2016
DOI: 10.1016/j.fsi.2016.05.039
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Molecular cloning and characterization of four caspases members in Apostichopus japonicus

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Cited by 27 publications
(8 citation statements)
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References 46 publications
(59 reference statements)
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“…To reveal the molecular cascade of apoptosis regulated by signaling of Cer channels, we first examined the expression of apoptotic genes after Cer injection (50) (Figure 10A). We noticed that caspase-3 and caspase-8 transcripts were both markedly upregulated by 1.35-fold ( p  < 0.05) and 2.42-fold ( p  < 0.01), respectively, compared with the control, thus indicating that these two molecules play key roles in Cer-induced apoptosis.…”
Section: Resultsmentioning
confidence: 99%
“…To reveal the molecular cascade of apoptosis regulated by signaling of Cer channels, we first examined the expression of apoptotic genes after Cer injection (50) (Figure 10A). We noticed that caspase-3 and caspase-8 transcripts were both markedly upregulated by 1.35-fold ( p  < 0.05) and 2.42-fold ( p  < 0.01), respectively, compared with the control, thus indicating that these two molecules play key roles in Cer-induced apoptosis.…”
Section: Resultsmentioning
confidence: 99%
“…Caspases, a family of cysteine proteases, play fundamental roles in apoptosis as well as immune response, resulting in the monitor of cell death (Feng et al, ; Shao et al, ). Studies have found that miR‐30e, as an important molecular switch, controls DNA damage by modulating expression of the CDK inhibitor p21 and targeting caspase‐3 (De Santis et al, ; Sohn, Peters, Piekorz, Budach, & Janicke, ).…”
Section: Discussionmentioning
confidence: 99%
“…3c), suggesting further gene duplication events in the Pacific oyster genome. The bivalve caspase-3C group are homologues to the previously identified deuterostome caspases Aj3 (echinoderm Apostichopus japonicus [41]) and Bl3 (amphioxus Branchiostoma lanceolatum [42]).…”
Section: Phylogenetic Assessment Caspases In Bivalvesmentioning
confidence: 97%