tissues. Network analysis was carried out to study miRNA–target interactions. Integrating the miRNA and mRNA data of HCC with four tumor grades from The Cancer Genome Atlas (TCGA) portal enabled the identification of potential closely related molecules for early diagnosis of poorly differentiated HCC. Electronic validation of RNA‐seq data and survival analysis was also performed. In total, 1051 differentially expressed genes and 165 differentially expressed miRNAs were identified between HCC tumor and paired non‐tumorous tissue. Based on 3718 miRNA–target interactions, we established an miRNA–target interaction network; the target genes were mainly involved in bile acid biosynthesis and bile secretion. Integrating expression data of HCC from TCGA indicated that two proteins, TM4SF1 and ANXA2, are convincing indicators for initial diagnosis of poorly differentiated HCC. According to the survival analysis, three proteins, ANXA2, C8orf33 and IGF2BP3, were identified as being associated with the survival time of HCC patients. Moreover, we suggest that hsa‐miR‐1180 may be an effective biomarker for poorly differentiated HCC. Three molecules, TM4SF1, ANXA2 and C8orf33, are potential biomarkers for distinguishing poorly differentiated from well‐differentiated HCC.

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Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily

Cited by 17 publications

References 34 publications

Tetraspan Protein CD151 A Common Target of Mood Stabilizing Drugs?

Tetraspan Protein CD151 A Common Target of Mood Stabilizing Drugs?

Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1αchemokine genes

Deep sequencing and comprehensive expression analysis identifies several molecules potentially related to human poorly differentiated hepatocellular carcinoma

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