Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas-mediated apoptosis

“…This report shows form, which is then proteolytically processed into a soluble that FasL is expressed in both the neoplastic and reactive cell cytokine retaining biological activity. [7][8][9][10] population from a significant proportion of lymphoma cases, There is accumulating evidence from Ipr and gld mice modand that Fas-positive malignant B cells are less sensitive to els that Fas/FasL-mediated apoptosis is a crucial regulatory Fas-mediated apoptosis than intratumoral Fas-positive reactive process which limits immune response and provides a safe-T cells. guard against emergence of auto-reactive lymphocytes.…”

Expression of the Fas-ligand gene in ejaculated sperm from adolescents with and without varicocele

“…Fas is a type I transmembrane protein that belongs to the tumor necrosis factor receptor superfamily. FasL is produced as a type II membrane protein and is a member of the tumor necrosis factor family of proteins [34,[45][46][47]. Upon binding to FasL, Fas induces apoptotic activation of intracellular caspases, effector proteins, which in turn activate the cascade of events leading to cell death [27,41,44].…”

“…Still, there are some hypotheses to justify the presence of mRNA in human sperm; the main one concluded that before the end of spermatogenesis, a translation of mRNA into proteins could occur, which is why the mRNA in human sperm can be similar to that found in the testis, indicating accurate development of spermatogenesis [33]. Recent studies in various murine and rat tissues showed that the testis is the main source of FasL mRNA in the body [34,35].…”

Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

“…Similar to other members of the TNF superfamily, FasL is synthesized as a 40-kDa type 2 transmembrane protein and acts in a juxtacrine manner (4,5). This protein is expressed by activated T lymphocytes (6) and natural killer (NK) cells (7) and by a small number of non-immune cells, mainly from immuneprivileged tissues such as testis (8), cornea (9), trophoblasts (10), and cancer cells (11,12).…”